Vol 1, No 1 (2013)

Search for new applications of known drugs is unique among methods of finding drugs. Significant savings is the benefit of this approach. Known drugs are well studied, change their application does not require extensive research accompanying the introduction of the pharmaceutical market of new substances. In this paper, an example of extending the scope of known drugs is shown by the example of promising research in a number of well-known disaggregants drugs using techniques of molecular modeling, quantum chemistry and multivariate statistical analysis.

The article presents information on the formation Botanical Garden at Pyatigorsk Pharmaceutical Institute, the history of its formation, the current status of the collection. Indicated perspective directions of development the Botanical Garden as a scientific and cultural center of Pyatigorsk.

The analysis of the range of the medicines presented by the pharmaceutical company «Servier » in the Russian market, applied is carried out at treatment of a wide range of diseases. The expert assessment of a pharmacoepidemiology approach is carried out during the developing, introduction and a promotion of medicines. Adaptation of innovative methods of formation of product range and the range taking into account a pharmacoepidemiology for domestic pharmaceutical companies is made.

Increasing attention is being given in the official medicine use of plant origin for the prevention and treatment of early stages of disorders of the cardiovascular system, including oxycinnamic acids. The flow rate of cerebral blood flow were recorded by the standard method using hydrogen clearance implanted platinum electrodes placed on the surface of brain sagittal sinus drain region in the sinuses. Caffeic and ferulic acid in the course application significantly increase the level of cerebral blood flow rate in the animals in the experimental rules. Caffeic and ferulic acid at course prophylactic use for 14 days significantly reduced the severity of cerebrovascular pathological phenomena (hyperperfusion and hypoperfusion), which significantly reduces the risk of tissue edema of the nervous system during the first phase - hyperperfusion and also reduces the mortality rate of animals during the second phase - hypoperfusion.

Based on the measured IR and H 1NMR spectra of the substance 4-amino-3-(3-pyridyl)-butanoic acid dihydrochlorid carried interpretation of absorption and structural fragments installed analyte. The results led to the recommendation of these research methods to be used in pharmaceutical analysis as a substance and a drug for structure determination and identification of the substance.