CURRENT VIEW ON TONSILLOGENIC DISEASES - IGA NEPHROPATHY, HEMORRHAGIC VASCULITIS AND THE EFFECT OF TONSILLECTOMY ON THEIR COURSE


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Abstract

IgA nephropathy and hemorrhagic vasculitis are IgA-mediated metatonsillar diseases. We analyzed the literature covering their pathogenesis, association with chronic tonsillitis (CT) and the influence of tonsillectomy (TE) on their course. It has been shown that in IgA nephropathy TE is associated with a higher rate of clinical remission and inhibition of the progression of renal failure as a result of a decrease in the mucosal production of abnormally galactosylated IgA1 molecules. This thesis is confirmed by highly evidenced studies among the Asian population and single comparative studies for the Caucasian race. Accordingly, Asian, in particular Japanese, recommendations include TE as a treatment option for this group of patients.

In hemorrhagic vasculitis, the effectiveness of TE has been confirmed only for clinical course with kidney damage. For other forms, symptomatic treatment is preferable, and TE is indicated when there is a proven association between exacerbations of CT and deterioration of kidney disease. Further research in this area is required, expanding the sample of patients with IgA-mediated diseases and possibly assessing the influence of genetic characteristics on treatment outcome.

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About the authors

Tatyana S. Zaytseva

ENT Center LLC. Head and Neck Surgery.

Email: zaitzevat@gmail.com
ORCID iD: 0009-0000-2818-4006
SPIN-code: 4945-9349

ENT doctor, ENT Center LLC. Head and Neck Surgery. Russia, 119034, Moscow, ul. Novosushchevskaya, d. 21

Russian Federation, Russia, 119034, Moscow, ul. Novosushchevskaya, d. 21

Anna A. Nesterova

ENT Center LLC. Head and Neck Surgery.

Email: annamedical@gmail.com
ORCID iD: 0000-0002-2637-855X
SPIN-code: 1942-5352

Cand. Med. Sci., ENT doctor, Deputy for medical and scientific part

Russian Federation, Russia, 119034, Moscow, ul. Novosushchevskaya, d. 21

Klimentina I Nesterova

Omsk State Medical University, Russia

Email: klnesterova@gmail.com
ORCID iD: 0000-0002-9793-7179
SPIN-code: 9253-9964
Scopus Author ID: 8555826800
ResearcherId: KCY-6245-2024

D. Med. Sci., Professor of the Department of ENT

Russian Federation, Russia, 644099 Omsk, st. Lenina, 12

Ruben G. Mirakyan

Author for correspondence.
Email: rgmirakyan@lormedcentr.ru
ORCID iD: 0009-0000-1132-1967

Anastasia A. Lesnykh

Omsk State Medical University

Email: lady.lesnyh2018@yandex.ru

6th year student of the Faculty of Medicine

Russian Federation, Russia, 644099 Omsk, st. Lenina, 12

Vladislav O. Eremchenko

, Omsk State Medical University, Russia,

Email: vladik_kz_99@mail.ru
ORCID iD: 0009-0004-0897-2362

clinical resident of the Department of ENT

Russian Federation, 644099 Omsk, st. Lenina, 12

Anastasia R. Volosnikova

of the KMHC MZOO LLC

Email: volosomsk@mail.ru

bacteriologist, head of the microbiological laboratory 

Russian Federation, 644007 Omsk, st. Bulatova, 105

Maria V. Ermolaeva

KMHC MZOO LLC

Email: ermolaevamava@yandex.ru

bacteriologist

Russian Federation, 644007 Omsk, st. Bulatova, 105

Valeria V. Terre

KMHC MZOO LLC

Email: v.terre@clinica-omsk.ru

bacteriologist 

Russian Federation, 644007 Omsk, st. Bulatova, 105

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