RETROSPECTIVE EPIDEMIOLOGICAL ANALYSIS OF CASES OF PULMONARY TUBERCULOSIS IN PATIENTS WITH MULTIPLE ADMISSIONS TO TUBERCULOSIS HOSPITALS


Дәйексөз келтіру

Толық мәтін

Аннотация

Objective. Molecular epidemiological analysis of cases of pulmonary tuberculosis (TB) and determination of risk factors for TB recurrence and exacerbation in patients with multiple admissions to tuberculosis hospitals. Materials and Methods. 73 serial isolates of Mycobacterium tuberculosis from 34 patients with pulmonary TB (10 - with relapse, 24 - with progression) were subjected to genotyping (spoligotyping, MIRU-VNTR- and IS6110-RFLP-typing). Results. The risk of exogenous infection with multidrug-resistant (MDR) strains of M. tuberculosis was associated with multiple admissions to TB hospitals [OR = 10.5; 95% CI (1.0-108); p = 0.02]. All cases of relapses and 79.2% of cases of the TB progression were caused by M. tuberculosis Beijing strains. Variability in drug susceptibility, as well as in IS6110-RFLP and MIRU-VNTR profiles of serial isolates of M. tuberculosis Beijing strains (B0, A0, and A10 profiles) and LAM9 (SIT252, and SIT150 spoligotypes),the most common in the Russia, were revealed. The variability of the genotypes of serial isolates of M. tuberculosis from 5 (14.7%) of 34 patients was due to mixed infection and/or exogenous infection (presumably during bronchoscopy) in TB hospitals. The risk factor for TB relapse or progression included treatment discontinuation [OR = 6.8; 95% CI (2.7-16.8); p <0.001]. Conclusion. The results of the genotyping and analysis of the spectrum of drug susceptibility of serial isolates of M. tuberculosis from patients with pulmonary TB allow to identify the risk factors for relapse and exacerbation of disease.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Neliia VASILIEVA

Email: sagievanr@gmail.com
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia Saint-Petersburg Scientific Research Institute of Phthisiopulmonology, Ministry of Health of Russia Saint-Petersburg

A. VYAZOVAYA

Email: elmtree2001@mail.ru
Pasteur Scientific Research Institute of Epidemiology and Microbiology Saint-Petersburg

A. INOZEMCEVA

Email: alexashka_11@mail.ru
Saint-Petersburg Scientific Research Institute of Phthisiopulmonology, Ministry of Health of Russia

E. MYASNIKOVA

Email: alexashka_11@mail.ru
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia Saint-Petersburg

L. ZUEVA

Email: uzueva@mail.ru
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia Saint-Petersburg

O. NARVSKAYA

Email: onarvskaya@gmail.com
Pasteur Scientific Research Institute of Epidemiology and Microbiology Saint-Petersburg Scientific Research Institute of Phthisiopulmonology, Ministry of Health of Russia Saint-Petersburg

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