Peculiarities of changes in respiratory muscles strength and in lipid peroxidation processes in patients with type 2 diabetes mellitus

The aim of the study was to identify the features of changes in the processes of lipid peroxidation (LPO), antioxidant system condition and to fix their correlation with indexes of the strength of the respiratory muscles in patients with type 2 diabetes mellitus (DM). Material and methods. In 19 patients with type 2 diabetes were assessed: strength of the respiratory muscles - by indexes of the maximal inspiratory pressure and the maximal expiratory pressure at the level of the oral cavity; activity of LPO processes - by determining malondialdehyde (MDA) and diene conjugates in blood serum; activity of the antioxidant system - by changing the activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytic hemolysate. Results. The strength of the inspiratory muscles in patients with DM was lower than in the comparison group by 21,6%. They had an increase in MDA content by 51,3% and a decrease in SOD activity by 17,2% comparatively with patients without carbohydrate metabolism disorders. An average level of positive correlation relationship was found between the indicator of maximum inspiratory pressure and the level of CAT activity (r=0,35; p «0,05). Conclusion. Patients with type 2 diabetes mellitus have reduced strength of the inspiratory respiratory muscles, the state of the prooxidant-antioxidant system in them is characterized by an increase of MDA level and a decrease in SOD activity. A positive correlation was found between the change in the strength of the inspiratory muscles and the activity of CAT in erythrocytic hemolysate.

type 2 diabetes mellitus, strength of respiratory muscles, lipid peroxidation