THICKNESS OF THE INTIMA-MEDIA COMPLEX OF CAROTID ARTERIES IN PATIENTS WITH EXTRASKELETINAL MANIFESTATIONS OF SPONDYLOARTHRITIS


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The presence of uveitis is one of the risk factors for cardiovascular pathology development in patients with spondyloarthritis (SpA). The aim of the study was to compare the intima-media complex thickness (IMT) of common carotid artery in SpA patients with and without uveitis. Material and methods. The study included 69 patients with SpA meeting ASIS axial spondyloarthritis criteria (2009), including 48 persons (69,6%) with ankylosing spondylitis (AS), 6 (8,7%) with undifferentiated SpA, 15 (21,7%) - with psoriatic arthritis. 30 (43,5%) patients were monitored by ophthalmologist for uveitis; the duration of uveitis was 10.5 [8; 14,5] years. At the time of inclusion in the study, patients with SpA did not have features of active uveitis. Patients with and without uveitis were comparable in terms of sex, age, duration of the disease, age of onset of the disease, BMI, systolic and diastolic blood pressure levels, blood lipid spectrum parameters. Results. The average IMT of the carotid arteries in all patients with SpA was 0.67 [0,57; 0,82] mm; in patients with uveitis, this index was 0,74 [0,58; 0,96] mm, without uveitis - 0,6 [0,55; 0,65] mm (p=0,003). Thickening of the carotid intima-media complex >0,9 mm and the presence of atherosclerotic plaques were found in 13 (43,3%) patients with uveitis and in 7 (17,95%) without uveitis (p=0,041; x2=4,14). Atherosclerotic plaques were found in 7 patients with uveitis and 4 without uveitis. In 10 (76,9%) of 13 patients with uveitis and the presence of carotid intima-media thickening >0,9 mm and/or the presence of atherosclerotic plaques, the side of carotid artery lesions corresponded to the side of uveitis localization. Conclusion. SpA patients with uveitis have increase in IMT of the carotid arteries more often, while the side of the lesion of the carotid arteries mainly corresponds to the side of the localization of uveitis.

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作者简介

Andrey REBROV

V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia

Email: andreyrebrov@yandex.ru
MD, professor, head of the Department of hospital therapy of the Faculty of general medicine, authorized representative of the Russian Scientific Medical Society of Internal Medicine in the Volga Federal District Saratov

Alena APARKINA

V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia

Email: alena437539@yandex.ru
PhD, assistant at the Department of hospital therapy of the Faculty of general medicine Saratov

Kristina GAMAYUNOVA

V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia

Email: k.a.gamayunova@mail.ru
postgraduate student at the Department of hospital therapy of the Faculty of general medicine Saratov

参考

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