Cellular and molecular mechanisms of COVID-19 pathogenesis, systemic dysregulation and therapy targets

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Abstract

Accumulated clinical experience shows that the pathogenesis of respiratory distress syndrome in patients with COVID-19 has a huge range of manifestations. The key component of this pathogenesis is endothelial dysfunction and dysregulation of multiple molecular and cellular control systems for blood coagulation, microhemodynamics, diffusion, hyperinflammation, and immunothrombosis, which is referred to in this review as «storm-2». From the viewpoint of pathophysiology, COVID-19 is a dissonance of a large number of cellular and molecular components, functional details that make up homeostasis, which, under conditions of viral aggression, work as a sequential destruction system. The processes of biochemical and cellular disorganization caused by the SARS-CoV-2 coronavirus reflect the key links in the pathogenesis of a new coronavirus infection. Identification of these links determines the search for effective approaches to the treatment of COVID-19 using both traditional and innovative curative facilities.

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About the authors

Oleg A. Gomazkov

V.N. Orekhovich Research Institute of Biomedical Chemistry

Email: oleg-gomazkov@yandex.ru
Doctor of biological sciences, professor, chief researcher

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