ANALYSIS OF THE EFFICACY OF THE USE OF NEURALLY MEDIATED AMINOACIDS DERIVATIVES IN CONDITIONS OF ACUTE HEMIC HYPOXIA

Abstract

Full Text

Purpose of the work: analysis and comparison of the effect of derivatives antihypoxic neurally mediated acids with officinal antihypoxant Mexidol in acute hemic hypoxia. Materials and methods of the study: a model of the acute hemic hypoxia which was reproduced by using methemoglobin forming, achieved by means of intragastric administration of sodium nitrite at a dose of 200 mg/kg into male mice weighed 18-20 g. We examined phosphorylated derivatives of glycine (ACF 90-7), GABA (89-5 ACF), aspartic acid (PIR 89-6-A), beta-alanine (N-acetyl-beta-alanine (100 mg/kg) ACF 89-4), and a magnesium salt of taurine, N-acetyltaurine-magnesium, deanol acetylglumate, acetyl asparaginic acid, deanol acetylglumate (50 mg/kg). Objects of the study and reference drug of Mexidol were administered in doses of 1, 10, 50 and 100 mg/kg intragastrically 30 min before the administration of the toxic agent. Each group (test, control) had 10 animals. Results: we have found that the prophylactic use of Mexidol in conditions of hemic hypoxia increased survival of the animals at doses of 5 mg/kg (23.4%) and 100 mg/kg (35.2%). While comparing antihypoxic effect on hemic hypoxia model of ad officinal antihypoxant and neuroprotective effect with the amino acid derivative we have established that the effect is stronger after the use of the following compounds: ACF 90-7 (100 mg/kg) 89-5 ACF (10, 50 and 100 mg/kg) PIR 89-6-O (50 and 100 mg/kg), 2-aminosulphonate magnesium (1,10,50 and 100 mg/kg), DMAE (100mg/kg), deanol acetylglumate (1 mg / kg) N- acetyl asparaginic acid (50 and 100 mg/kg). W should noted that the anti-hypoxic effect is comparable with Mexidol in the application of the following compounds: N-acetyl-beta-alanine (100mg/kg) ACF 89-4 (100mg/kg) 89-5 ACF (1 mg/kg), PIR 89- 6-D (10 mg/kg), taurine (1 and 10 mg/ kg), N- acetyltaurine -magnesium (50 and 100 mg/kg), deanol acetylglumate (50 mg/kg) Conclusions: the analysis of the prospects of the use of derivatives neurally mediated acids glycine, beta-alanine, GABA, taurine, glutamic, and aspartic amino acids under conditions of methemoglobinemia in comparison with the official Mexidol antihypoxant. We have shown that glycine derivatives, GABA, aspartic acid, taurine, glutamic acid and acetyl asparaginic acid have a more pronounced effect in terms antihypoxant sodium nitrite intoxication than succinate-bearing comparator at the maximally effective dose of 100 mg/kg.