Damage of nervous system in COVID-19: Neuropsychological syndromes, histological data
- 作者: Mashin V.V.1, Belova L.A.1, Dudikov E.M.1, Slesareva E.V.1, Dolgova D.R.1, Nikishin K.E.1, Lyalchenko Y.A.1
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隶属关系:
- Ulyanovsk State University
- 期: 卷 9, 编号 5 (2023)
- 页面: 32-37
- 栏目: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/569029
- DOI: https://doi.org/10.18565/therapy.2023.5.32–37
- ID: 569029
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详细
Recently, the increasing evidence that COVID-19 can cause severe cognitive and emotional disorders is appearing.
The aim: to estimate the character of neuropsychological and emotional disorders in patients during the period of clinical manifestations of a novel coronavirus infection COVID-19, to perform morphological assessment of the brain condition of deceased patients.
Material and methods. The results of a survey of 112 patients in the period of COVID-19 clinical manifestations are introduced. The mean age of all patients was 61,7±11,5 years. COVID-19 diagnosis was confirmed by instrumental (CT/chest X-ray examination) and laboratory methods (PCR test for SARS-CoV-2 coronavirus RNA presence). Screening testing of cognitive functions (MOCA test) was performed for neuropsychological status assessment. A morphological estimation of the macroscopic parameters and micropreparations of the brain in patients who died from COVID-19 was made. Cerebral cross sections of 20 μm and 5–6 μm thick were stained with hematoxylin-eosin.
Results and conclusion. In the structure of cognitive impairments in COVID-19 patients, optical-spatial disorders occupy the most common place. Morphological studies confirmed the presence of a full-blown plethora and thrombosis of small vessels, mainly in the parieto-occipital regions and vessels of the basal brain surface. The histological picture corresponds to an acute viral lesion of the brain substance with an active reaction of glia, microvessels and significant dystrophic processes both in the bodies of neurons and nerve filaments.
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作者简介
Victor Mashin
Ulyanovsk State University
编辑信件的主要联系方式.
Email: victor_mashin@mail.ru
ORCID iD: 0000-0003-0085-3727
MD, Professor, Head of the Department of Neurology, Neurosurgery and Medical Rehabilitation of the Faculty of Medicine
俄罗斯联邦, UlyanovskLyudmila Belova
Ulyanovsk State University
Email: labelova@mail.ru
ORCID iD: 0000-0002-9585-5604
MD, Professor of the Department of Neurology, Neurosurgery and Medical Rehabilitation, Dean of the Faculty of Medicine
俄罗斯联邦, UlyanovskEvgeniy Dudikov
Ulyanovsk State University
Email: dudikoveygene80@yandex.ru
ORCID iD: 0000-0002-4105-5687
Assistant at the Department of Neurology, Neurosurgery and Medical Rehabilitation of the Faculty of Medicine
俄罗斯联邦, UlyanovskElena Slesareva
Ulyanovsk State University
Email: gistology2@mail.ru
ORCID iD: 0000-0003-3326-7863
MD, Professor of the Department of General and Clinical Morphology of the Faculty of Medicine named after T.Z. Biktimirov
俄罗斯联邦, UlyanovskDinara Dolgova
Ulyanovsk State University
Email: dolgova.dinara@yandex.ru
ORCID iD: 0000-0001-5475-7031
PhD in Biological Sciences, Associate Professor of the Department of Physiology and Pathophysiology of the Faculty of Medicine named after T.Z. Biktimirov
俄罗斯联邦, UlyanovskKirill Nikishin
Ulyanovsk State University
Email: kirill.nikishin93@mail.ru
ORCID iD: 0000-0003-0125-323X
Resident of the Department of Anesthesiology and Intensive Care, Resident of the Department of Surgery of the Faculty of Postgraduate Education
俄罗斯联邦, UlyanovskYuri Lyalchenko
Ulyanovsk State University
Email: lyalchenko96@yandex.ru
ORCID iD: 0000-0002-8151-8068
5th year student of the Faculty of Medicine
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