Factors and mechanism of development of infectious and non-infectious pharyngitis

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The main endogenous factors in the development of pharyngitis are gastroesophageal and laryngopharyngeal reflux, chronic rhinitis, rhinosinusitis, adenoiditis, systemic vasculitis (Kawasaki or Behcet’s disease), thyroid disease. Exogenous factors that affect mucous membrane of the oropharynx include pollutants (sulfur dioxide, nitrogen dioxide, etc.), carbon dioxide, toxic production factors emitted at various industrial enterprises, in printing houses, livestock and agro-industrial farms, living conditions at home or in offices associated with the development of sick building syndrome (SBS), tobacco smoke and smoking e-cigarettes, increased vocal loads, use of inhaled glucocorticosteroids and angiotensin-converting enzyme inhibitors. The impact of these factors can change biocenosis of the mucous membrane of palatine tonsils and posterior pharyngeal wall and provoke the development of an infectious process, forming interdependent correlations.

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作者简介

Elena Savlevich

M.F. Vladimirsky Moscow Regional Research Clinical Institute; Clinical Hospital of the Presidential Administration of the Russian Federation

编辑信件的主要联系方式.
Email: savllena@gmail.com
ORCID iD: 0000-0003-4031-308X
SPIN 代码: 7000-3714

MD, Dr. Sci. (Medicine), associate professor, otolaryngologist

俄罗斯联邦, Moscow; Moscow

Pyotr Markus

Polyclinic No. 3 of the Presidential Administration of the Russian Federation

Email: markusp@inbox.ru
ORCID iD: 0000-0003-2564-6601

MD, head of the Department of otolaryngology with surdology and hearing aid room

俄罗斯联邦, Moscow

Tatyana Kabanova

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Email: kabanova75@yandex.ru
ORCID iD: 0009-0000-0990-2535
SPIN 代码: 9358-1745

MD, PhD (Medicine), head of the multidisciplinary day hospital

俄罗斯联邦, Moscow

Andrey Yastremsky

Tyumen Medical University of the Ministry of Healthcare of Russia

Email: yastrem-andrej97@yandex.ru
ORCID iD: 0000-0002-7760-4860
SPIN 代码: 8186-5360

MD, Dr. Sci. (Medicine), professor, head of the Department of otolaryngology

俄罗斯联邦, Tyumen

Anastasia Kagan

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Email: njuk20@yandex.ru
ORCID iD: 0009-0004-1868-3169

MD, pulmonologist

俄罗斯联邦, Moscow

Kirill Bessonov

Bionorica LLC

Email: i@kbessonov.ru
ORCID iD: 0009-0009-5182-3668

medical marketing manager

俄罗斯联邦, Moscow

参考

  1. Коркмазов М.Ю., Ленгина М.А., Коркмазов А.М., Корнова Н.В., Белошангин А.С. Лечение и профилактика различных форм ларингита на фоне острых респираторных инфекций. Медицинский совет. 2022;16(8):79–87. [Korkmazov MYu, Lengina MA, Korkmazov АM, Kornova NV, Beloshangin АS. Treatment and prevention of various forms of laryngitis on the background of acute respiratory infections. Meditsinskiy sovet = Medical Council. 2022;16(8):79–87 (In Russ.)]. EDN: NTPGJN. https://doi.org/10.21518/2079-701X-2022-16-8-79-87
  2. Гизингер О.А., Коркмазов М.Ю., Щетинин С.А. Анамнестические особенности детей с хроническим аденоидитом. Российская оториноларингология. 2017;(3):24–29. [Gizinger OA, Korkmazov MYu, Shchetinin SA. The specific aspects of anamnesis of children with chronic adenoiditis. Rossiyskaya otorinolaringologiya = Russian Otorhinolaryngology. 2017;(3):24–29 (In Russ.)]. EDN: YUBOQJ. https://doi.org/10.18692/1810-4800-2017-
  3. Дайхес Н.А., Баранов А.А., Лобзин Ю.В., Намазова-Баранова Л.С., Козлов Р.С., Поляков Д.П. с соавт. Современные клинические рекомендации по ведению пациентов с острыми тонзиллитом и фарингитом. Педиатрическая фармакология. 2025;22(2):164–177. [Dayhes NA, Baranov AA, Lobzin YuV, Namazova-Baranova LS, Kozlov RS, Polyakov DP et al. Modern clinical guidelines for the management of patients with acute tonsillitis and pharyngitis. Pediatricheskaya farmakologiya = Pediatric Pharmacology. 2025;22(2):164–177 (In Russ.)]. EDN: AAFZJQ. https://doi.org/10.15690/pf.v22i2.2897
  4. Мелехина Е.В., Музыка А.Д., Плоскирева А.А., Сидельникова Э.С., Погорелова О.О., Горелов А.В. Комплексный подход к терапии острых тонзиллофарингитов у детей старше 1 года. РМЖ. 2019;27(10):22–25. [Melekhina EV, Muzyka AD, Ploskireva AA, Sidelnikova ES, Pogorelova OO, Gorelov AV. An integrated approach to the treatment of acute tonsillopharyngitis in children over 1 year old. Russkiy meditsinskiy zhurnal = Russian Medical Journal. 2019;27(10):22–25 (In Russ.)]. EDN: SEEZDY.
  5. Извин А.И., Ястремский А.П., Воркушин А.И. О дифференциальной диагностике острых флегмонозных заболеваний глотки. Российская оториноларингология. 2015;(6):84–89. [Izvin AI, Yastremsky AP, Vorkushin AI. Аbout the differential diagnostics of acute phlegmonous pharyngeal diseases. Rossiyskaya otorinolaringologiya = Russian Otorhinolaryngology. 2015;(6):84–89 (In Russ.)]. EDN: VBCLVD. https://doi.org/10.18692/1810-4800-2015-6-84-89
  6. Савлевич Е.Л., Маркус П.В., Анготоева И.Б., Кириченко И.М., Бессонов К.К. Причины болевого синдрома при воспалительных заболеваниях ротоглотки. Терапия. 2024;10(6):162–168. [Savlevich EL, Markus PV, Angotoeva IB, Kirichenko IM, Bessonov KK. Causes of pain syndrome in case of oropharynx inflammatory diseases. Terapiya = Therapy. 2024;10(6):162–168 (In Russ.)]. EDN: VHJZTI. https://dx.doi.org/10.18565/therapy.2024.6.162-168
  7. Косяков С.Я., Анготоева И.Б., Исамов А.Н. Неинфекционные причины хронического фарингита. Медицинский совет. 2018;(20):112–115. [Kosyakov SY, Angotoeva IB, Isamov AN. Non-infectious causes of chronic pharyngitis. Meditsinskiy sovet = Medical Council. 2018;(20):112–115 (In Russ.)]. EDN: YNGRSX. https://doi.org/10.21518/2079-701X-2018-20-112-115
  8. Холодов А.С., Кириченко К.Ю., Задорнов К.С., Голохваст К.С. Влияние твердых взвешенных частиц атмосферного воздуха населенных пунктов на здоровье человека. Вестник Камчатского государственного технического университета. 2019;(49):81–88. [Kholodov AS, Kirichenko KYu, Zadornov KS, Golokhvast KS. Effect of particulate matter in the air of residential areas on human health. Vestnik Kamchatskogo gosudarstvennogo tekhnicheskogo universiteta = Bulletin of Kamchatka State Technical University. 2019;(49):81–88 (In Russ.)]. EDN: TEZQAU. http://dx.doi.org/10.17217/2079-0333-2019-49-81-88
  9. Zhao X, Lu M, An Z, Li J, Li H, Zhao Q et al. Acute effects of ambient air pollution on hospital outpatients with chronic pharyngitis in Xinxiang, China. Int J Biometeorol. 2020;64(11):1923–31. PMID: 32780156. http://dx.doi.org/10.1007/s00484-020-01980-3
  10. Niewiadomska E, Kowalska M, Czech E. The risk of respiratory incidents in response to the increase of ozone concentration in the ambient air, in the Silesian Voivodeship, in 2016–2017. Przegl Epidemiol. 2022;76(2):216–29. PMID: 36218177. http://dx.doi.org/10.32394/pe.76.22
  11. Красильникова Е.С., Зайнуллина О.Н., Хисматуллина З.Р. Нейропептиды и их роль в патогенезе почесухи взрослых. Клиническая дерматология и венерология. 2023;22(3):324–328. [Krasilnikova ES, Zainullina ON, Khismatullina ZR. Neuropeptides and their role in the pathogenesis of adult prurigo. Klinicheskaya dermatologiya i venerologiya = Russian Journal of Clinical Dermatology and Venereology. 2023;22(3):324–328 (In Russ.)]. EDN: IQCJZS. https://doi.org/10.17116/klinderma202322031324
  12. Ishigami A, Kikuchi Y, Iwasawa S, Nishiwaki Y, Takebayashi T, Tanaka S, Omae K. Volcanic sulfur dioxide and acute respiratory symptoms on Miyakejima island. Occup Environ Med. 2008;65(10):701–7. PMID: 18801927. http://dx.doi.org/10.1136/oem.2007.033456
  13. Lacroix JS, Landis BN. Neurogenic inflammation of the upper airway mucosa. Rhinology. 2008;46(3):163–65. PMID: 18853864.
  14. Renner B, Mueller CA, Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res. 2012;61(10):1041–52. PMID: 22890476. PMCID: PMC3439613. http://dx.doi.org/10.1007/s00011-012-0540-9
  15. Liu YH, Du CL, Lin CT, Chan CC, Chen CJ, Wang JD. Increased morbidity from nasopharyngeal carcinoma and chronic pharyngitis or sinusitis among workers at a newspaper printing company. Occup Environ Med. 2002;59(1):18–22. PMID: 11836464. PMCID: PMC1740204. http://dx.doi.org/10.1136/oem.59.1.18
  16. Schiffman SS, Walker JM, Dalton P, Lorig TS, Raymer JH, Shusterman D, Williams CM. Potential health effects of odor from animal operations, wastewater treatment, and recycling of byproducts. J Agromed. 2004;9(2):397–403. PMID: 19785232.
  17. Athanasiou M, Makrynos G, Dounias G. Respiratory health of municipal solid waste workers. Occup Med (Lond). 2010;60(8):618–23. PMID: 20819804. http://dx.doi.org/10.1093/occmed/kqq127
  18. Wing S, Wolf S. Intensive livestock operations, health, and quality of life among eastern North Carolina residents. Environ Health Perspect. 2000;108(3):233–38. PMID: 10706529. PMCID: PMC1637983. http://dx.doi.org/10.1289/ehp.00108233
  19. Ohayo-Mitoko GJ, Kromhout H, Simwa JM, Boleij JS, Heederik D. Self reported symptoms and inhibition of acetylcholinesterase activity among Kenyan agricultural workers. Occup Environ Med. 2000;57(3):195–200. PMID: 10810102. PMCID: PMC1739922. http://dx.doi.org/10.1136/oem.57.3.195
  20. Zuskin E, Mustajbegovic J, Schachter EN, Kern J, Deckovic-Vukres V, Trosic I, Chiarelli A. Respiratory function in pesticide workers. J Occup Environ Med. 2008;50(11):1299–305. PMID: 19001956. http://dx.doi.org/10.1097/JOM.0b013e3181845f6c
  21. Makinen TM, Juvonen R, Jokelainen J, Harju TH, Peitso A, Bloigu A et al. Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections. Respir Med. 2009;103(3):456–62. PMID: 18977127. http://dx.doi.org/10.1016/j.rmed.2008.09.011
  22. Joshi SM. Sick building syndrome. Indian J Occup Environ Med. 2008;12(2):61–64. PMID: 20040980. PMCID: PMC2796751. http://dx.doi.org/10.4103/0019-5278.43262
  23. Ganji V, Kalpana M, Madhusudhan U, John NA, Taranikanti M. Impact of air conditioners on sick building syndrome, sickness absenteeism, and lung functions. Indian J Occup Environ Med. 2023;27(1):26–30. PMID: 37303987. PMCID: PMC10257240. http://dx.doi.org/10.4103/ijoem.ijoem_23_22
  24. Purokivi MK, Hirvonen MR, Randell JT, Roponen MH, Meklin TM, Nevalainen AL et al. Changes in pro-inflammatory cytokines in association with exposure to moisture-damaged building microbes. Eur Respir J. 2001;18(6):951–58. PMID: 11829101. http://dx.doi.org/10.1183/09031936.01.00201201
  25. Triche EW, Belanger K, Bracken MB, Beckett WS, Holford TR, Gent JF et al. Indoor heating sources and respiratory symptoms in nonsmoking women. Epidemiology. 2005;16(3):377–84. PMID: 15824555. http://dx.doi.org/10.1097/01.ede.0000158225.44414.85
  26. Doni BR, Patil S, Peerapur BV, Kadaganchi H, Bhat KG. Estimation and comparison of salivary immunoglobulin A levels in tobacco chewers, tobacco smokers and normal subjects. Oral Health Dent Manag. 2013;12(2):105–11. PMID: 23756426.
  27. Qiu F, Liang CL, Liu H, Zeng YQ, Hou S, Huang S et al. Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? Oncotarget. 2017;8(1):268–84. PMID: 27902485. PMCID: PMC5352117. http://dx.doi.org/10.18632/oncotarget.13613
  28. Hilty M, Wuthrich TM, Godel A, Adelfio R, Aebi S, Burgener SS et al. Chronic cigarette smoke exposure and pneumococcal infection induce oropharyngeal microbiota dysbiosis and contribute to long-lasting lung damage in mice. Microb Genom. 2020;6(12):mgen000485. PMID: 33295863. PMCID: PMC8116676. http://dx.doi.org/10.1099/mgen.0.000485
  29. Абрамова Н.Д., Сощенко Т.Д., Меремьянина Е.А., Солнцева В.К., Железняк В.Н., Свитич О.А. Экспрессия рецепторов врожденного иммунитета TLR3 и TLR7 на уровне слизистых оболочек верхних дыхательных путей у пациентов с тяжелой формой COVID-19. Терапия. 2023;9(2):7–13. [Abramova ND, Soshchenko TD, Meremyanina EA, Solntseva VK, Zheleznyak VN, Svitich OA. Expression of innate immunity tlr3 and tlr7 receptors at the level of the upper respiratory airways’ mucosa in patients with severe COVID-19. Terapiya = Therapy. 2023;9(2):7–13 (In Russ.)]. EDN: IUFRTL. https://dx.doi.org/10.18565/therapy.2023.2.7-13
  30. Савлевич Е.Л., Симбирцев А.С., Чистякова Г.Н., Терехина К.Г., Бацкалевич Н.А. Состояние системного и местного иммунитета при острых назофарингитах на фоне ОРВИ. Терапия. 2021;7(4):57–63. [Savlevich EL, Simbirtsev AS, Chistyakova GN, Terekhina KG, Batskalevich NA. The state of systemic and local immunity in acute nasopharyngitis with ARVI. Terapiya = Therapy. 2021;7(4):57–63 (In Russ.)]. EDN: DQUUKT. https://dx.doi.org/10.18565/therapy.2021.4.57-63
  31. Савлевич Е.Л., Козлов В.С., Анготоева И.Б. Современные представления о роли небных миндалин в системе иммунитета и анализ применения иммунотропных препаратов при хроническом тонзиллите. Российская оториноларингология. 2018;(6):48–55. [Savlevich EL, Kozlov VS, Angotoeva IB. The present-day views of the role of palatine tonsils in the immune system and analysis of application of immunotropic drugs in chronic tonsillitis. Rossiiskaya otorinolaringologiya = Russian Otolaryngology. 2018;(6):48–55 (In Russ.)]. EDN: MIMXTF. https://doi.org/10.18692/1810-4800-2018-6-48-55
  32. Darabseh MZ, Aburub A, Morse CI, Degens H. The association between smoking/vaping habits and self-reported respiratory symptoms. Multidiscip Respir Med. 2024;19(1):976. PMID: 39397788. PMCID: PMC11482041. http://dx.doi.org/10.5826/mrm.2024.976
  33. Van Lierde KM, D’haeseleer E, Wuyts FL, De Ley S, Geldof R, De Vuyst J, Sofie C. The objective vocal quality, vocal risk factors, vocal complaints, and corporal pain in Dutch female students training to be speech-language pathologists during the 4 years of study. J Voice. 2010;24(5):592–98. PMID: 19896799. http://dx.doi.org/10.1016/j.jvoice.2008.12.011
  34. Eckley CA, Sardinha LR, Rizzo LV. Salivary concentration of epidermal growth factor in adults with reflux laryngitis before and after treatment. Ann Otol Rhinol Laryngol. 2013;122(7):440–44. PMID: 23951695. http://dx.doi.org/10.1177/000348941312200705
  35. Vardouniotis AS, Karatzanis AD, Tzortzaki E, Athanasakis E, Samara KD, Chalkiadakis G et al. Molecular pathways and genetic factors in the pathogenesis of laryngopharyngeal reflux. Eur Arch Otorhinolaryngol. 2009;266(6):795–801. PMID: 19340444. http://dx.doi.org/10.1007/s00405-009-0966-z
  36. Barry DW, Vaezi MF. Laryngopharyngeal reflux: More questions than answers. Cleve Clin J Med. 2010;77(5):327–34. PMID: 20439565. http://dx.doi.org/10.3949/ccjm.77a.09121
  37. Buhl R. Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. Allergy. 2006;61(5):518–26. PMID: 16629778. http://dx.doi.org/10.1111/j.1398-9995.2006.01090.x
  38. Borghi C, Cicero AF, Agnoletti D, Fiorini G. Pathophysiology of cough with angiotensin-converting enzyme inhibitors: How to explain within-class differences? Eur J Intern Med. 2023;110:10–15. PMID: 36628825. http://dx.doi.org/10.1016/j.ejim.2023.01.005
  39. Kunz MJ, Martini WA, Filler L. The rare sore throat: A case of thyroid storm and agranulocytosis. Clin Pract Cases Emerg Med. 2024;8(1):34–37. PMID: 38546308. PMCID: PMC10966501. http://dx.doi.org/10.5811/cpcem.6609
  40. Савлевич Е.Л., Иванова М.А., Мокроносова М.А., Горбунов С.А., Якушенкова А.П. Сезонные особенности микробного пейзажа небных миндалин у здоровых студентов. Журнал микробиологии, эпидемиологии и иммунобиологии. 2018;(5):98–103. [Savlevich EL, Ivanova MA, Mokronosova MA, Gorbunov SA, Yakushenkova AP. Seasonal features of the microbial landscape of palatine tonsils in healthy students. Zhurnal mikrobiologii, epidemiologii i immunobiologii = Journal of Microbiology, Epidemiology and Immunobiology. 2018;(5):98–103 (In Russ.)]. EDN: VCUQQQ. https://doi.org/10.36233/0372-9311-2018-5-98-103
  41. Давтян Н.Р., Клур М.В., Асланов Б.И., Гордеева С.А., Погромская М.Н., Гончаров А.Е. Современные этиологические особенности бактериальных гнойно-воспалительных поражений фаринготонзиллярной зоны у пациентов с острыми респираторными вирусными инфекциями. Профилактическая и клиническая медицина. 2024;(2):74–81. [Davtyan NR, Klur MV, Aslanov BE, Gordeeva SA, Рogromskaya MN, Goncharov АЕ. Modern etiological features of bacterial purulent-inflammatory lesions of the pharyngotonsillar zone in patients with acute respiratory viral infections. Profilakticheskaya i klinicheskaya meditsina = Preventive and Clinical Medicine. 2024;(2):74–81 (In Russ.)]. EDN: YDKJYU.
  42. Пайганова Н.Э., Ястремский А.П. Перспективы применения антимикробных пептидов в оториноларингологии в условиях растущей антибиотикорезистентности. Вестник оториноларингологии. 2021;86(3):104–109. [Payganova NE, Yastremskiy AP. Prospects of antimicrobial peptides application in otorhinolaryngology in conditions of increasing antibiotic resistance. Vestnik otorinolaringologii = Russian Bulletin of Otorhinolaryngology. 2021;86(3):104–109 (In Russ.)]. EDN: LUPIQR. https://doi.org/10.17116/otorino202186031104
  43. Савлевич Е.Л., Дорощенко Н.Э., Славинская И.С., Фариков С.Э. Важные нюансы воспалительного процесса в ротоглотке и выбор тактики оптимального лечения. Медицинский совет. 2017;(16):48–54. [Savlevich EL, Doroschenko NE, Slavinskaya IS, Farikov S.E. Important factors of the inflammatory process in the oropharynx and optimal treatment regimes selection. Meditsinskiy sovet = Medical Council. 2017;(16):48–54 (In Russ.)]. EDN: ZRDSRJ. https://doi.org/10.21518/2079-701X-2017-16-48-54
  44. Овчинников А.Ю., Мирошниченко Н.А., Щербаков А.Ю., Атлашкин Д.Н. Диоксидин – неизменный фаворит в лечении воспалительных заболеваний лор-органов: 45 лет вместе. Эффективная фармакотерапия. 2022;18(28):42–46. [Ovchinnikov AYu, Miroshnichenko NA, Shcherbakov AYu, Atlashkin DN. Dioxidine is a constant favorite in the treatment of inflammatory diseases of the upper respiratory tract: 45 years together. Effektivnaya farmacotherapiya = Effective Pharmacotherapy. 2022;18(28):42–46 (In Russ.)]. EDN: WTRDXD. https://doi.org/10.33978/2307-3586-2022-18-28-42-46
  45. Okshevsky M, Regina VR, Meyer RL. Extracellular DNA as a target for biofilm control. Curr Opin Biotechnol. 2015;33:73–80. PMID: 25528382. https://doi.org/10.1016/j.copbio.2014.12.002
  46. Овчинников А.Ю., Мирошниченко Н.А., Николаева Ю.О. Рекомендации по топической антимикробной терапии воспалительных заболеваний среднего уха по результатам доказательного клинического исследования. Медицинский совет. 2024;18(7):52–63. [Ovchinnikov AYu, Miroshnichenko NA, Nikolaeva YuO. Recommendations for topical antimicrobial therapy of inflammatory diseases of the middle ear based on the results of evidence-based clinical study. Meditsinskiy sovet = Medical Council. 2024;18(7):52–63 (In Russ.)]. EDN: AVUOHG. https://doi.org/10.21518/ms2024-108
  47. Еремеева К.В., Наговская В.В., Морозова С.В. Гидроксиметилхиноксалиндиоксид – точки приложения в оториноларингологии. Медицинский совет. 2023;17(7):72–79. [Eremeeva KV, Nagovskaya VV, Morozova SV. Hydroxymethylquinoxalindioxide as levarage points for otorhinolaryngology. Meditsinskiy sovet = Medical Council. 2023;17(7):72–79 (In Russ.)]. EDN: CNKILZ. https://doi.org/10.21518/ms2023-119

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