QUALITY OF ANTIRETROVIRAL THERAPY IN 2008-2018


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Objective. To investigate the quality of antiretroviral therapy (ART) among patients in the Russian Federation. Materials and methods. The paper analyzes the data on ART, which were obtained from all subjects of Russia in the period of2008-2018 during a special study and from the reporting forms of the Ministry of Health of Russia and the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being. Results. In the period of2008-2018, ART coverage for people living with HIV increased from 10.9 to 38.4%. By the end of 2018, the viral load was below the detection threshold in 73.2% of those receiving ART, which was less than its target value (90%). The proportion of patients starting ART with a CD4+ lymphocyte count of <200cells/pl decreased from 43.6% in 2008 to 16.6% in 2018. That of patients receiving ART regimens including non-nucleoside reverse transcriptase inhibitors rose from 40.1% in 2013 to 68.1% in 2018. Among the patients who initiated ART in 2018, by the end of the year 17.5% stopped it (of them 46.4% did due to death). Of the remaining on ART, its regimen was changed by 20.7% (of them, 40.8 and 19.8% did because of side effects and its inefficiency, respectively). Conclusion. The problem of insufficient ART coverage and late initiation remains relevant. The frequency of ART discontinuation and treatment interruptions remains high. It is expedient to use drugs with a high resistance barrier and good tolerance when starting ART.

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Sobre autores

Oleg YURIN

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: oleg_gerald@mail.ru
МD, Leading Researcher Moscow, Russia

Natalia LADNAIA

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: ladnaia@hotmail.com
Cand. Biol. Sci., Senior Researcher Moscow, Russia

Nadezhda KOZYRINA

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: nad-kozyrina@yandex.ru
Cand. Med. Sci., Senior Researcher Moscow, Russia

Aleksey KRAVCHENKO

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: alexey-kravtchenko@yandex.ru
Prof., МD, Leading Researcher Moscow, Russia

Roza NARSIA

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: rnarsiya@mail.ru
Deputy Head for Economic Affairs and Medical Personnel Management, Specialized Research Department for AIDS Epidemiology and Prevention Moscow, Russia

Ekaterina SOKOLOVA

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: ekaterinasokolova007@rambler.ru
Cand. Med. Sci., Researcher Moscow, Russia

Larisa DEMENTYEVA

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: dementeva_la@gsen.ru
Epidemiology Specialist Moscow, Russia

Vadim POKROVSKY

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: pokrovsky.vad@yandex.ru
Prof., Academician of the Russian Academy of Sciences MD, Head, HIV Department Moscow, Russia

Bibliografia

  1. Global HIV & AIDS statistics - 2019 fact sheet. World AIDS day 2019, UNAIDS, 2019. https://www.unaids.org/en/resources/ fact-sheet
  2. Cohen M.S., Chen Y.O., McCanly M. Prevention of HIV-1 infection witu early antiretroviral therapy. N. Engl. J. Med. 2011; 365(6): 493-505. doi: 10.1136/jfprhc-2012-100379
  3. Newman C.E., de Wit J., Persson A., Holt M., Slavin S., Kidd M.R., Post J.J., Wright E., Мао L. Understanding Concerns About Treatment-as-Prevention Among People with HIV who are not Using Antiretroviral Therapy Understanding Concerns About Treatment-as-Prevention Among People with HIV who are not Using Antiretroviral Therapy. AIDS and Behavior 2014; 19(5). doi: 10.1007/s10461-014-0959-9
  4. Ending AIDS Progress towards the 90-90-90 targets. Global AIDS updates 2017. 196 p. http://ecuo.org/mvdev/wp-content/ uploads/sites/ 4/2017/07/Global_AIDS_update_2017_en-1.pdf
  5. May M.T, Gompels M., Delpech V., Porter K., Orkin Ch., Kegg S. et al. Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. AIDS 2014; 28(8): 1193-202. doi:10.1097/ QAD.0000000000000243.
  6. Marcus J.L., Leyden W., Anderson A.N. et al. Increased overall life expectancy but not comorbidity-free years for people with HIV. Conference on Retroviruses and Opportunistic Infections (CROI). Boston, USA. March 8-11, 2020. Аbstract 151.
  7. Guidelines of HIV mortality measurement. Geneva, Switzerland: Joint United Nations Program of HIV/AIDS and World Health Organization, 2014. https://apps.who.int/iris/ bitstream/handle/10665/127890/9789241505574_eng.pdf;jsessi onid=727FC2B41775C4DE3992886AB23F2B7E?sequence=1
  8. Покровский В.В., Юрин О.Г., Кравченко А.В. и др. Протоколы лечения больных ВИЧ-инфекцией. Национальное научное общество инфекционистов. Эпидемиол. инфекц. болезни. Актуал. вопр. 2011; (3, приложение). 24 с.
  9. Покровский В.В., Юрин О.Г., Кравченко А.В., Беляева В.В., Ермак Т.Н., Канестри В.Г., Шахгильдян В.И., Козырина Н.В., Буравцова Е.Е., Нарсия Р.С., Покровская А.В., Ефремова О.С., Коннов В.В., Куимова У.А., Попова А.А., Хохлова О.Н., Воронин Е.Е., Афонина Л.Ю., Васильева И.А., Зимина В.Н. Национальные рекомендации по диспансерному наблюдению и лечению больных ВИЧ-инфекцией (клинический протокол). Эпидемиол. инфекц. болезни. Актуал. вопр. 2016; (6, приложение). 88 с.
  10. Покровский В.В., Юрин О.Г., КравченкоА.В., Беляева В.В., Ермак Т.Н., Канестри В.Г., Шахгильдян В.И., Козырина Н.В., Буравцова Е.Е., Ладная Н.Н., Нарсия Р.С., Покровская А.В., Ефремова О.С., Коннов В.В., Куимова У.А., Попова А.А., Хохлова О.Н., Воронин Е.Е., Афонина Л.Ю., Васильева И.А., Зимина В.Н. Рекомендации по лечению ВИЧ-инфекции и связанных с ней заболеваний, химиопрофилактике заражения ВИЧ.

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