Indicators of immunogenicity of influenza vaccine in HIV-infected patients seronegative to influenza virus


Дәйексөз келтіру

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Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The immune response to standard scheme of seasonal vaccination against influenza was evaluated in HIV-infected patients without specific antibodies to influenza virus before vaccination. Titers of hemagglutinating antibodies to antigens of influenza virus A (H1N1), A (H3N2) and B were detected in standard agglutination inhibition test: before vaccination (day 0) and after it (on 21th and 150th days). Coefficient of seroconversion varied from 1.6to 2.3, seroconversion rate varied from 0to 25%); seroprotection rate - from 67% to A (H1N1) to 100% to A (H3N2) and B. Titer of antibodies detected on day 21 retained in all cases up to day 150 after vaccination. The minimal protective level of antibodies (1/40) was detected in the majority of vaccinated persons, including the at least fourfold increase of it in patients with CD4-cells level more than 350/pl.

Негізгі сөздер

Толық мәтін

Рұқсат жабық

Авторлар туралы

Rafael’ Yapparov

Republican center for prevention and control of AIDS and infectious diseases

Email: rafdok@yandex.ru
chief doctor, infectiologist

Dmitry Lioznov

Research Institute of Influenza; Pavlov First State Medical University

Email: dlioznov@yandex.ru
MD, deputy director for science; head of the Department Of infectious diseases and epidemiology

Elena Karnaukhova

Pavlov First State Medical University

Email: elena_yk@list.ru
PhD, assistant professor of the Department of infectious diseases and epidemiology

Timofey Galankin

Pavlov First State Medical University

Email: galankint@gmail.com
PhD, head of the laboratory of pharmacoepidemiology and pharmacocinetics

Tamara Antonova

Pavlov First State Medical University

Email: antonovatv28@yandex.ru
MD, professor, professor of the Department of knfectious diseases and epidemiology

Әдебиет тізімі

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