Exposome and chemists

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Abstract

This article is an overview description of exposomics that is a concept and a modern field of biomedical and chemical-analytical research related to the study of the integrity of various exposures to a human body over a long time period. The complicated structure and components of an exposome
are considered. The external and internal exposomes and their chemical components, including exogenous compounds, products of their biotransformation and endogenous metabolites, are identified. It is indicated that the development of exposomics in its chemical aspects is based on the use of nontarget chemical analysis techniques, including various
variants of chromatography and mass spectrometry. The development of data science is characterized, the consequence of which is the emergence of numerous databases in which the relationship between various chemical compounds and certain diseases is outlined. The goals of exposomal research that are or should be carried out by analytical chemists

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About the authors

B. L. Milman

ФГБУ НКЦТ им. С. Н. Голикова ФМБА России

Email: bormilman@yandex.ru

д. х. н

Russian Federation

I. К. Zhurkovich

ФГБУ НКЦТ им. С. Н. Голикова ФМБА России

Author for correspondence.
Email: bormilman@yandex.ru

к. х. н.

Russian Federation

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Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. To the original concept of the exposome, introduced in the works of Wild [2]. The exposome is postulated to include every exposure to which an individual is exposed from conception to death

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3. Fig. 2. Various components of the exposome, considered as the concept of exposomics develops [4]

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4. Fig. 3. Part of the information about genistein [18], an organic compound of plant origin. Its structural formula and statistics of the corresponding exposome data are shown. Associations of genistein as a biomarker with samples analyzed and its effect on cancer were noted

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Copyright (c) 2023 Мильман Б.Л., Журкович И.К.

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