Arrhythmic syndrome of undifferentiated connective tissue dysplasia

Ekaterina N. Loginova; Логинова Екатерина Николаевна; Galina I. Nechaeva; Нечаева Галина Ивановна; Anastasia N. Dakuko; Дакуко Анастасия Николаевна; Ilya V. Bogatyrev; Богатырев Илья Вячеславович; Victor V. Potapov; Потапов Виктор Владимирович; Nikolai A. Kirichenko; Кириченко Николай Александрович

doi:10.18565/therapy.2023.9.150-156

Arrhythmic syndrome of undifferentiated connective tissue dysplasia

Authors: Loginova E.N.¹, Nechaeva G.I.¹, Dakuko A.N.¹, Bogatyrev I.V.¹, Potapov V.V.¹^,2, Kirichenko N.A.¹
Affiliations:
1. Omsk State Medical University of the Ministry of Healthcare of Russia
2. Clinical Diagnostic Center
Issue: Vol 9, No 9 (2023)
Pages: 150-156
Section: CLINICAL CASE
URL: https://journals.eco-vector.com/2412-4036/article/view/626172
DOI: https://doi.org/10.18565/therapy.2023.9.150-156
ID: 626172

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Abstract

Cardiac rhythm and conduction disturbances are widespread among patients with hereditary and undifferentiated connective tissue dysplasia. Arrhythmias are the leading cause of serious cardiovascular outcomes in this group of patients. The presented clinical case demonstrates the clinical features and diagnosis of arrhythmic syndrome in a patient with undifferentiated connective tissue dysplasia (UCTD). Phenotypic features of UCTD (asthenic constitution, scoliosis, underweight, joint hypermobility and others) indicated a high diagnostic coefficient of this pathology (more than 23 points) and a possible risk of an unfavorable prognosis. An increase level of the NTproBNP, high-grade ventricular extra systoles and initial signs of longitudinal strain in a young patient (without CHF) may indicate a high cardiovascular risk in patients with phenotypic features of UCTD.

Keywords

undifferentiated connective tissue dysplasia, arrhythmia syndrome, cardiovascular risk

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About the authors

Ekaterina N. Loginova

Omsk State Medical University of the Ministry of Healthcare of Russia

Author for correspondence.
Email: ekaterina.n.loginova@yandex.ru
ORCID iD: 0000-0002-0601-7044

PhD in Medical Sciences, Associate Professor, Associate Professor of the Department of Internal Medicine and Family Medicine with course of Additional Professional Education

Russian Federation, Omsk

Galina I. Nechaeva

Omsk State Medical University of the Ministry of Healthcare of Russia

Email: profnechaeva@yandex.ru
ORCID iD: 0000-0002-2255-128X

MD, Professor, Professor of the Department of Internal Medicine and Family Medicine with course of Additional Professional Education

Russian Federation, Omsk

Anastasia N. Dakuko

Omsk State Medical University of the Ministry of Healthcare of Russia

Email: doc-man85@mail.ru
ORCID iD: 0000-0001-8390-343X

PhD in Medical Sciences, Associate Professor of the Department of Internal Medicine and Family Medicine with course of Additional Professional Education

Russian Federation, Omsk

Ilya V. Bogatyrev

Omsk State Medical University of the Ministry of Healthcare of Russia

Email: ilyabogatyrev23339@icloud.com
ORCID iD: 0000-0003-4016-2023

student of the 515th group of the Faculty of General Medicine

Russian Federation, Omsk

Victor V. Potapov

Omsk State Medical University of the Ministry of Healthcare of Russia; Clinical Diagnostic Center

Email: potapovvv@mail.ru
ORCID iD: 0000-0002-3823-7367

PhD in Medical Sciences, Associate Professor, Associate Professor of the Department of Internal Medicine and Family Medicine with Course of Additional Professional Education

Russian Federation, Omsk; Omsk

Nikolai A. Kirichenko

Omsk State Medical University of the Ministry of Healthcare of Russia

Email: honomer_1608@mail.ru
ORCID iD: 0000-0002-8411-0973

Junior Researcher at Central Scientific Research Laboratory

Russian Federation, Omsk

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