Correlation assessment of the relationship between selenium levels and some indicators of oxidative stress in the blood serum in patients with tick-borne rickettsiosis in the south of the khabarovsk territory

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. Evaluation of the relationship between selenium (Se) levels and oxidative status in patients with tick-borne rickettsiosis (TBR) caused by R. heilongjiangensis to understand the pathogenesis, assess the severity and possible prognosis of the disease.

Materials and methods. The Se levels and some chemiluminescence indicators in patients with a moderate form of TBR were analyzed.

Results. It was found that the mean blood serum Se level of the examined patients at the height of the disease was statistically significantly reduced, which was combined with a significant initiation of free radical oxidation processes and a sharp suppression of the mobilization of antioxidant antiradical defense. During the period of convalescence in patients with TBR, despite the extinction of the main clinical manifestations of the disease, the activity of free radical oxidation processes continued to increase. Correlation analysis revealed a reliable moderate negative relationship between the chemiluminescent parameters of short-lived reactive oxygen species and the blood serum Se level.

Conclusion. The data obtained indicate the conjugation of the processes of selenium and oxidative status. Se deficiency is reflected in a decrease in the activity of antioxidant antiradical defense.

Full Text

Restricted Access

About the authors

Evgenia V. Mokretsova

Far Eastern State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: bremer68@mail.ru
ORCID iD: 0000-0001-9492-2660

Cand. Med. Sci., Associate Professor, Department of Infectious Diseases and Epidemiology

Russian Federation, Khabarovsk

Gennady S. Tomilka

Far Eastern State Medical University, Ministry of Health of Russia

Email: genntom@mail.fesmu.ru
ORCID iD: 0000-0002-8785-2147

Professor, MD, Head, Department of Infectious Diseases and Epidemiology

Russian Federation, Khabarovsk

Yuri G. Kovalsky

Far Eastern State Medical University, Ministry of Health of Russia

Email: kovalyura@mail.ru
ORCID iD: 0000-0001-7433-6285

Professor, MD, Head, Department of Biological Chemistry and Clinical Laboratory Diagnostics

Russian Federation, Khabarovsk

Natalya Yu. Yakusheva

Far Eastern State Medical University, Ministry of Health of Russia

Email: whiteout@mail.ru
ORCID iD: 0000-0003-1561-5465

Cand. Pharm. Sci., Associate Professor, Department of Pharmacy and Pharmacology

Russian Federation, Khabarovsk

Alexander Yu. Shchupak

Far Eastern State Medical University, Ministry of Health of Russia

Email: schupakalex@mail.ru
ORCID iD: 0000-0001-6255-7638

Cand. Med. Sci., Associate Professor, Head, Department of Clinical Toxicology and Extreme Medicine

Russian Federation, Khabarovsk

Viktor V. Maleev

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: maleyev@pcr.ru
ORCID iD: 0000-0001-5748-178X

Professor, Academician of the Russian Аcademy of Sciences, MD,, Advisor to the Director for Scientific Work

Russian Federation, Moscow

References

  1. Захарычева Т.А., Семенов В.А., Бондаренко Т.Е., Этенко Д.А., Мжельская Т.В., Троценко О.Е. Современный клещевой энцефалит и другие клещевые инфекционные заболевания в Хабаровском крае и Кемеровской области (Кузбассе). Дальневосточный медицинский журнал 2022; (3): 6–12. doi: 10.35177/1994-5191-2022-3-1
  2. Zaharycheva T.A., Semenov V.A., Bondarenko T.E., Jetenko D.A., Mzhel’skaja T.V., Trocenko O.E. [Modern tick-borne encephalitis and other tick-borne infectious diseases in the Khabarovsk Territory and the Kemerovo Region (Kuzbass)]. Far East Medical Journal 2022; 3: 6–12. (In Russ.). doi: 10.35177/1994-5191-2022-3-1
  3. Медянников О.Ю., Макарова В.А. Дальневосточный клещевой риккетсиоз: описание нового инфекционного заболевания. Вестник Российской академии медицинских наук 2008: (7): 41–4.
  4. Medjannikov O.Ju., Makarova V.A. [Far Eastern tick-borne rickettsiosis: description of a new infectious disease]. Annals of the Russian academy of medical sciences 2008: (7): 41–4. (In Russ.).
  5. Bizerea T.O., Dezsi S.G., Marginean O., Stroescu R., Rogobete A., Bizerea-Spiridon O. et al. The Link between Selenium, Oxidative Stress and Pregnancy induced Hypertensive Disorders. Clin. Lab. 2018; 64(10): 1593–1610. doi: 10.7754/Clin.Lab.2018.180307
  6. Русецкая Н.Я., Федотов И.В., Кофтина В.А., Бородулин В.Б. Соединения селена в окислительно-восстановительной регуляции воспаления и апоптоза. Биомедицинская химия 2019; 65(3): 165–79. doi: 10.18097/PBMC20196503165
  7. Ruseckaуa N.Ja., Fedotov I.V., Koftina V.A., Borodulin V.B. [Selenium compounds in the redox regulation of inflammation and apoptosis]. Biomedical Chemistry 2019; 65(3): 165–79. (In Russ.). doi: 10.18097/PBMC20196503165
  8. Palma F.R., He C., Danes J.M., Coelho D.R., Sampaio V.P., Gantner B.N. et al. Mitochondrial Superoxide Dismutase: What the established, the intriguing, and the novel revial about a key cellular redox swich. Antioxid Redox Signal. 2020; 32(10): 701–14. DOI: 10.1089/ ars.2019.7962
  9. Голубкина Н.А., Ковальский Ю.Г., Тармаева И.Ю., Сенькевич О.А. Новые аспекты селенодефицита в России. Материалы XI Международной биогеохимической школы, посвященной 120-летию со дня рождения Виктора Владиславовича Ковальского. Тула: 2019; 32–6.
  10. Golubkina N.A., Koval’sky Yu.G., Tarmaeva I.Yu., Sen’kevich O.A. [New aspects of selenium deficiency in Russia. Materials of the XI International Biogeochemical School dedicated to the 120th anniversary of the birth of Viktor Vladislavovich Kovalsky]. Tula: 2019; 32–6. (In Russ.).
  11. Ковальский Ю.Г., Голубкина Н.А., Папазян Т.Т., Сенькевич О.А. Селеновый статус жителей Хабаровского края, 2018 г. Микроэлементы в медицине 2019; 20(3): 45–53. doi: 10.19112/2413-6174-2019-20-3-45-53
  12. Koval’sky Yu.G., Golubkina N.A., Papazjan T.T., Sen’kevich O.A. [Selenium status of residents of the Khabarovsk Territory, 2018]. Microelements in Medicine 2019; 20(3): 45–53. (In Russ.). doi: 10.19112/2413-6174-2019-20-3-45-53
  13. Lozhkin A, Vendrov A.E., Ramos-Mondragón R., Canugovi C., Stevenson M.D., Herron T.J. et al. Mitochondrial oxidative stress contributes to diastolic dysfunction through impaired mitochondrial dynamics. Redox Biol. 2022; 57: 102474. DOI: 10.1016/ j.redox.2022.102474
  14. Hariharan S., Dharmaraj S. Selenium and selenoproteins: it’s role in regulation of inflammation. Inflammopharmacology. 2020; 28(3): 667–95. doi: 10.1007/s10787-020-00690-x

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Figure. Se level in patients with TBR in the dynamics of the disease Reliability of differences in indicators between groups: р1-2 – 1st and 2end; p1-3 - 1st and 3rd; р2-3 – 2end и 3rd.

Download (147KB)
Indexing metadata

Copyright (c) 2024 Bionika Media