Microbiological monitoring of patients in the infectious intensive care unit

Мұқаба

Дәйексөз келтіру

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Аннотация

Objective. Analysis of microbial colonization data of patients in the intensive care unit (ICU) with assessment of the dynamics of antibacterial resistance.

Materials and methods. An analysis of microbiological monitoring data was performed for 88 patients diagnosed with novel coronavirus infection who were admitted to ICU. Microbiological studies were performed using the standard methodology.

Results. Before admission to the ICU, 27.3% of patients received antimicrobial therapy. The frequency of microbial colonization of various bioloci in patients at admission to the ICU was 93.8% in the contents of the lower respiratory tract, 54.1% in urine, and 35.0% in blood. Normal commensals of the oral cavity and urinary tract were mainly isolated in the contents of the lower respiratory tract and urine. A significant content of Candida fungi was noted – 24.0 and 13.6%, respectively. Staphylococcus spp. were isolated in the blood of patients at admission to the ICU in 71.4% of cases, and Actinomyces spp. In 19.0%. Dynamically, an increase in the frequency of fungal isolation from all loci of patients was noted. Already at admission, some patients (7.6–38.1%) were contaminated with antibiotic-resistant microorganisms; dynamically, a decrease in the isolation of antibiotic-resistant microorganisms isolated from the contents of the lower respiratory tract and blood was noted.

Conclusion. Microbiological monitoring is necessary in the ICU, since it provides early diagnosis of healthcare-associated infections, monitoring the dynamics of the epidemic process and timely prescription of rational antimicrobial therapy.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Oksana Orlova

N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russia; Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Хат алмасуға жауапты Автор.
Email: оksana_orlova@bk.ru
ORCID iD: 0000-0002-6701-1252

MD, Head, Еpidemiology Department; Senior Researcher, Laboratory of Opportunistic Infections; Leading Researcher, Laboratory of Healthcare-Associated Infections

Ресей, Moscow; Moscow; Moscow

Vitaly Gusarov

N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia

Email: gusarovvg@pirogov-center.ru
ORCID iD: 0000-0002-2900-1459

МD, Associate Professor, Chief Physician of the Hospital, Head, Department of Anesthesiology and Resuscitation, Institute for Advanced Medical Training

Ресей, Moscow

Darya Kamyshova

N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia

Email: kamyshovada@pirogov-center.ru
ORCID iD: 0000-0003-3084-9294

Clinical Pharmacologist, Head, Department of Clinical Pharmacology, Assistant Professor, Department of Internal Medicine, Institute for Advanced Medical Training

Ресей, Moscow

Ludmila Petrova

N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia

Email: petrovalv@pirogov-center.ru
ORCID iD: 0000-0001-6221-9743

Bacteriologist, Head, Laboratory of Microbiology

Ресей, Moscow

Tatiana Semenenko

N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russia

Email: info@gamaleya.org
ORCID iD: 0000-0002-6686-9011

Professor, MD, Head, Epidemiology Department; Рrofessor, Department of Infectology and Virology, Institute of Professional Education

Ресей, Moscow

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2. Fig. 1. Dynamics of isolation of the main microorganisms from the lower respiratory tract Here and in Fig. 2 the number of positive research results and the number of studies performed are separated by fractions.

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3. Fig. 2. Dynamics of isolation of the main microorganisms from urine

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