BIOLOGICAL ACTIVITY OF THE COMPONENTS OF ROYAL JELLY AND BEE VENOM


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Abstract

Both bee products themselves and their combinations are widely represented in the domestic pharmaceutical market, however, modern experimental studies of the biological activity of these compounds are few, and in many of the existing publications the authors describe an extremely wide and controversial range of therapeutic effects. The aim of the study is to analyze the experimental works on the study of biological activity of bee products. Materials and methods. The study was conducted using search and information (eLibrary, PubMed, CyberLeninka, ResearchGate) and library databases (Russian State Library, Central Scientific Agricultural Library). In the designated databases, publications were searched by such terms as “biological activity”, “royal jelly”, etc. The depth of the search was not limited. Results and discussion. The analysis of the published works shows that such substances as bee venom and royal jelly have experimentally confirmed their biological activity. In both cases, the active substances have been described and a review of their detected biological activity has been carried out. Conclusion. The authors suggest that when developing the method of laboratory synthesis of decene acids, it can be possible to carry out their large-scale preclinical research, which may become the basis for the creation of a drug with a selective effect.

About the authors

S. G. Mardanly

State University of Humanities and Technology; CJSC “Ecolab”

Email: ekolab-president@mail.ru

V. V. Pomazanov

State University of Humanities and Technology; CJSC “Ecolab”

Email: alliya2005@yandex.ru

V. A. Kiseleva

State University of Humanities and Technology

Email: fammgogi@mail.ru

Ya. B. Neskorodov

CJSC “Ecolab”

Email: NeskorodovYB@gmail.com

References

  1. Drews J. Drug discovery: a historical perspective // Science. – 2000. – Vol. 287. № 5460. – P. 1960–1964. doi: 10.1126/science.287.5460.1960.
  2. Баренбойм Г.М., Маленков А.Г. Биологически активные вещества: Новые принципы поиска. – M.: Наука. 1986. – 362 с.
  3. Уроженко О.А. Апитерапия – лечение продуктами пчеловодства. – М.: ДеЛи принт, 2003.– 6 с.
  4. Рылова А.В., Лубнин А.Ю. Влияние анестезии ксеноном на кислородный статус и метаболизм головного мозга у нейрохирургических больных // Анестезиология и реаниматология. – 2011. № 4. – С. 17–21.
  5. Adolf von Planta A. Ueber den Futtersaft der Bienen // Zeitschrift für physiologische Chemie. – 1888. – Т. 12. № 4. – P. 327–354.
  6. Johansson T.S.K. Royal jelly // Bee World. – 1955. – Vo l. 36. № 2. – P. 21–32.
  7. Townsend G.F., Lucas C.C. The chemical nature of royal jelly // Biochemical Journal. – 1940. – Vo l. 34. № 8–9. – P. 1155.
  8. Lercker G., Capella P., Conte L.S., Ruini F., Giordani G. Components of royal jelly: I. Identification of the organic acids // Lipids. – 1981. – Vo l. 16. №12. – P. 912–919.
  9. Noda N., Umebayashi K., Nakatani T., Miyahara K., Ishiyama K. Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera) // Lipids. – 2005. – Vo l. 40. № 8. – P. 833–838. https://doi.org/10.1007/s11745-005-1445-6.
  10. McCleskey C.S., Melampy R.M. Bactericidal properties of royal jelly of the honeybee // Journal of Economic Entomology. – 1939. – Vo l. 32. – № 4. – P. 581–587.
  11. Krasikova V.I. Bactericidal properties of brood food // Pchelovodstvo. – 1955. – Vo l. 32. № 8. – С. 50–53.
  12. Abbott O.D., French R.D. Chemical composition and physiological properties of royal jelly. Agricultural experiment station. Annual report. University of Florida. 1945 June 30; P. 69. http://ufdc.ufl.edu/UF00027385/00031/1x.
  13. Blum M.S., Novak A.F., Taber S. 10-hydroxy-Δ2-decenoic acid, an antibiotic found in royal jelly // Science. – 1959. – Vo l. 130. №3373. – Р. 452–453.
  14. National Center for Biotechnology Information. PubChem Compound Database; CID=5280963, https://pubchem.ncbi.nlm.nih.gov/compound/5280963 (accessed Nov. 9, 2016).
  15. Butenandt A., Rembold H. Über den Weiselzellenfuttersaft der Honigbiene I. Isolierung, Konstitutionsermittlung und Vorkommen der 10-Hydroxy-Δ2-decensäure // Hoppe-Seyler´s Zeitschrift für physiologische Chemie. – 1957. – Vo l. 308,№1. – Р. 284–289.
  16. Barker S.A., Foster A.B., Lamb D.C. Identification of 10-Hydroxy-Delta2-decenoic Acid in Royal Jelly // Nature. – 1959. – Vo l. 183, – Р. 996–997.
  17. Immerseel F.V., Buck J.D., Boyen F., Bohez L., Pasmans F., Volf J., Sevcik M., Rychlik I., Haesebrouck F., Ducatelle R. Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis // Applied and Environmental Microbiology. – 2004. – Vo l. 70, № 6. – Р. 3582–3587. doi: 10.1128/AEM.70.6.3582-3587.2004.
  18. National Center for Biotechnology Information. PubChem Compound Database; CID=8892, https://pubchem.ncbi.nlm.nih.gov/compound/8892 (accessed Nov. 15, 2016).
  19. National Center for Biotechnology Information. PubChem Compound Database; CID=379, https://pubchem.ncbi.nlm.nih.gov/compound/379 (accessed Nov. 15, 2016).
  20. National Center for Biotechnology Information. PubChem Compound Database; CID=2969, https://pubchem.ncbi.nlm.nih.gov/compound/2969 (accessed Nov. 15, 2016).
  21. National Center for Biotechnology Information. PubChem Compound Database; CID=5312738, https://pubchem.ncbi.nlm.nih.gov/compound/5312738 (accessed Nov. 14, 2016).
  22. National Center for Biotechnology Information. PubChem Compound Database; CID=74300, https://pubchem.ncbi.nlm.nih.gov/compound/74300 (accessed Nov. 25, 2016).
  23. National Center for Biotechnology Information. PubChem Compound Database; CID=1713086, https://pubchem.ncbi.nlm.nih.gov/compound/1713086 (accessed Nov. 14, 2016).
  24. Kodai T., Nakatani T., Noda N. The absolute configurations of hydroxy fatty acids from the royal jelly of honeybees (Apis mellifera) // Lipids. – 2011. – Vo l. 46, № 3. – Р. 263–270. https://doi.org/10.1007/s11745-010-3497-x.
  25. National Center for Biotechnology Information. PubChem Compound Database; CID=18408222, https://pubchem.ncbi.nlm.nih.gov/compound/18408222 (accessed Nov. 14, 2016).
  26. National Center for Biotechnology Information. PubChem Compound Database; CID=26612, https://pubchem.ncbi.nlm.nih.gov/compound/26612 (accessed Nov. 14, 2016).
  27. National Center for Biotechnology Information. PubChem Compound Database; CID=5192, https://pubchem.ncbi.nlm.nih.gov/compound/5192 (accessed Nov. 14, 2016).
  28. Белов А.Е., Исмагилова А.Ф. Эффективность применения 9-оксо-2Е-деценовой кислоты для лечения мастита у коров и получения молока высокого санитарного качества // Вестник Башкирского государственного аграрного университета. – 2012. – С. 20–21.
  29. National Center for Biotechnology Information. PubChem Compound Database; CID=12560, https://pubchem.ncbi.nlm.nih.gov/compound/12560 (accessed Nov. 25, 2016).
  30. National Center for Biotechnology Information. PubChem Compound Database; CID=5904, https://pubchem.ncbi.nlm.nih.gov/compound/5904 (accessed Nov. 25, 2016).
  31. National Center for Biotechnology Information. PubChem Compound Database; CID=5999, https://pubchem.ncbi.nlm.nih.gov/compound/5999 (accessed Nov. 25, 2016).
  32. National Center for Biotechnology Information. PubChem Compound Database; CID=5340, https://pubchem.ncbi.nlm.nih.gov/compound/5340 (accessed Nov. 25, 2016).
  33. Townsend G.F., Morgan J.F., Hazlett B. Activity of 10-hydroxydecenoic acid from royal jelly against experimental leukaemia and ascitic tumours // Nature. – 1959. – Vo l. 183, № 4670. – Р. 1270–1271.
  34. Townsend G.F., Morgan J.F., Tolnai S., Hazlett B., Morton H.J., Shuel R.W. Studies on the in vitroantitumor activity of fatty acids I. 10-hydroxy-2-decenoic acid from royal jelly // Cancer research. – 1960. – Vo l. 20, № 4. – Р. 503–510.
  35. Townsend G.F., William H.B., Felauer E.E., Barbara H. Studies on the in vitroantitumor activity of fatty acids: IV. The esters of acids closely related to 10-hydroxy-2-decenoic acid from royal jelly against transplantable mouse leukemia // Canadian journal of Biochemistry and Physiology. – 1961. – Vo l. 39, № 11. – Р. 1765–1770.
  36. Tolnai S., Morgan J. F. Studies on the in vitroantitumor activity of fatty acids: v. Unsaturated acids // Canadian journal of biochemistry and physiology. – 1962. – Vo l. 40, № 7. – Р. 869–875.
  37. Elnagar S. A. Royal jelly counteracts bucks’ “summer infertility” // Animal reproduction science. – 2010. – Vo l. 121, №1. – Р. 174–180. https://doi.org/10.1016/j.anireprosci.2010.05.008.
  38. Mishima S., Suzuki K.M., Isohama Y., Kuratsu N., Araki Y., Inoue M., Miyata T. Royal jelly has estrogenic effects in vitroand in vivo // Journal of ethnopharmacology. – 2005. – Vo l. 101, №1. – Р. 215–220. https://doi.org/10.1016/j.jep.2005.04.012.
  39. Kohguchi M., Inoue S., Ushio S., Kurimoto M. Effect of royal jelly diet on the testicular function of hamsters // Food science and technology research. – 2004. – Vo l. 10. – № 4. – Р. 420–423. https://doi.org/10.3136/fstr.10.420.
  40. Yang A., Zhou M., Zhang L., Xie G., Chen H., Liu Z., Ma W. Influence of royal jelly on the reproductive function of puberty male rats // Food and chemical toxicology. – 2012. – Vo l. 50. – № 6. – Р. 1834–1840. https://doi.org/10.1016/j.fct.2012.02.098.
  41. Zahmatkesh E., Najafi G., Nejati V., Heidari R. Protective effect of royal jelly on the sperm parameters and testosterone level and lipid peroxidation in adult mice treated with oxymetholone // Avicenna journal of phytomedicine. – 2014. – Vol. 4, № 1. – Р. 43.
  42. National Center for Biotechnology Information. PubChem Compound Database; CID=5281034, https://pubchem.ncbi.nlm.nih.gov/compound/5281034 (accessed Nov. 17, 2016).
  43. Kind F.A., Maqueo M., Dorfman R.I. Influence of various steroids on testes and accessory sex organs in the rat // Acta endocrinologica. – 1965. – Vo l. 49, № 1. – Р. 145–154. DOI: https://doi.org/10.1530/acta.0.0490145.
  44. Zahmatkesh E., Najafi G., Nejati V. Protective effect of royal jelly on in vitrofertilization (ivf) in male mice treated with oxymetholone // Cell Journal (Yakhteh). – 2015. – Vo l. 17, № 3. – Р. 569. doi: 10.22074/cellj.2015.19.
  45. National Center for Biotechnology Information. PubChem Compound Database; CID=6623, https://pubchem.ncbi.nlm.nih.gov/compound/6623 (accessed Nov. 24, 2016).
  46. Takeuchi T., Tsutsumi O., Ikezuki Y., Takai Y., Taketani Y. Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction // Endocrine journal. – 2004. – Vo l. 51, № 2. – Р. 165–169. https://doi.org/10.1507/endocrj.51.165.
  47. Nakaya M., Onda H., Sasaki K., Yukiyoshi A., Tachibana H., Yamada K. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells // Bioscience, biotechnology, and biochemistry. – 2007. – Vo l. 71, № 1. – Р. 253–255. https://doi.org/10.1271/bbb.60453.
  48. Yang X.Y., Yang D.S., Wei-Zhang, Wang J.M., Li C.Y., Hui-Ye, Lei K.F., Chen X.F., Shen N.H., Jin L.Q., Wang J.G. 10-Hydroxy-2-decenoic acid from Royal jelly: a potential medicine for RA // Journal of ethnopharmacology. – 2010. – Vo l. 128, № 2. – Р. 314–321. https://doi.org/10.1016/j.jep.2010.01.055.
  49. Исмагилова А.Ф., Белов А.Е. Влияние синтетического препарата 9-ОДК на качество спермы хряков // Ученые записки Казанской государственной академии ветеринарной медицины им. Н.Э.Баумана. – 2012. – С.210.
  50. Крылова Е.В., Потемкина Т.Е., Корягин А.С., Нестеров Г.Д. Профилактическое действие маточного молочка пчел на показатели сперматогенеза крыс при остром тепловом стрессе // Вестник Нижегородского университета им. Н.И. Лобачевского. – 2011. – Т. 6, – №1. – С. 138–142.
  51. Kanter M., Aktas C., Erboga M. Curcumin attenuates testicular damage, apoptotic germ cell death, and oxidative stress in streptozotocin induced diabetic rats // Molecular nutrition & food research. – 2013. – Vo l. 57. – № 9. – Р. 1578–1585.
  52. Seethalakshmi L., Menon M., Diamond D. The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat // The Journal of urology. – 1987. – Vo l. 138. – № 1. – Р. 190–194. https://doi.org/10.1016/S0022-5347(17)43042-4.
  53. Cameron D.F., Murray F.T., Drylie D.D. Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men // The Anatomical Record. – 1985. – Vo l. 213. – № 1. – Р. 53–62. https://doi.org/10.1002/ar.1092130108.
  54. Sadik N.A.H., El-Seweidy M.M., Shaker O.G. The antiapoptotic effects of sulphurous mineral water and sodium hydrosulphide on diabetic rat testes // Cellular Physiology and Biochemistry. – 2011. – Vo l. 28. – № 5. – Р. 887–898. https://doi.org/10.1159/000335803.
  55. National Center for Biotechnology Information. PubChem Compound Database; CID=29327, https://pubchem.ncbi.nlm.nih.gov/compound/29327 (accessed Nov. 18, 2016).
  56. Karaca T., Demirtaş S., Karaboğa İ., Ayvazz S. Protective effects of royal jelly against testicular damage in streptozotocin-induced diabetic rats // Turkish journal of medical sciences. – 2015. – Vo l. 45, – №1. – Р. 27–32. doi: 10.3906/sag-1311-103.
  57. Johnsen S.G. Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males // Hormone Research in Paediatrics. – 1970. – Vo l. 1, – №1. – Р. 2–25. https://doi.org/10.1159/000178170.
  58. S. Hidaka, Y. Okamoto, S. Uchiyama, A. Nakatsuma, K. Hashimoto, S.T. Ohnishi, M. Yamaguchi. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model // Evidence-based complementary and alternative medicine. – 2006. – Vo l. 3, – № 3. – Р. 339–348. http://dx.doi.org/10.1093/ecam/nel019.
  59. National Center for Biotechnology Information. PubChem Compound Database; CID=9859090, https://pubchem.ncbi.nlm.nih.gov/compound/9859090 (accessed Nov. 14, 2016).
  60. Moutsatsou P., Papoutsi Z., Kassi E., Heldring N., Zhao C., Tsiapara A., Melliou E., Chrousos G.P., Chinou I., Karshikoff A., Nilsson L., Dahlman-Wright K. Fatty acids derived from royal jelly are modulators of estrogen receptor functions // PLoS One. – 2010. – Vo l. 5, – № 12. – Р. e15594. https://doi.org/10.1371/journal.pone.0015594.
  61. Feldman E. Thiobarbituric acid reactive substances (TBARS) assay // AMDCC Protocols, Version. – 2004. – Vo l. 1. – Р. 1–3.
  62. Azab K.S., Bashandy M., Salem M., Osama A., Tawfik Z., Helal H. Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats // North American journal of medical sciences. – 2011. – Vo l. 3, – №6. – Р. 268. doi: 10.4297/najms.2011.3268.
  63. National Center for Biotechnology Information. PubChem Compound Database; CID=16133648, https://pubchem.ncbi.nlm.nih.gov/compound/16133648 (accessed Dec 5, 2016).
  64. Moreno M., Giralt E. Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparan // Toxins. – 2015. – Vo l. 7, – № 4. – Р. 1126–1150. doi: 10.3390/toxins7041126.
  65. National Center for Biotechnology Information. PubChem Compound Database; CID=90684471, https://pubchem.ncbi.nlm.nih.gov/compound/90684471 (accessed Dec 5, 2016).
  66. National Center for Biotechnology Information. PubChem Compound Database; CID=6324633, https://pubchem.ncbi.nlm.nih.gov/compound/6324633 (accessed Dec 5, 2016).
  67. Kim K.H., Sung H.J., Lee W.R., An H.J., Kim J.Y., Pak S.C., Han S.M., Park K.K. Effects of melittin treatment in cholangitis and biliary fibrosis in a model of xenobiotic-induced cholestasis in mice // – Toxins. – 2015. – Vo l. 7, – № 9. – Р. 3372–3387. doi: 10.3390/toxins7093372.
  68. Li D., Lee Y., Kim W., Lee K., Bae H., Kim S.K. Analgesic effects of bee venom derived phospholipase A2 in a mouse model of oxaliplatin-induced neuropathic pain // Toxins. – 2015. – Vo l. 7, – № 7. – Р. 2422–2434. https:// doi.org/10.3390/toxins7072422.
  69. Hyun J.A., Kyung H.K., Lee W.R., Kim J.Y., Lee S.J., Pak S.K., Han S.M., Park K.K. Anti-fibrotic effect of natural toxin bee venom on animal model of unilateral ureteral obstruction // Toxins. – 2015. – Vo l. 7, – №6. – Р. 1917–1928. doi: 10.3390/toxins7061917.
  70. Lee W.R., Pak S.C., Park K.K. The protective effect of bee venom on fibrosis causing inflammatory diseases // Toxins. – 2015. – Vo l. 7, – № 11. – Р. 4758–4772. doi: 10.3390/toxins7114758.
  71. Silva J., Monge-Fuentes V., Gomes F., Lopes K., Anjos L., Campos G., Arenas C., Biolchi A., Gonçalves J., Galante P., Campos L., Mortari M. Pharmacological alternatives for the treatment of neurodegenerative disorders: Wasp and bee venoms and their components as new neuroactive tools // Toxins. – 2015. – Vo l. 7, – № 8. – Р. 3179–3209. doi: 10.3390/toxins7083179.
  72. Hwang D.S., Kim S.K., Bae H. Therapeutic effects of bee venom on immunological and neurological diseases // Toxins. – 2015. – Vo l. 7, – № 7. – Р. 2413–2421. https://doi.org/10.3390/toxins7072413.
  73. Lee J.A., Kim Y.M., Hyun P.M., Jeon J.W., Park J.K., Suh G.H., Jung B.G., Lee B.J. Honeybee (Apis mellifera) venom reinforces viral clearance during the early stage of infection with porcine reproductive and respiratory syndrome virus through the up-regulation of th1-specific immune responses // Toxins. – 2015. – Vo l. 7, – № 5. – Р. 1837–1853. doi: 10.3390/toxins7051837.
  74. Артемов Н.М., Зевеке А.В. Физиологический анализ гипотензивного действия пчелиного яда // Уч. зап. Горьк. ун-та. Сер. биол. Горький. – 1967. – №82. – C. 25–47.
  75. Корнева Н.В. Физиологический анализ рефлекторного действия некоторых животных ядов. Автореф. дисс. на соиск. уч. степ. канд. биол. наук, Горький, 1970, 20 с.
  76. Крылов В.Н. Физиологическое обоснование применения пчелиного яда в апитерапии // Вестник Нижегородского университета им. Н.И. Лобачевского Серия Биология. – 1999. №1. – С. 66–71.
  77. Сабурцев С.A., Бобылева O.A., Крылов В.Н. Анализ гипертензивного эффекта пчелиного яда // Вестник Нижегородского гос. университета. 1995. С. 12–14.
  78. Крылов В.Н. Пчелиный яд. Свойства, получение, применение. – Н. Новгород: Изд. Нижегородского университета, 1995. – 134 с.
  79. Лебедев В.И., Докукин Ю.В., Прокофьева Л.В. Состояние и перспективы отечественного пчеловодства // Пчеловодство. – 2015. – №5. – С. 3–5.
  80. Ишмуратов Г.Ю., Выдрина В.А., Насибуллина Г.В., Толстиков Г.А. Синтез 9-оксо-2Е-деценовой кислоты – многофункционального феромона медоносных пчел Apis melliferaL // Вестник Башкирского университета. – 2008. – Vo l. 13, – № 3.
  81. Ebert G.W. A Two-Step Synthesis of the “Queen Substance” of the Honey Bee // Synthetic communications. – 1991. – Vo l. 21, – № 14. – Р. 1527–1531. https://doi.org/10.1080/00397919108016427.
  82. Ishmuratov G.Yu., Yakovleva M.P., Botsman L.P., Ishmuratova N.M., Muslukhov R.R., Khambalova G.V., Tolstikov G.A. Synthesis of a multifunctional pheromone of the honeybee Apis mellifera via condensation of 7-oxooctanal with malonic acid // Chemistry of natural compounds. – 2003. – Vol. 39, – № 1. – Р. 28–30. DOI https:// doi.org/10.1023/A:1024172327822.
  83. Heppell J.T., Boon W.C., Al-Rawi J.M.A. Synthesis of (E)-10-hydroxy-2-decenoic acid ethyl ester via a one-pot tandem oxidation-Wittig process // Organic Communications. – 2018. – Vo l. 11, – № 3.
  84. Pirk C. W. W. Honeybee Evolution: Royal Jelly Proteins Help Queen Larvae to Stay on Top // Current Biology. – 2018. – Vo l. 28, – №8. – Р. 350–351.
  85. Tian W., Li M., Guo H., Peng W., Xue X., Hu Y., Chen Z. Architecture of the native major royal jelly protein 1 oligomer // Nature communications. – 2018. – Vo l. 9, – № 1. – Р. 3373.
  86. Jayakumaran R.A., Ramanathana K.G., Nair A.J., Sugunan V.S. Review on Royal Jelly proteins and peptides // Journal of functional foods. – 2018. – Vol. 44, – P. 255–264.

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