Duodenal digestive function in the treatment of patients with chronic duodenal insufficiency

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Of great interest is Not only the study of the functional state of duodenum (DU), but also the search for pathogenetically reasoned treatment regimens for chronic duodenal insufficiency (CDI) that improve hydrolysis processes in the duodenum are of great interest nowadays.

The aim: to determine the efficacy of complex treatment for CDI patients with impaired duodenal parietal digestion.

Material and methods. The study included 110 patients with CDI stratified by disease stage (1–3) using machine learning. In patients with stages 1–2 CDI, intestinal duodenal mucosal carbohydrase activity was measured using a modified A. Dahlquist method. Duodenal intestinal alkaline phosphatase (ALP) isoform activity was also measured. Then patients with stage 1 CDI (n = 55) were prescribed mebeverine, rebamipide, and Lactobacillus plantarum DR7; patients with stage 2 CDI (n = 40) were prescribed itopride, rebamipide, and Lactobacillus plantarum DR7. Digestive function of duodenum was estimated before and after the treatment course.

Results. A study of the activity of parietal enzymes in duodenal mucosa in all patients with chronic duodenal failure revealed a decrease in the baseline levels of carbohydrases and alkaline phosphatase in duodenal contents comparatively to the control group (50 apparently healthy individuals). After comprehensive treatment, participants with stages 1 and 2 chronic duodenal insufficiency had restoration of parietal carbohydrase activity and intestinal alkaline phosphatase isoform.

Conclusion. Using of comprehensive personalized therapy in patients with chronic duodenal insufficiency allowed to restore the parietal digestion disorders in duodenum.

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作者简介

Yakov Vakhrushev

Izhevsk State Medical Academy of the Ministry of Healthcare of Russia

Email: spacocubo@gmail.com
SPIN 代码: 1286-8503

MD, Dr. Sci. (Medicine), professor, head of the Department of internal medicine propaedeutics with nursing course

俄罗斯联邦, Izhevsk

Marina Busygina

Izhevsk State Medical Academy of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: marina.busygina.login@gmail.com
ORCID iD: 0000-0003-1740-2391
SPIN 代码: 1249-6340

MD, PhD (Medicine), associate professor of the Department of internal medicine propaedeutics with nursing course

俄罗斯联邦, Izhevsk

Natalia Khokhlacheva

Izhevsk State Medical Academy of the Ministry of Healthcare of Russia

Email: stoxel@yandex.ru

MD, Dr. Sci. (Medicine), professor of the Department of internal medicine propaedeutics with nursing course

俄罗斯联邦, Izhevsk

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