THE IMMUNE STATUS OF SCHOOL-AGE CHILDREN WITH AN ACYCLIC COURSE OF TICK-BORNE ENCEPHALITIS DEPENDING ON THE PREMORBID STATE OF THE IMMUNE SYSTEM


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Objective. To study an immune response to changes in the bidirectional (acyclic) course of the meningeal form of tick-borne encephalitis (TBE) in school-age children depending on the presence of clinical signs of immune dysfunction in their histories. Subjects and methods. Examinations were made in 62 children aged 7-14 years at 1, 2, and 3 weeks of acute TBE. Levels 1 and 2 immunological tests were used. Results. The acyclic course of the meningeal form of the disease in school-age children has been established to be accompanied by a change in all components of the immune system. Significant deviations relate to the cellular component of immunity and show as prolonged T lymphopenia, an increase in activation markers (HLA-DR, CD50, CD54, CD38, CD71), and no significant decrease in the number of CD4+ and CD8+ lymphocytes. As viewed from the humoral and nonspecific components of immunity, a reduced number of CD20+ lymphocytes, an elevated level of all immunoglobulin classes, and an enhanced neutrophil phagocytic activity with a scarce functional reserve are typical for most children Conclusion. Children with a history of clinical signs of immune dysfunction as recurrent infection syndrome display a preponderance of activation processes of the cellular and humoral components with a later switch to a secondary immune response.

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作者简介

Eduard Kashuba

Tyumen State Medical University, Ministry of Health of Russia

Email: kashuba.ed@gmail.com
MD, Professor, Department of Infectious Diseases, Allergology, and Immunology with Course of Dermatovenereology and Cosmetology Tyumen, Russia

Olga Rychkova

Tyumen State Medical University, Ministry of Health of Russia

Email: richkovaoa@mail.ru
MD, Head, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Elena Khramova

Tyumen State Medical University, Ministry of Health of Russia

Email: khramova@gmail.com
MD, Head, Department of Childhood Diseases, Faculty of Pediatrics Tyumen, Russia

Lyudmila Khanipova

Tyumen State Medical University, Ministry of Health of Russia

Email: ludainf03@yandex.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Oksana Lyubimtseva

Tyumen State Medical University, Ministry of Health of Russia

Email: loa_1975@mail.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Natalia Ogoshkova

Tyumen State Medical University, Ministry of Health of Russia

Email: onw13051978@mail.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

Mariya Antonova

Tyumen State Medical University, Ministry of Health of Russia

Email: antonovamariav@mail.ru
Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with Course of Dermatology and Cosmetology Tyumen, Russia

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