THE IMMUNE STATUS OF SCHOOL-AGE CHILDREN WITH AN ACYCLIC COURSE OF TICK-BORNE ENCEPHALITIS DEPENDING ON THE PREMORBID STATE OF THE IMMUNE SYSTEM


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Abstract

Objective. To study an immune response to changes in the bidirectional (acyclic) course of the meningeal form of tick-borne encephalitis (TBE) in school-age children depending on the presence of clinical signs of immune dysfunction in their histories. Subjects and methods. Examinations were made in 62 children aged 7-14 years at 1, 2, and 3 weeks of acute TBE. Levels 1 and 2 immunological tests were used. Results. The acyclic course of the meningeal form of the disease in school-age children has been established to be accompanied by a change in all components of the immune system. Significant deviations relate to the cellular component of immunity and show as prolonged T lymphopenia, an increase in activation markers (HLA-DR, CD50, CD54, CD38, CD71), and no significant decrease in the number of CD4+ and CD8+ lymphocytes. As viewed from the humoral and nonspecific components of immunity, a reduced number of CD20+ lymphocytes, an elevated level of all immunoglobulin classes, and an enhanced neutrophil phagocytic activity with a scarce functional reserve are typical for most children Conclusion. Children with a history of clinical signs of immune dysfunction as recurrent infection syndrome display a preponderance of activation processes of the cellular and humoral components with a later switch to a secondary immune response.

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About the authors

Eduard A. Kashuba

Tyumen State Medical University, Ministry of Health of Russia

Email: kashuba.ed@gmail.com
MD, Professor, Department of Infectious Diseases, Allergology, and Immunology with Course of Dermatovenereology and Cosmetology Tyumen, Russia

Olga A. Rychkova

Tyumen State Medical University, Ministry of Health of Russia

Email: richkovaoa@mail.ru
MD, Head, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Elena B. Khramova

Tyumen State Medical University, Ministry of Health of Russia

Email: khramova@gmail.com
MD, Head, Department of Childhood Diseases, Faculty of Pediatrics Tyumen, Russia

Lyudmila V. Khanipova

Tyumen State Medical University, Ministry of Health of Russia

Email: ludainf03@yandex.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Oksana A. Lyubimtseva

Tyumen State Medical University, Ministry of Health of Russia

Email: loa_1975@mail.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Natalia V. Ogoshkova

Tyumen State Medical University, Ministry of Health of Russia

Email: onw13051978@mail.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Mariya V. Antonova

Tyumen State Medical University, Ministry of Health of Russia

Email: antonovamariav@mail.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

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