THE EFFECT OF INCREASED HEPCIDIN EXPRESSION ON THE PHARMACOKINETICS OF FERROUS SULFATE IN PATIENTS WITH IRON DEFICIENCY ON THE BACKGROUND OF ANEMIA OF CHRONIC DISEASES
- Authors: Osipyan E.A.1, Makhova A.A.1, Drozdov V.N.1, Shikh E.V.1
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Affiliations:
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University]
- Issue: Vol 8, No 4 (2022)
- Pages: 56-61
- Section: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/289002
- DOI: https://doi.org/10.18565/therapy.2022.4.56-61
- ID: 289002
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Abstract
Currently, the question of how long the level of hepcidin is able to change the metabolism of iron preparations used to compensate for the emerging iron deficiency (ID) is still under consideration. The aim is to study the pharmacokinetics of iron preparations in patients with ID which arised on the background of anemia of chronic diseases (ACD), comparatively with patients with isolated iron deficiency anemia (IIDA). Material and methods. A comparison of pharmacokinetics of iron sulfate in 15 female patients with IIDA and 15 female patients with ID are on the background of ACD was made. Results. The main indicators of iron exchange in the study groups were not significantly different, except for the level of iron-regulating protein hepcidin in patients with ACD + ID comparatively to IIDA patients, 6,1±3,6 versus 15,1±7,3 ng/ml. The area under the curve (AUC) of basal level of iron was 150,96±43,97 pmolxhour/l in patients with IIDA and 112,65±15,88 pmolxhour/l in patients with ACD + ID. After taking 200 mg of iron sulfate AUC increased to 310,18±73,02 pmolxhour/l in patients with IIDA and up to 141,4 pmolxhour/l in patients with ACD + ID. In patients with IIDA, the value of the maximum concentration (Cmax) of iron sulfate in blood (21,2 pmol/l) was achieved more quickly - after 3,1 hours after medicine intake; in patients with ACD and ID Cmax (5,2 pmol/l) was achieved only after 5,6 hours. Conclusion. The obtained data indicate the effect of increased influence of hepcidin at pharmacokinetics of iron preparations in patients with ACD, accompanied by ID.
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About the authors
Elena Ae. Osipyan
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University]
Email: lenaosipyan@gmail.com
postgraduate student of the Department of clinical pharmacology and propaedeutics of internal diseases 119991, Moscow, 8/2 Trubetskaya Str
Anna A. Makhova
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University]Dr. med. habil., associate professor, associate professor of the Department of clinical pharmacology and propaedeutics of internal diseases 119991, Moscow, 8/2 Trubetskaya Str
Vladimir N. Drozdov
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University]Dr. med. habil., professor, professor of the Department of clinical pharmacology and propaedeutics of internal diseases 119991, Moscow, 8/2 Trubetskaya Str
Evgenia V. Shikh
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University]Dr. med. habil., professor, head of the Department of clinical pharmacology and propaedeutics of internal diseases 119991, Moscow, 8/2 Trubetskaya Str
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