Methods of Qualitative Express Analysis of>Medicines: Present and Future

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article is a brief overview of the methods used in pharmacy for qualitative rapid analysis of medicines. Methods of identification of active substances in pharmacy conditions are systematized. The analytical capabilities of the methods are compared, their advantages and limitations are indicated. The main prospects for the development of testmethods for the control of the authenticity of medicines are noted. Particular attention is paid to various options for colorimetry, which in the future may become one of the main methods for quickly controlling the authenticity of drugs and monitoring their quality.

Full Text

Restricted Access

About the authors

O. V. Monogarova

МГУ им. М.В. Ломоносова

Author for correspondence.
Email: o_monogarova@mail.ru

к. х. н., химический факультет 

Russian Federation

References

  1. Medicines. Small medical encyclopedia. M.: Medicinskaya Encyclopedia publ. 1991–1996. (in Russ.)
  2. The State Pharmacopoeia of the Russian Federation. XIII edition. 2015. (in Russ.)
  3. Melnikova N. B., Zhiltsova O. E., Bolshakova A. E. Methods for express analysis of drugs manufactured in pharmacies. Tutorial. Nizhniy Novgorod: Izdatelstvo PIMU publ. 2018. 108 p. (in Russ.)
  4. Belikov V. G. Pharmaceutical chemistry. In two parts. Part 1. General pharmaceutical chemistry. Moscow, Vysshaya shkola publ. 1993. 432 p. (in Russ.).
  5. Ermilova E. V., Kadyrova T. V., Dudko V. V. Analysis of medicines of pharmacy and factory production. Tutorial. Tomsk, SibGMU. 2010. 201 p. (in Russ.).
  6. Andreeva T. I., Terentieva S. V. Analysis of dosage forms of pharmacy and factory production. Tutorial. Tomsk. 2001. 151 p. (in Russ.).
  7. Kuleshova M. I., Guseva L. N., Sivitskaya O. K. Analysis of dosage forms manufactured in pharmacies. Manual, second edition, revised and enlarged. Moscow, Medicina publ. 1989. 288 p. (in Russ.).
  8. Dzidzoeva M. I. The use of the refractometry method in pharmaceutical analysis using the example of a glucose solution. Tendencii razvitiya nauki i obrazovaniya = Trends in the development of science and education. 2023; 93(7): 84–86. (in Russ.).
  9. Kasatkin I. A., Slepova O. A., Slepova N. V. The use of refractometry in intra-pharmacy quality control of medicines. Vestnik Permskoj gosudarstvennoj farmacevticheskoj akademii = Bulletin of the Perm State Pharmaceutical Academy. Perm’. 2021; 151–153. (in Russ.).
  10. Glazyrina Yu. A., Saraeva S. Yu., Kozitsyna A. N., Gerasimova E. L., Matern A. I. Optical methods in pharmaceutical analysis: laboratory workshop. Ekaterinburg. 2015. 96 p. (in Russ.)
  11. Karlov V. A., Bulychev A. G. Determination of the optical purity of drugs by polarimetry. Molodoj uchyonyj = Young scientist. 2022; 21(416): 119–123. (in Russ.).
  12. Prokhoda E. F., Golubitskiy G. B., Voinov A. P., Ivanov V. V., Korneeva N. V. Analytical control in the joint-stock company “PHARMSTANDART-LEKSREDSTVA”. Journal of Analytical Chemistry. 2014; 69(10): 1119–1120. (in Russ.).
  13. Bykonya D. I., Isaeva R. G., Kuleshova E. S. Analysis of liquid dosage forms containing one medicinal substance (using glucose as an example) by refractometry. Innovatsiya v sovremennoi nauke = Innovation in modern science. 2019; 140–142. (in Russ.).
  14. Bolotnikova A. A., Utemuradova K., Tishina E. A. Polarimetric method in pharmaceutical analysis. Ekologiya i zdorov’e cheloveka = Ecology and human health. 2022; 7–12. (in Russ.).
  15. Zyuzkova Yu. G., Prokopiev V. E., Udut V. V., Borobieva L. G., Karkishchenko N. N. Possibilities of fluorescent (spectral) express analysis of solid dosage forms. Biomedicina = Biomedicine. 2012; 4: 38–44. (in Russ.).
  16. Ryazanova A. P. Fluorimetric determination of folic acid in drugs. Byulleten’ medicinskikh internet-konferencii = Bulletin of medical internet conferences. 2019; 9(2): 81. (in Russ.).
  17. Nemikhin V. V., Kachin S. V., Kutyakov V. A., Sagalakov S. A. Studies of the spectroscopic properties of codeine for its determination in drugs and biological objects by luminescence and diffuse reflection spectrometry methods. International Journal of Applied and Basic Research. 2019; 11: 126–130. (in Russ.).
  18. Gorelik V. S., Pyatyshev A. Yu. Application of photoluminescent analysis for the control of pharmaceuticals. Vestnik MGTU im. N. E. Baumana. Ser. Estestvennye nauki = Bulletin of N. E. Bauman MSTU. Ser. Natural Sciences. 2012; 2: 12–15. (in Russ.).
  19. Andreev A. I., Kokin S. M., Pautkina A. V., Kharitonov Yu. N. Luminescent analysis as one of the tools of spectrometric quality control. Kachestvo i zhizn’ = Quality and life. 2022; 1(33):46–51. (in Russ.).
  20. Illarionova E. A., Syrovatskiy I. P. Fluorimetry method. Application in pharmaceutical analysis. Tutorial. Irkutsk, IGMU publ. 2017. 41 p. (in Russ.).
  21. Muradkhanov R. R., Mezenova T. D., Dmitriev A. B., Konovalov D. A., Melikova D. N. Determination of podophyllotoxin by planar chromatography. Razrabotka, issledovanie i marketing novoi farmacevticheskoi produktsii = Development, research and marketing of new pharmaceutical products. 2011; 66:428–230. (in Russ.).
  22. Kosenko V. V. Activities of Roszdravnadzor to ensure the quality of drugs. Vestnik Roszdravnadzora = Bulletin of Roszdravnadzor. 2009; 3:4–13. (in Russ..)
  23. Chernousova O. V., Rudakov O. B. Digital imaging in analytical chemistry for quantitative and qualitative analysis. Khimiya, fizika i mekhanika materialov = Chemistry, physics and mechanics of materials. 2019; 2(21):55–125. (in Russ.).
  24. Zhernosek A. K., Avaryaskina I. V. Use of test methods in pharmaceutical analysis (literature review). Vestnik farmacii = Bulletin of Pharmacy. 2009; 44(2): 102–107. (in Russ.).
  25. Kondakov S. E., Melnikov M. Ya., Fedorenko K. G., Prokoptseva O. S. Methodological approaches to the creation of drugs. Rapid screening using universal biosensors at the stage of drug development. Rossiyskii khimicheskii zhurnal = Russian Chemical Journal. 2010; 54(6):60–69. (in Russ.).
  26. Zrelova L. V., Belyaeva E. I., Marchenko D. Yu., Ivanova E. A., Sandzhieva E. A., Dedov A. G. Test methods for the determination of isoniazid. Sbornik tezisov dokladov VII Mezhdunarodnoi konferenstii Rossiyskogo khimicheskogo obshchestva imeni D. I. Mendeleeva, 2015. P. 56. (in Russ.).
  27. Loginova L. P. Test-films for test-determinations on the base of reagents, immobilized gelatinous gel. Talanta. 2008; 77(2): 915–923.
  28. Khan O. Yu., Gnyp K. S., Eremin S. A. Rapid determination of the analgesic morphine by polarization fluorescent immunoassay and immunochromatographic test strips. Vestnik medicinskogo stomatologicheskogo institute = Bulletin of the Medical Dental Institute. 2013; 27(4): 14–18. (in Russ.).
  29. Knyazev D. A., Ivanov M. M., Samokhvalov S. G., Zolotov V. A., Markina V. M., Knyazev V. D. Blister drip-tablet tests for nitrates and nitrites. Journal of Analytical Chemistry. 2002; 57(1):85–92. (in Russ.).
  30. Pezza L., Tubino M., Melios C. B., Pezza L. R. Rapid spot test analysis for the detection of dipyrone in pharmaceutical preparations. Analytical Sciences. 2000; 16(3):313–315.
  31. Marakaeva A. V., Kosyreva I. V. Test determination of amoxicillin in drugs. Izvestiya Saratovskogo universiteta. Novaya seriya. Seriya: khimiya, biologiya, ekologiya = News of the Saratov University. New episode. Series: chemistry, biology, ecology. 2019; 19(2):146–151. (in Russ.).
  32. Tumskaya A. V., Kosyreva I. V. Express determination of cephalexin. Izvestiya Saratovskogo universiteta. Novaya seriya. Seriya: khimiya, biologiya, ekologiya = News of the Saratov University. New episode. Series: chemistry, biology, ecology. 2021; 21(3):260–266. (in Russ.).
  33. Monogarova O. V., Oskolok K. V., Apyari V. V. Colorimetry in chemical analysis. Journal of Analytical Chemistry. 2018; 73(11): 857–867. (in Russ.).
  34. Monogarova O. V., Chaplenko A. A., Oskolok K. V. Multisensory digital colorimetry to identify and determination of active substances in drugs. Sensors and Actuators, B: Chemical. 2019; 299.
  35. Chaplenko A. A., Monogarova O. V., Oskolok K. V. Multisensor colorimetric analysis of dydrogesterone, troxerutin and ademethionine preparations using barcodes. Farmaciya i farmakologiya = Pharmacy and pharmacology. 2021; 9(1):64–72. (in Russ.).
  36. Monogarova O. V., Chaplenko A. A., Oskolok K. V. Identification and determination of chloramphenicol in medicinal products by multisensor digital colorimetry. Vestnik Moskovskogo universiteta. Seriya 2: Khimiya = Moscow University Chemistry Bulletin. Series 2: Chemistry. 2020; 60(1):3–10. (in Russ.).
  37. Chaplenko A. A., Monogarova O. V., Oskolok K. V. Identification of non-steroidal anti-inflammatory drugs by digital colorimetry using the method of principal components. Razrabotka i registratsiya lekarstvennykh sredstv = Development and registration of medicines. 2020; 9(1):55–59. (in Russ.).
  38. Shik A. V., Stepanova I. A., Doroshenko I. A., Podrugina T. A., Beklemishev M. K. Carbocyanine-based fluorescent and colorimetric sensor array for the discrimination of medicinal compounds. Chemosensors. 2022; 10(2): 88–103.
  39. Amelin V. G., Shaoka Z. A. Ch., Bolshakov D. S., Tretyakov A. V. Digital colorimetry of indicator test systems using a smartphone and chemometric analysis in the determination of quinolones in drugs. Journal of Applied Spectroscopy. 2022; 89(1): 84–93. (in Russ.).
  40. Baydicheva O. V., Rudakova L. V., Rudakov O. B. Application of digital technologies in color tests of biologically active substances. Butlerovskie soobshcheniya = Butlerov messages. 2008; 13(2):50–61. (in Russ.).
  41. Buzuk G. N., Kuzmicheva N. A. Colorimetric and densitometric methods of analysis in the standardization of Ascorutin and Rutascorbin tablets. Vestnik farmacii – Bulletin of Pharmacy. 2011; 3(53):12–18. (in Russ.).
  42. Gorbunova M. V., Safronova A. S., Vasileva A. A., Spitsyna K. S., Apyri V. V., Dmitrienko S. G. Sulfonamide drugs: Lost cost spectrofluorimetric determination using a computer monitor calibrator for detection. Talanta. 2023; 124383.
  43. Gorbunova M. V., Terntev T. A., Apyari V. V., Dmitrienko S. G., Zolotov Yu. A. Monitor calibrator as an alternative to spectrofluorimeter: determination of quinine in beverages and medicinal preparations. Journal of Analytical Chemistry. 2023; 78(3): 223–230. (in Russ.).
  44. Akhtera S., Basirulina W., Aliasa Y., Johanb M., Bagherid S., Shalauddinb M., Ladane M., Anuar M. Enhanced amperometric detection of paracetamol by immobilized cobalt ion on functionalized MWCNTs-Chitosan thin film. Analytical Biochemistry. 2018; 551:29–36.
  45. Shaw L., Dennany L. Applications of electrochemical sensors: Forensic drug analysis. Current opinion in electrochemistry. 2017; 3:23–28.
  46. Shumyantseva V. V., Bulko T. V., Koroleva P. I. Methods for the analysis of drugs. Biomedical Chemistry: Research and Methods. 2019; 2(4):1–7.
  47. Rahimi-Nasrabadi M., Khoshroo A., Mazloum-Ardakani M. Electrochemical determination of diazepam in real samples based on fullerene-functionalized carbon nanotubes/ionic liquid nanocomposite. Sensors and Actuators, B: Chemical. 2017; 240:125–131.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Monogarova O.V.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies