Chronic brain ischemia as an interdisciplinary problem


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

The article reviews the issues of pathogenesis, clinic, diagnosis and treatment of chronic brain ischemia. Highlights of the development of «small vessel disease», endothelial dysfunction, processes of lipid peroxidation, apoptosis as well as neuroplasticity. The necessity of joint management of patients with chronic cerebral ischemia by neurologists and doctors of other specialties and the appointment of individualized pathogenetic therapy are noted.

全文:

受限制的访问

作者简介

Elena Chukanova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

MD, professor of the Department of of neurology, neurosurgery and medical genetics of the Faculty of medicine

Anna Chukanova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

PhD, associate professor of the Department of of neurology, neurosurgery and medical genetics of the Faculty of medicine

Sona Bagmanyan

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

senior laboratory assistant of the Department of of neurology, neurosurgery and medical genetics of the Faculty of medicine

参考

  1. Дамулин И.В. Дисциркуляторная энцефалопатия в пожилом и старческом возрасте. Дис. д-ра мед. наук. М., 1997.
  2. Гомазков О.А. Нейротрофические и ростовые факторы мозга: регуляторная специфика и терапевтический потенциал. Успехи физиологических наук. 2005: 2: 22-40.
  3. Leppala J.M., Virtamo J., Fogelholm R. et al. Different risk factors for different stroke subtypes: association of blood pressure, cholesterol, and antioxidants. Stroke. 1999; 30(12): 2535-40. doi: 10.1161/01.str.30.12.2535.
  4. Goldstein L.B., Adams R., Becker K. et al. Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke. 2001; 32(1): 280-99. doi: 10.1161/01.str.32.1.280.
  5. Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev. 2005; 57(2): 173-85. doi: 10.1124/pr.57.2.4.
  6. Ганнушкина И.В. Иммунологические аспекты травмы и сосудистых поражений головного мозга. М.: Медицина, 1974: 199 с.
  7. Гусев Е.И., Скворцова В.И. Ишемия головного мозга. М: Медицина, 2001: 328 с. [Gusev E.I., Skvortsova V.I. Ischemia of the brain. Moscow: Meditsina = Medicine. 2001: 328 pp. (In Russ.)]. ISBN: 5-225-04642-8
  8. Yang Y., Rosenberg G.A. Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke. 2011; 42(11): 3323-28. doi: 10.1161/STROKEAHA.110.608257.
  9. Petersen M.A., Ryu J.K., Akassoglou K. Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics. Nat Rev Neurosci. 2018; 19(5): 283-301. doi: 10.1038/nrn.2018.13.
  10. Wardlaw J.M., Doubal F.N., Valdes-Hernandez M. et al. Blood-brain barrier permeability and long-term clinical and imaging outcomes in cerebral small vessel disease. Stroke. 2013; 44(2): 525-27. doi: 10.1161/STROKEAHA.112.669994.
  11. Li Y., Li M., Zuo L. et al. Compromised blood-brain barrier integrity is associated with total magnetic resonance imaging burden of cerebral small vessel disease. Front Neurol. 2018; 9: 221. doi: 10.3389/fneur.2018.00221.
  12. Raja R., Rosenberg G.A., Caprihan A. MRI measurements of blood-brain barrier function in dementia: A review of recent studies. Neuropharmacology. 2018; 134(Pt B): 259-71. doi: 10.1016/j.neuropharm.2017.10.034.
  13. Zhang C.E., Wong S.M., Uiterwijk R. et al. Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging. Brain Imaging Behav. 2019; 13(2): 389-95. doi: 10.1007/s11682-018-9855-7.
  14. Vinters H.V., Zarow C., Borys E. et al. Review: Vascular dementia: clinicopathologic and genetic considerations. Neuropathol Appl Neurobiol. 2018; 44(3): 247-66. doi: 10.1111/nan.12472.
  15. Ostergaard L., Engedal T.S., Moreton F. et al. Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline. J. Cereb Blood Flow Metab. 2016; 36(2): 302-25. doi: 10.1177/0271678X15606723.
  16. Wardlaw J.M., Chappell F.M., Valdes Hernandez M.D.C. et al. White matter hyperintensity reduction and outcomes after minor stroke. Neurology. 2017; 89(10): 1003-10. doi: 10.1212/WNL.0000000000004328.
  17. van Leijsen E.M.C., van Uden I.W.M., Ghafoorian M. et al. Nonlinear temporal dynamics of cerebral small vessel disease: The RUN DMC study. Neurology. 2017; 89(15): 1569-77. doi: 10.1212/WNL.0000000000004490.
  18. Wolfe L.S. Eicosanoids: prostaglandins, thromboxanes, leukotrienes, and other derivatives of carbon-20 unsaturated fatty acids. J. Neurochem. 1982; 38(1): 1-14. doi: 10.1111/j.1471-4159.1982.tb10847.x.
  19. Packer L.L., Packer L., Prilipko Y., Cyirsten Y. Free radicals in the brain aging, neurological and mental disorders. Berlin Springer-Verlad. 1992; 120.
  20. Zhang F., White J.G., Iadecola C. Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J. Cereb Blood Flow Metab. 1994; 14(2): 217-26. doi: 10.1038/ jcbfm.1994.28.
  21. Chen P., Goldberg D.E., Kolb B. et al. Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc Natl Acad Sci U. S. A. 2002; 99(13): 9031-36. doi: 10.1073/pnas.132076299.
  22. Wang Y., Chang C.F., Morales M. et al. Bone morphogenetic protein-6 reduces ischemia-induced brain damage in rats. Stroke. 2001; 32(9): 2170-78. doi: 10.1161/hs0901.095650.
  23. Alison M.R., Sarraf C.E. Apoptosis as a gene-directed program of cell death. In: Principles of Medical Biology Editor(s): E. Edward Bittar, Neville Bittar. Vol. 13. 1998; 1-55. doi: 10.1016/S1569-2582(98)80003-2.
  24. Барышников А.Ю., Шишкин Ю.В. Иммунологические проблемы апоптоза. М., 2002; 318 с.
  25. Mattson M.P. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol. 2000; 1(2): 120-29. doi: 10.1038/35040009.
  26. Binder D.K., Croll S.D., Gall C.M., Scharfman H.E. BDNF and epilepsy: too much of a good thing? Trends Neurosci. 2001; 24(1): 47-53. doi: 10.1016/s0166-2236(00)01682-9.
  27. Гомазков О.А. Нейротрофическая регуляция и стволовые клетки мозга. М., 2006. 330 с.
  28. Muresanu D.F. Neuroprotection and neuroplasticity - a holistic approach and future perspectives. J. Neurol Sci. 2007; 257(1-2): 38-43. doi: 10.1016/j.jns.2007.01.041.
  29. Marrone D.F., LeBoutillier J.C., Petit T.L. Changes in synaptic ultrastructure during reactive synaptogenesis in the rat dentate gyrus. Brain Res. 2004; 1005(1-2): 124-36. doi: 10.1016/j.brainres.2004.01.041.
  30. Боголепов Н.Н., Семченко В.В., Степанов С.С. Закономерности реализации механизмов синаптогенеза в коре большого мозга взрослых крыс после кратковременной тотальной остановки системного кровотока. Сборник статей. Структурнофункциональные и нейрохимические закономерности асимметрии и пластичности мозга. М., 2005; с. 51-54.
  31. Manto M., Oulad ben Taib N., Luft A.R. Modulation of excitability as an early change leading to structural adaptation in the motor cortex. J. Neurosci Res. 2006; 83(2): 177-80. doi: 10.1002/jnr.20733.
  32. Семченко В.В., Степанов С.С., Боголепов Н.Н. Синаптическая пластичность головного мозга. О.: Омская областная типография, 2008; 408 с.
  33. Боголепова А.Н., Чуканова Е.И. Проблема нейропластичности в неврологии. Журнал неврологии и психиатрии им. C.C. Корсакова. 2010; 8: 72-75.
  34. Захаров В.В. Ковтун А.Ю. Диагностика сосудистых когнитивных нарушений. Методические рекомендации. М., 2011; 16 с.
  35. Левин О.С. Дисциркуляторная энцефалопатия. Методическое пособие. М., 2010; 8 с.
  36. Чуканова Е.И. Дисциркуляторная энцефалопатия (клиника, диагностика, лечение) Дис. д-ра мед. наук. 2004.
  37. Yusuf S., Diener H.C., Sacco R.L. et al. PRoFESS Study Group. Telmisartan to prevent recurrent stroke and cardiovascular events. N. Engl J. Med. 2008; 359(12): 1225-37. doi: 10.1056/NEJMoa0804593.

补充文件

附件文件
动作
1. JATS XML
下载
##common.cookie##