Influence of secondary diabetic respiratory muscle myopathy at external respiratory function in type 2 diabetes mellitus patients
- Authors: Ivanov K.M.1, Kunarbaeva A.K.1, Miroshnichenko I.V.1, Miroshnichenko A.I.2
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Affiliations:
- Orenburg State Medical University of the Ministry of Healthcare of Russia
- Clinic of Industrial Medicine LLC
- Issue: Vol 8, No 10 (2022)
- Pages: 72-78
- Section: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/276840
- DOI: https://doi.org/10.18565/therapy.2022.10.72-78
- ID: 276840
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Abstract
Diabetes mellitus (DM) has an adverse effect on the skeletal muscle system. The aim of the study is to assess changes in external respiration function in patients with type 2 diabetes having secondary diabetic myopathy. Material and methods. We examined 47 patients with type 2 diabetes (29 patients with a disease duration of less than 5 years and 18 patients with a disease duration of more than 5 years), in whom the parameters of lung ventilation and the strength of the respiratory muscles were assessed in terms of maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP). In accordance with the revealed values of changes in the strength of the respiratory muscles, patients with DM were divided into 2 subgroups: 1st 25 patients with established weakness of the inspiratory muscles; 2nd 22 patients with preserved inspiratory muscle strength. Results. In patients with DM, MIP median was 28,6% lower than in patients without carbohydrate metabolism disorders. MIP median in patients with more than 5 years of DM was 6,3% lower than the expected value, which indicated weakness of the inspiratory muscles coming with such a duration of the disease. Patients with DM had lower indicators of lung ventilation than in the comparison group. Also, lower spirometry values were observed in study participants with a duration of diabetes over 5 years relatively to patients with a shorter history of the disease and in patients with diagnosed inspiratory muscle weakness comparatively with individuals who had preserved the strength of these muscles. Performed correlation analysis revealed statistically significant positive correlations between spirometry data and MIP and MEP in the group of diabetic patients. Conclusion. Long lasting course of type 2 diabetes (more than 5 years) leads to the development of secondary diabetic myopathy, characterized by the development of inspiratory muscle weakness. With the duration of type 2 diabetes over 5 years and the occurrence of secondary diabetic myopathy, a decrease of pulmonary ventilation parameters takes place.
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About the authors
Konstantin M. Ivanov
Orenburg State Medical University of the Ministry of Healthcare of RussiaDr. med. habil., professor, head of the Department of propaedeutics of internal diseases
Adel K. Kunarbaeva
Orenburg State Medical University of the Ministry of Healthcare of Russia
Email: kunarbaeva.adel@yandex.ru
assistant of the Department of propaedeutics of internal diseases
Igor V. Miroshnichenko
Orenburg State Medical University of the Ministry of Healthcare of Russia
Email: k_normphys@orgma.ru
Dr. med. habil., professor, head of the Department of normal physiology
Anastasia I. Miroshnichenko
Clinic of Industrial Medicine LLC
Email: miroshni4enko.nast@yandex.ru
therapist
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