Algorithm for differential diagnosis of Miller Fisher Syndrome in real clinical practice

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Miller Fisher syndrome (MFS), being one of the variants of Guillain – Barre syndrome, refers to acute dysimmune neuropathies with a triad of symptoms in the form of ataxia, ophthalmoplegia and areflexia. The article presents a case of MFS in a 69-year-old female patient, which debuted in a week after the development of pneumonia with rapid arising of complete ophthalmoplegia, ataxia and decreased tendon reflexes. After excluding brainstem stroke, the diagnosis of MFS was made. A high titer of antibodies to gangliosides GT1A, GQ1B was observed in patient’s blood. Plasmapheresis was accompanied by complete regression of ataxia with preservation of ophthalmoplegia. Two months after the start of therapy, antibody titers significantly decreased, and mild ataxic syndrome persisted in the neurological status. Early diagnosis of MFS determines the timely administration of pathogenetic therapy, which contributes to a good outcome of the disease.

全文:

受限制的访问

作者简介

Ekaterina Ostapchuk

Regional Clinical Hospital No. 1; Tyumen State Medical University of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: ostapchukes2008@mail.ru
ORCID iD: 0000-0003-1176-4113
SPIN 代码: 6877-6140

MD, PhD (Medicine), head of the Department of neurology, associate professor of the Department of neurology with a course in neurosurgery of the Institute of clinical medicine

俄罗斯联邦, Tyumen; Tyumen

Vitaliy Kuznetsov

Regional Clinical Hospital No. 1

Email: Vitalij.kuzneczov.1996@mail.ru
ORCID iD: 0009-0003-7721-1682

MD, neurologist at the Department of neurology

俄罗斯联邦, Tyumen

参考

  1. Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M. Guillain – Barre syndrome spectrum associated with COVID-19: An up-to-date systematic review of 73 cases. J Neurol. 2021;268(4):1133–70. PMID: 32840686. PMCID: PMC7445716. https://doi.org/10.1007/s00415-020-10124-x
  2. Gomez A, Diaz A, Carrion-Penagos J, Reyes J, Reyes S. Clinical and electrophysiological characteristics of Guillain – Barre syndrome in Colombia. J Peripher Nerv Syst. 2019;24(3):268–71. PMID: 31386254. https://doi.org/10.1111/jns.12340
  3. Hsueh HW, Chang KC, Chao CC, Hsieh ST. A pilot study on serial nerve ultrasound in Miller Fisher syndrome. Front Neurol. 2020;11:865. PMID: 32922359. PMCID: PMC7457056. https://doi.org/10.3389/fneur.2020.00865
  4. Bukhari S, Taboada J. A case of Miller Fisher syndrome and literature review. Cureus. 2017;9(2):e1048. PMID: 28367386. PMCID: PMC5362277. https://doi.org/10.7759/cureus.1048
  5. Синдром Гийена – Барре. Клинические рекомендации. Под общей редакцией акад. РАН Пирадова М.А., проф. РАН Супоневой Н.А., к. м. н. Гришиной Д.А. М.: Горячая линия – Телеком. 2018; 32 с. [Guillain – Barre syndrome. Clinical guidelines. Ed. by of academician of RAS Piradov MA, professor of RAS Suponeva NA, PhD (Medicine) Grishina DA. Moscow: Hotline – Telecom Scientific and Technical Publishing House. 2018; 32 pp. (In Russ.)]. ISBN: 978-5-9912-0748-5.
  6. Noioso CM, Bevilacqua L, Acerra GM, Valle PD, Serio M, Pecoraro A et al. The spectrum of anti-GQ1B antibody syndrome: Beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis. Neurol Sci. 2024;45(12):5657–69. PMID: 38987510. https://doi.org/10.1007/s10072-024-07686-3
  7. Svennerholm L. Designation and schematic structure of gangliosides and allied glycosphingolipids. Prog Brain Res. 1994;101:XI–XIV. PMID: 8029441. https://doi.org/10.1016/S0079-6123(08)61935-4
  8. Левин О.С. Полинейропатии. Клиническое руководство. 3-е изд., испр. и доп. М.: МИА. 2016; 480 с. [Levin OS. Polyneuropathies. Clinical guidelines. 3rd edition, corrected and supplemented. Moscow: Medical News Agency. 2016; 480 pp. (In Russ.)]. ISBN: 5998602633. ISBN-13(EAN): 9785998602634.
  9. Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR et al. Diagnosis and management of Guillain – Barre syndrome in ten steps. Nat Rev Neurol. 2019;15(11):671–83. PMID: 31541214. PMCID: PMC6821638. https://doi.org/10.1038/s41582-019-0250-9
  10. Doets AY, Hughes RA, Brassington R, Hadden RD, Pritchard J. Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain – Barre syndrome. Cochrane Database Syst Rev. 2020;1(1):CD008630. PMID: 31981368. PMCID: PMC6984651. https://doi.org/10.1002/14651858.CD008630.pub5
  11. [Suzuki C. Fisher syndrome. Brain Nerve. 2024;76(5):508–14 (In Japanese)]. PMID: 38741489. https://doi.org/10.11477/mf.1416202636

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2025