The role of apoptosis-regulating ligand-receptor Fas and TNF-a systems ratios in the ischemic stroke clinical manifestations formation


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Abstract

Material and methods. The content of sFas, sFasL, TNF-a, sTNF-R1, IL-6 was detected in the blood on days 1, 7, and 21 by ELISA in 155 patients with LMBA or RMBA IS, as well as Fas-positive lymphocytes by flow cytofluorometry. Neurological suffering was assessed using the NIHSS. Results. A significant increase in blood concentrations of sFasL, sFas and TNF-a was shown compared to the control. Conclusion. In stroke manifestation the role of the Fas system is associated with inflammatory response; at the end of the acute period, with the dominance of adaptive mechanisms and processes of neuroplasticity.

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About the authors

Svetlana P. Sergeeva

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: svetlanapalna@mail.ru
PhD in Medicine, associate professor of the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

Alexey A. Savin

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: a9165383509@gmail.com
Dr. med. habil., professor of the Department of nervous diseases 127473, Moscow, 20/1 Delegatskaya Str

Petr F. Litvitsky

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: litvicki@mma.ru
Dr. med. habil., professor, corresponding member of RAS, head of the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

Leonid A. Savin

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: lasavin@0mail.ru
PhD in Medicine, assistant at the Department of nervous diseases 127473, Moscow, 20/1 Delegatskaya Str

Zaripat Sh. Manasova

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: zmanasova@yandex.ru
PhD in Medicine, associate professor of the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

Dzhennet D. Dzhumagulova

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: butri78@mail.ru
student 119991, Moscow, 8/2 Trubetskaya Str

Ilya D. Breslavich

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: br_i@inbox.ru
assistant at the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

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