The evaluation of lipid profile in patients with chronic heart failure and concomitant chronic obstructive pulmonary disease
- Авторлар: Vatutin N.T.1,2, Smirnova A.S.1,2, Gasendich Y.S.1
-
Мекемелер:
- M. Gorky Donetsk national medical university
- V.K. Gusak Institute of urgent and reconstructive surgery
- Шығарылым: № 6 (2016)
- Беттер: 30-35
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/277732
- ID: 277732
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Purpose of study. The revaluation of the main indicators of the Lipid profite in patients with chronic heart faiture (CHF) and concomitant chronic obstructive pulmonary disease (COPD). Materials and methods. The study included 102 patients (58 men and 44 women, mean age 65.7±4.5 years). According to the results of spirometry all patients were divided into 2 groups: the basic group included 54 patients suffering from CHF in conjunction with COPD, the control included 48 patients with CHF without bronchopulmonary pathology. The Lipid profite was determined by the level of the total cholesterol (TC), triglycerides, high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL-C), and the concentration of C-reactive protein (CRP), interteukin-8 and tumor necrosis factor-α. Results. Patients with comorbid disorders had a higher levels of TC and LDL-C, Low HDL-C concentration. According to the result of the correlation analysis we identified the positive correlation relationship between cholesterol, CRP and pro-inftammatory cytokines. Conclusions. The combination of CHF and COPD is associated with the development of the lipid metabolism disorders, manifested as hypercholesterolemia, high LDL and low HDL cholesterol that are most likely caused by activation of systemic inflammatory response.
Толық мәтін
Авторлар туралы
Nikolai Vatutin
M. Gorky Donetsk national medical university; V.K. Gusak Institute of urgent and reconstructive surgery
Email: kafedra_vatutin@mail.ru
MD, professor, head of the Department of hospital therapy; deputy head of the Department of emergency cardiology and cardiac surgery
Anna Smirnova
M. Gorky Donetsk national medical university; V.K. Gusak Institute of urgent and reconstructive surgery
Email: a.smyrnova@mail.ru
PhD, assistant professor of the Department of hospital therapy; senior researcher of the Department of emergency cardiology and cardiac surgery
Yekaterina Gasendich
M. Gorky Donetsk national medical universityclinical intern of the Department of hospital therapy
Әдебиет тізімі
- Mozaffarian D., Benjamin E.J., Go A.S., Arnett D.K., Blaha M.J., Cushman M. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation. 2015;131(4):29-322.
- Ватутин Н.Т., Калинкина Н.В., Ещенко Е.В. Диагностика и лечение острой и хронической сердечной недостаточности: новое в рекомендациях European Society of Cardiology (2012). Практична ангіологія. 2012;7-8(56-57):5-13. [Vatutin N.T., Kalinkina N.V., Eshchenko Ye.V. Diagnosis and treatment of acute and chronic heart failure: the new recommendations in the European Society of Cardiology (2012). Practical angiology. 2012;7-8(56-57):5-13 (in Russian)]
- Pellegrino R., Viegi G., Brusasco V., Crapo R.O., Burgos F., Casaburi R., Coates A., van der Grinten C.P., Gustafsson P., Hankinson J., Jensen R., Johnson D.C., MacIntyre N., McKay R., Miller M.R., Navajas D., Pedersen O.F., Wanger J. Interpretative strategies for lung function tests. Eur. Respir. J. 2005;26(5):948-68.
- Чичерина Е.Н., Шипицына В.В., Малых С.В. Сравнительная характеристика клинико-функциональных нарушений сердечно-сосудистой системы у больных хроническим обструктивным бронхитом и бронхиальной астмой. Пульмонология. 2003;(6):97-102. [Chicherina Ye.N., Shipitsyna V.V., Malyh S.V. Comparative characteristics of clinical and functional disorders of the cardiovascular system in patients with chronic obstructive bronchitis and bronchial asthma. Pulmonology. 2003;(6):97-102 (in Russian)]
- Kjoller E., Kober L., Iversen K., Torp-Pedersen C. Importance of chronic obstructive pulmonary disease for prognosis and diagnosis of congestive heart failure in patients with acute myocardial infarction. Eur. J. Heart Fail. 2004;6(1):71-7.
- Куценко М.А., Чучалин А.Г. Парадигма коморбидности: синтропия ХОБЛ и ИБС. РМЖ. 2014;5:389-93. [Kutsenko M.A., Chuchalin A.G. The paradigm of comorbidity: entropia COPD and CAD. Russian medical journal. 2014;5:389-93 (in Russian)]
- Воронков Л.Г. Хроническая сердечная недостаточность и хроническое обструктивное заболевание легких. Серцева недостатність. 2010;1:12-9. [Voronkov L. G. Chronic heart failure and chronic obstructive pulmonary disease. Heart failure. 2010;1:12-9 (in Russian)]
- Parchwani D.N., Upadhyah A.A., Chandan D.H. Effect of active smoking on glucose tolerance and lipid profile. Int J Med Sci Public Health. 2013;2(1):20-5.
- Haj Mouhamed D., Ezzaher A., Neffati F., Gaha L., Douki W., Najjar M.F. Association between cigarette smoking and dyslipidemia. Immuno-analyse & Biologie Spécialisée. 2013;28(4):195-200.
- Chehade J.M., Gladysz M., Mooradian A.D. Dyslipidemia in type 2 diabetes: prevalence, pathophysiology, and management. Drugs. 2013;73(4):327-39.
- Kolovou G.D., Anagnostopoulou K.K., Damaskos D.S., Bilianou H.I., Mihas C., Milionis H.J., Kostakou P.M., Cokkinos D.V. Gender differences in the lipid profile of dyslipidemic subjects. Eur. J. Intern. Med. 2009;20(2):145-51.
- Lira F.S., Rosa Neto J.C., Antunes B.M., Fernandes R.A. The relationship between inflammation, dyslipidemia and physical exercise: from the epidemiological to molecular approach. Curr. Diabetes Rev. 2014;10(6):391-6.
- Лутай М.И., Голикова И.П., Слободской В.А. Роль дисфункции эндотелия, воспаления и дислипидемии в атерогенезе. Укр. кардіол. журн. 2007;5:37-47. [Lutai M.I., Golikova I.P., Slobodskoy V.A. Role of endothelial dysfunction, inflammation and dyslipidemia in atherogenesis. Ukrainian journal of cardiology. 2007;5:37-47 (in Russian)]
- Кнышова В.В., Гвозденко Т.А., Антонюк М.В., Новгородцева Т.П. Фенотипы дислипидемий у пациентов с хроническими заболеваниями бронхолегочной системы. Бюллетень физиологии и патологии дыхания. 2014;51 ;20-7. [Knyshova V.V., Gvozdenko T.A., Antonyuk M.V., Novgorodtseva T.P. Phenotypes of dyslipidemias in patients with chronic diseases of the bronchopulmonary system. Bulletin of physiology and pathology of respiration. 2014;51;20-7 (in Russian)]
Қосымша файлдар
