Diabetic polyneuropathy. Briefly about the main
- Authors: Meleshkevich T.A.1, Luchina Y.I.2, Shevchenko M.Y.2
-
Affiliations:
- N.A. Semashko Central Clinical Hospital № 2 (JSC "Russian Railways”)
- N.A. Semashko Central Clinical Hospital № 2 (JSC "Russian Railways")
- Issue: No 4 (2016)
- Pages: 18-22
- Section: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/277462
- ID: 277462
Cite item
Open Access
Access granted
Abstract
The defeat of the peripheral nervous system (polyneuropathy) is among the most frequent complications of diabetes mellitus (DM) and can be combined with other microvascular complications such as retinopathy and nephropathy, which indicates the general mechanisms of the pathogenesis of this pathology. The incidence of neuropathy depend not only on the duration of diabetes, but also on the effectiveness of its treatment. Diabetic polyneuropathy (DPN) is one of the major risk factors for foot ulcers, osteoarthropathy, non-traumatic amputations, so its diagnosis is extremely important. Distal symmetrical localization is typical for DPN, this is what distinguishes it from other kinds of neuropathy. Recommended diagnostic tests are fairly simple to use and can be easily applied in clinical practice. Today, armed with a doctor there are unique pathogenic agents (α-lipoic acid, vitamin B complex), which have antioxidant and metabolic effects that would greatly improve the prognosis of patients with DPN.
Full Text
About the authors
Tatiana Antonovna Meleshkevich
N.A. Semashko Central Clinical Hospital № 2 (JSC "Russian Railways”)PhD, Head of Department of Endocrinology
Yevgeniya Igorevna Luchina
N.A. Semashko Central Clinical Hospital № 2 (JSC "Russian Railways")endocrinologist, Department of Endocrinology
Marina Yevgenievna Shevchenko
N.A. Semashko Central Clinical Hospital № 2 (JSC "Russian Railways")endocrinologist, Department of Endocrinology
References
- Kempler P., Varkonyi T. Нейропатии в клинической практике. 2013 г.
- Анциферов М.Б., Волковой А.К. Диагностика и лечение диабетической дистальной полинейропатии у больных сахарным диабетом в амбулаторной практике. РМЖ. 2008; 16(15):994-9. [Antsiferov M.B., Volkovoy A.K. Diagnosis and treatment of diabetic distal polyneuropathy diabetic patients in outpatient practice. Russian Medical Journal. 2008;16(15):994-9 (in Russian)]
- Недосугова Л.В. Диабетическая полинейропатия и окислительный стресс. Патогенез, диагностика, лечение. Учебное пособие ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова». Москва, 2015. [Nedosugova L.V. Diabetic neuropathy and oxidative stress Pathogenesis, diagnosis, treatment. Textbook of I.M. Sechenov First MGMU. Moscow, 2015 (in Russian)]
- Практические рекомендации по лечению и профилактике диабетической стопы, основанные на международном консенсусе по диабетической стопе под ред. проф. И.В. Гурьевой, 2012 г. [Practical recommendations for the treatment and prevention of diabetic foot based on an international consensus on the diabetic foot. Edited by prof I.V. Gurieva, 2012 (in Russian)]
- Галстян Г.Р. Диабетическая нейропатия: классификация, диагностика и лечение. Международный эндокринологический журнал. 2006;3(5). [Galstyan G.R. Diabetic nephropathy: classification, diagnosis and treatment International Journal of Endocrinology. 2006;3(5) (in Russian)]
- Papanas N., Ziegler D. Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy. Journal of Diabetes Investigation. 2015;6(4):381-9.
- Осложнения сахарного диабета: патофизиология и варианты патогенетического лечения. Международная рабочая встреча экспертов 09.2008, Рим, Италия. Под ред. П.Д. Тонелли, П. Кемплер. [Complications of diabetes: pathophysiology and treatment of pathogenic variants International working meeting of experts 09.2008, Rome, Italy. Edited by P.D. Tonelli, P. Kempler (in Russian)]
- Ziegler D., Hanefeld M., Hasche K.J., Lobisch M., Schutte K., Kerum G., Malessa R., the ALADIN III Study Group: Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid. Diabetes Care. 1999;22:1296-301.
- Ametov A.S., Barinov A., Dyck P., Hermann R., Kozlova N., Litchy W., Low P., Nehrdich D., Movosadova M., O'Brien P.C., Rejanovic M., Samigullin R., Schuette K., Strokov I., Tritchler H., Wessel K., Yakhno N., Ziegler D., the SYDNEY Trial Authors for the SYDNEY Trial Study Group. The sensory symptoms of diabetic polyneuropathy are improved with alphalipoic acid. Diabetes Care. 2003;26:770-6.
- Ziegler D., Ametov A., Barinov A., Dyck P.J., Gurieva I., Low P.A., Munzel U., Novosadova M., Raz I., Wainstein J., Maus J., Samigullin R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy. The SYDNEY II. Trial. Diabetes Care. 2006; 29:2365-70.
- Ziegler D., Nowak H., Kempler P., Vargha P., Low A. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipolic acid: a meta-analysis. Diabet Med. 2004;21:114-21.
Supplementary files
