FORECASTING AND EXPERIMENTAL DETERMINATION OF DESTRUCTION IMPURITIES AND IN THE PHARMACEUTICAL COMPOSITION OF THE HYPOTENSIVE ACTION
- 作者: Kompantseva E.V.1, Babyak A.V.1, Mudretsova Y.V.1, Glushko A.A.1
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隶属关系:
- Pyatigorsk Medical and Pharmaceutical Institute – a branch of the Volgograd State Medical University
- 期: 卷 1, 编号 1 (2013)
- 页面: 18-23
- 栏目: Articles
- URL: https://journals.eco-vector.com/2307-9266/article/view/111204
- ID: 111204
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全文:
详细
Determination results of impurities verapamil hydrochloride and lisinopril dihydrate using computer modeling and HPLC coupled with mass spectrometry (HPLC-MS) reported in this article. Prediction and calculation of the thermodynamic characteristics of the substances carried by the method of RM1 and programs HyperChem. Mass spectrometric analysis was performed on a quadrupole mass analyzer in the recording mode of the positive ions within the range m / z 100-1000. The study found that described in the regulations extraneous verapamil and lisinopril are the products of degradation of materials. Prediction of degradation products of lisinopril dihydrate fully confirmed the data of the ion current chromatograms and mass spectra of the substances. However, in the case of verapamil simulation results coincided with the degradation products by HPLC-MS analysis for two of the four predicted substances.
全文:
ПРОГНОЗИРОВАНИЕ И ЭКСПЕРИМЕНТАЛЬНОЕ ОПРЕДЕЛЕНИЕ ПРИМЕСЕЙ И ПРОДУКТОВ ДЕСТРУКЦИИ В ФАРМАЦЕВТИЧЕСКОЙ КОМПОЗИЦИИ ГИПОТЕНЗИВНОГО ДЕЙСТВИЯ×
作者简介
Evgenia Kompantseva
Pyatigorsk Medical and Pharmaceutical Institute – a branch of the Volgograd State Medical University
Email: dskompanceva@mail.ru
Pyatigorsk
Anna Babyak
Pyatigorsk Medical and Pharmaceutical Institute – a branch of the Volgograd State Medical University
Email: annav.babyak@gmail.com
Pyatigorsk
Yulia Mudretsova
Pyatigorsk Medical and Pharmaceutical Institute – a branch of the Volgograd State Medical University
Email: mydraya.yuliya@yandex.ru
Pyatigorsk
Aleksandr Glushko
Pyatigorsk Medical and Pharmaceutical Institute – a branch of the Volgograd State Medical University
Email: saha-omega@yandex.ru
Pyatigorsk
参考
- Погребняк А.В. Молекулярное моделирование и дизайн биологически активных веществ. – Ростов-на-Дону: СКНЦ ВШ, 2003. – 232 с.
- Gerd B. Rocha.RM1: A reparameterization of AM1 for H, C, N, O, P, S, F, Cl, Br, and I // J. of Computational Chemistry. – 2006. – Vol. 27, №10. – P. 1101-1111.
- Компанцева Е.В. Использование метода тонкослойной хроматографии для определения верапамила гидрохлорида, лизиноприла дигидрата и продуктов их деструкции при совместном присутствии // Научные ведомости Белгородского государственного университета. – 2012.-Т.135,№16.-С.123-127.
- Эпштейн Н.А. Оценка пригодности (валидация) ВЭЖХ методик в фармацевтическом анализе (обзор) // Хим.-фармац. журн. – 2004. – Т.38, №4. – С. 40–56.
- Бабьяк А.В. Расчет термодинамических характеристик и прогнозирование процессов деструкции верапамила гидрохлорида и лизиноприла дигидрата // Разработка, исследование и маркетинг новой фармацевтической продукции: сб. науч. тр.- Пятигорск, 2012.- Вып. 67. – С. 210-213.
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