Indicators of immunogenicity of influenza vaccine in HIV-infected patients seronegative to influenza virus


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Abstract

The immune response to standard scheme of seasonal vaccination against influenza was evaluated in HIV-infected patients without specific antibodies to influenza virus before vaccination. Titers of hemagglutinating antibodies to antigens of influenza virus A (H1N1), A (H3N2) and B were detected in standard agglutination inhibition test: before vaccination (day 0) and after it (on 21th and 150th days). Coefficient of seroconversion varied from 1.6to 2.3, seroconversion rate varied from 0to 25%); seroprotection rate - from 67% to A (H1N1) to 100% to A (H3N2) and B. Titer of antibodies detected on day 21 retained in all cases up to day 150 after vaccination. The minimal protective level of antibodies (1/40) was detected in the majority of vaccinated persons, including the at least fourfold increase of it in patients with CD4-cells level more than 350/pl.

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About the authors

Rafael’ G. Yapparov

Republican center for prevention and control of AIDS and infectious diseases

Email: rafdok@yandex.ru
chief doctor, infectiologist

Dmitry A. Lioznov

Research Institute of Influenza; Pavlov First State Medical University

Email: dlioznov@yandex.ru
MD, deputy director for science; head of the Department Of infectious diseases and epidemiology

Elena Yu. Karnaukhova

Pavlov First State Medical University

Email: elena_yk@list.ru
PhD, assistant professor of the Department of infectious diseases and epidemiology

Timofey L. Galankin

Pavlov First State Medical University

Email: galankint@gmail.com
PhD, head of the laboratory of pharmacoepidemiology and pharmacocinetics

Tamara V. Antonova

Pavlov First State Medical University

Email: antonovatv28@yandex.ru
MD, professor, professor of the Department of knfectious diseases and epidemiology

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