The effect of meldonium on the heart rate variability in the complex therapy of patients with chronic heart failure and chronic obstructive pulmonary disease

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Abstract

Chronic heart failure (CHF) in combination with chronic obstructive pulmonary disease (COPD) – common diseases in the clinical practice of a general practitioner.

Purpose: to study the effect of meldonium in the complex therapy on heart rate variability in patients with CHF and COPD.

Material and method. 60 patients were included in a randomized study. The age of the patients was 45–70 years. All the studied patients had CHF II A stage, II–III FC (clinical recommendations of the RSC, SHFS, 2020) and COPD I–III degree of airflow limitation (GOLD 2021 classification) without exacerbation. The patients were divided into 2 groups: the patients of the 1st group (the main group, n=30) with CHF and COPD received meldonium at a dose of 1000 mg/day in addition to the basic therapy, the patients of the 2nd group (the control group, n=30), were treated only basic drugs for CHF and COPD. The patients were followed up for 12 weeks.

Results. After 12 weeks of therapy with the inclusion of meldonium as part of the complex therapy of CHF and COPD, a significant decrease in the incidence of hypersympathicotonia, a decrease in the tension of the regulatory systems of the autonomic nervous system (ANS) was found.

Conclusion. A significant beneficial effect of meldonium as part of complex therapy on the state of the ANS in patients with CHF and COPD was established.

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About the authors

Mikhail E. Statsenko

Volgograd State Medical University of the Ministry of Healthcare of Russia

Author for correspondence.
Email: mestatsenko@rambler.ru
ORCID iD: 0000-0002-3306-0312

MD, professor, vice-rector for scientific work, head of the Department of internal medicine

Russian Federation, Volgograd

Svetlana V. Turkina

Volgograd State Medical University of the Ministry of Healthcare of Russia

Email: turkina.vlg@gmail.com
ORCID iD: 0000-0002-8844-2465

MD, professor of the Department of internal medicine

Russian Federation, Volgograd

Yulia E. Lopushkova

Volgograd State Medical University of the Ministry of Healthcare of Russia

Email: yulija.89@bk.ru
ORCID iD: 0000-0003-2259-2564

assistant at the Department of internal medicine

Russian Federation, Volgograd

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