PECULIARITIES OF THE COMPLICATIONS EXPANSION OF PSYCHOPHARMACOTHERAPY OF WOMEN WITH DEPRESSIVE DISORDERS: ETHNIC ASPECTS (ON THE EXAMPLE OF STAVROPOL KRAI)

Abstract

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Purpose of the work was to reveal the ethnic peculiarities of the complications expansion of psychopharmacotherpay in female patients with depressive disorders. Materials and methods of the study: we have analyzed clinical records of the female patients of Stavropol krai clinical lunatic asylum no. 1 (2012 - 2015), who suffered depressive disorders, representatives of Armenian, Nogai, and Turkmen ethnic groups. Ethnicity without mixed marriages up to 3rd generation (established in an oral survey) and verified diagnosis of depressive disorders (F30 - F34; by ICD-10) were the insertion criteria into the study. Disregard criteria included 1) age restrictions (not older than 60, the upper limit was conditioned by the aim to reduce the distorting influence on the clinic picture of the main disease); 2) associated diseases, which significantly influence the pharmacokinetics and pharmacodinamics of drugs: heavy affections of liver and kidneys, cholecystitis; 3) endocrine diseases (achrestic diabetes, thyroid gland diseases); 4) heavy somatic disturbances (myocardial infarction etc); 5) addiction to psychoactive substances (alcohol, drug abuse, toxicomania); 6) inflectional diseases - AIDS, HIV infection, tuberculosis, malaria); 7) compulsory treatment; 8) diagnosis of schizophrenia, schizoaffective disorder. Demographic data of female patients, main psychiatric diagnosis, associated pathological conditions, psychopharmacotherapy conducted, its efficacy, frequency and heaviness of complications were entered into clinical records. The data obtained were processed statistically by using the package of standard computer programs. The regularity of the distribution was estimated by using Shapiro-Wilk W-criterion. Statistically significant parametric differences were discovered using Student’s criterion, non-parametric differences were revealed using criteria of Kruskal-Wallis, Mann-Whitney, Wilcoxon, Z, Chi-squared test. Results: this paper presents the analysis of progressing complications of psychopharmacotherapy. Most frequently undesirable reactions appeared in Armenian patients. All the representatives of the group (100%) had arterial tension fall (AT) and somnolency during day time; three women manifested one more complication each: irritation, air hunger, tearfulness. Nogai women, in spite of the less variability of complication pattern in comparison with Armenian and Turkmen women manifested a high frequency of AT fall (32 patients, 96%), tearfulness (10 patients, 30%), air hunger (1 patient). Undesirable reactions were more variable in Turkmen patients, although they were registered more rarely: tearfulness (3 patients); air hunger (2 women), apathy, inappetence, retardation, anxiety dreams (by one complication). Conclusions: thus, the results obtained can become a basis for the working out of measurements for the improvement of psychophramacotherapy of patients with depressions considering their ethnicity.