NEW POSSIBILITIES OF LOCAL INJECTION THERAPY IN COMPLEX TREATMENT OF SKELETAL AND MUSCULAR PAIN


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Abstract

Local injection therapy (LIT) is a popular treatment method of musculoskeletal pain (MSP) caused by musculoskeletal disorders. LIT is widely used in osteoarthritis (OA) of various localization, as well as in cause of rheumatic periarticular soft tissues pathology (tendinitis, enthesitis, bursitis, etc.). The main medicines for intra-articular and peri-articular administration are glucocorticoids, hyaluronic acid, collagens, biological remedies (polynucleotides, autologous platelet-rich plasma), as well as botulinum type A toxin. The use of these drugs allows to reduce the severity of local pain and dysfunction for a relatively short time or a long time, which seems to be a valuable addition to other methods of complex medicamentous and non-medicamentous MSP therapy. This brief review considers the evidence base for LIT, the advantages and disadvantages of various medicinal remedies, and presents data on their effectiveness and safety.

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About the authors

Vadim A. NESTERENKO

V.A. Nasonova Scientific Research Institute of Rheumatology

Email: swimguy91@mail.ru
PhD, junior researcher of the Laboratory of pain pathophysiology and polymorphism of musculoskeletal diseases Moscow

Andrey E. KARATEEV

V.A. Nasonova Scientific Research Institute of Rheumatology

Email: aekarat@yandex.ru
MD, head of the Department of inflammatory joint pathology Moscow

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