THE PREVALENCE AND FEATURES OF THE MANIFESTATION OF HELICOBACTER PYLORI INFECTION IN THE INDIGENOUS POPULATION OF A SOUTH KAZAKHSTAN REGION

The prevalence and features of the manifestation of Helicobacter pylori (Hp) infection were studied in the indigenous population of South Kazakhstan. Tour hundred and forty-six families from the town of Tenger, South Kazakhstan Region, were followed up. There was evidence that Hp infection was considerably prevalent in the population. The native population was found to have some peculiarities of an Hp-associated inflammatory process in the gastric mucosa (GM), which appeared as its obscure clinical picture, dyspeptic syndrome dominating over pain syndrome: belching (30.7%), discomfort after meals (29.3%), nausea (19.5%), stool impairment (15.7%) and diarrhea (4.8%). The pain syndrome, namely short-term episodes of pain were found in 28.8%, gradually increasing pain in 30.9%, including that radiating to the back in 4.1%. Morphological evidence indicate the frequent development of atrophy even with in the presence of a slight contamination and a mild inflammatory process with the more prolonged sustained course of the pathological process, as well as a marked reduction in the blood and GM levels of ferritin, suggesting impairment of local immune responses. The studies has allowed the author to formulate the distinguishing features ofHp infection in Kazakhs living in a South Kazakhstan region, which will permit an adequate assessment to choose appropriate therapy.

Helicobacter pylori, gastric mucosa, Helicobacter pylori, prevalence, indigenous population, ferritin