The role of apoptosis-regulating ligand-receptor Fas and TNF-a systems ratios in the ischemic stroke clinical manifestations formation


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Material and methods. The content of sFas, sFasL, TNF-a, sTNF-R1, IL-6 was detected in the blood on days 1, 7, and 21 by ELISA in 155 patients with LMBA or RMBA IS, as well as Fas-positive lymphocytes by flow cytofluorometry. Neurological suffering was assessed using the NIHSS. Results. A significant increase in blood concentrations of sFasL, sFas and TNF-a was shown compared to the control. Conclusion. In stroke manifestation the role of the Fas system is associated with inflammatory response; at the end of the acute period, with the dominance of adaptive mechanisms and processes of neuroplasticity.

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作者简介

Svetlana Sergeeva

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: svetlanapalna@mail.ru
PhD in Medicine, associate professor of the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

Alexey Savin

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: a9165383509@gmail.com
Dr. med. habil., professor of the Department of nervous diseases 127473, Moscow, 20/1 Delegatskaya Str

Petr Litvitsky

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: litvicki@mma.ru
Dr. med. habil., professor, corresponding member of RAS, head of the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

Leonid Savin

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: lasavin@0mail.ru
PhD in Medicine, assistant at the Department of nervous diseases 127473, Moscow, 20/1 Delegatskaya Str

Zaripat Manasova

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: zmanasova@yandex.ru
PhD in Medicine, associate professor of the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

Dzhennet Dzhumagulova

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: butri78@mail.ru
student 119991, Moscow, 8/2 Trubetskaya Str

Ilya Breslavich

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: br_i@inbox.ru
assistant at the Department of pathophysiology 119991, Moscow, 8/2 Trubetskaya Str

参考

  1. Суслина З.А., Пирадов М.А., Домашенко М.А. Инсульт: оценка проблемы (15 лет спустя). Журнал неврологии и психиатрии им. С.С. Корсакова. 2014; 114(11): 5-13. EDN: TGMHXR
  2. Федин А.И., Бадалян К.Р. Обзор клинических рекомендаций лечения и профилактики ишемического инсульта. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019; 1 19(8-2): 95-100. https://dx.doi.org/10.17116/jnevro201911908295. EDN: UIDYQS
  3. Radak D., Katsiki N., Resanovic I. et al. Apoptosis and acute brain ischemia in ischemic stroke. Curr Vasc Pharmacol. 2017; 15(2): 115-22. https://dx.doi.org/10.2174/1570161115666161104095522.
  4. Zhang Y., Cao Y., Liu C. Autophagy and ischemic stroke. In: Le W. (eds) Autophagy: Biology and diseases. Advances in Experimental Medicine and Biology. Springer Singapore. 2020; 1207: 111-34. https://dx.doi.org/10.1007/978-981-15-4272-5_7.
  5. Lossi L. The concept of intrinsic versus extrinsic apoptosis. Biochem J. 2022; 479(3): 357-84. https://dx.doi.org/10.1042/BCJ20210854.
  6. Akamatsu Y., Hanafy K.A. Cell death and recovery in traumatic brain injury. Neurotherapeutics. 2020; 17(2): 446-56. https://dx.doi.org/10.1007/s13311-020-00840-7.
  7. Bhattacharya A., Ashouri R., Fangman M. et al. Soluble receptors affecting stroke outcomes: Potential biomarkers and therapeutic tools. Int J Mol Sci. 2021; 22(3): 1108. https://dx.doi.org/10.3390/ijms22031108.
  8. Lorente L., Martin M.M., Perez-Cejas A. et al. High serum soluble Fas ligand levels in non-survivor traumatic brain injury patients. Neurocrit Care. 2021; 35(1): 249-54. https://dx.doi.org/10.1007/s12028-020-01158-0.
  9. Montellano F.A., Ungethum K., Ramiro L. et al. Role of blood-based biomarkers in ischemic stroke prognosis. Stroke. 2021; 52(2): 543-51. https://dx.doi.org/10.1161/STROKEAHA.120.029232.
  10. Kim S., Kim N., Lee J. et al. Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement. Sci Adv. 2020; 6(17): eaaz9691. https://dx.doi.org/10.1126/sciadv.aaz9691.
  11. Shen Y., Song Z., Lu X. et al. Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions. Nat Commun. 2019; 10(1): 2924. https://dx.doi.org/10.1038/s41467-019-10889-4.
  12. Seyrek K., Lavrik I.N. Modulation of CD95-mediated signaling by post-translational modifications: Towards understanding CD95 signaling networks. Apoptosis. 2019; 24(5-6): 385-94. https://dx.doi.org/10.1007/s10495-019-01540-0.
  13. Guegan J.P., Ginestier C., Charafe-Jauffret E. et al. CD95/Fas and metastatic disease: What does not kill you makes you stronger. Semin Cancer Biol. 2020; 60: 121-31. https://dx.doi.org/10.1016/j.semcancer.2019.06.004.
  14. Northington F.J., Zelaya M.E., O'Riordan D.P. et al. Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as «continuum» phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain. Neuroscience.2007; 149(4): 822-33. https://dx.doi.org/10.1016/j.neuroscience.2007.06.060.
  15. Leigh R., Knutsson L., Zhou J., van Zijl P.C. Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke. J Cereb Blood Flow Metab. 2018; 38(9): 1500-16. https://dx.doi.org/10.1177/0271678X17700913.
  16. DeLong J.H., Ohashi S.N., O'Connor K.C., Sansing L.H. Inflammatory responses after ischemic stroke. Semin Immunopathol. 2022; 44(5): 625-48. https://dx.doi.org/10.1007/s00281-022-00943-7.
  17. Tanaka T., Narazaki M., Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014; 6(10): a016295. https://dx.doi.org/10.1101/cshperspect.a016295.

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