COMPARATIVE STUDY OF THE INDLUENCE OF PYATD1 COMPOUND AND DAPSONE DRUG ON THE MOTION AND EXPLORATORY ACTIVITY OF BOTH SEX RATS IN THE “OPEN FIELD” TEST

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Nowadays, the defects in nervous system are the most frequent side effects connected with the application of antimicrobial drugs. This causes the formation of psychopathological changes which significantly lowers a life quality sometimes leading to a signified stable maladap-tation. The purpose of the work is a comparative study for the influence of PYATd1 compound and dapsone drug on a motion and exploratory activity of both genders rats in a chronic experiment. Materials and methods of the study: the experiment was carried out using 60 white Wistar rats of both sexes weighed 190-205 g. After two-days quarantine animals were divided into 6 groups by 10 animals each. Comparison drug and PYATd1 compound was delivered to the animals through the sound into their stomach 1 time a day in the mornings during 30 days at dose 25 mg/kg. Motion and explorative activities were evaluated in the “open field” test. Statistic processing and analysis of the study results were carried out using StatPlus 2009 program, implementing traditional methods of variation deviations. Results: in a month after the administra-tion of the dapsone drug animals showed statistically relevant decrease of number of visited squares in comparison with control groups of animals. Female rats had a decrease by -29.82% (Pk<0.001), male rats had a decrease by -50.94% (Pk<0.001), and a number of free stands of female rats decreased by -79.17% (Pk<0.01), of male rats by -25.68% (Pk<0.001) and the number of free stands for female rats decreased by -70.83% (Pk<0.01), in comparison with control groups of animals. After the administration of dapsone drug time of grooming decreased by -77.05% (Pk<0.02), however the freezing time increased 16 times (Pk<0.001) comparing with animal control group. After the administration of PYATd1 compound male rats showed the decrease of grooming time by 81.97% (Pk<0.01), with that the freezing period remained the same comparing with control animal group. Locomotor and vertical orientation and explora-tory activity decrease and freezing time increase may be an evidence of the reduction of intellectual and mnestic functions of rats which is expressed in anxiety, fear, and emotional discomfort. Conclusions: we have established that 30-day administration of the dapsone drug leads to the suppression of motion and searching activity of the experimental animals, while PYATd1 compound did not show a significant influence on the indices under study.