Role of В group vitamins in the therapy of diabetes melitus complications


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Acesso é pago ou somente para assinantes

Resumo

Diabetic neuropathy (DNP) is the most often complication of diabetes melitus which could be conventionally devided into peripheral DNP touching peripheral nerves, autonomous - with vegetative innervation of organs disorders, and central - with cerebrocranial nerves damage. Often DNP goes with chronic pain syndrome, sharply decreasing life quality of patients and demanding a special therapy. Pathogenetic DNP therapy is performing by means of neurometabolic medicaments, among which vitamin B-based medicaments (thiamine (В1) first of all) occupy the important place. Mechanism of therapeutic effect of thiamine in case of DNP is connected with its ability of slowing glycolysis, lactate generating and final product of glycation, thereby decreasing the toxic effect of hyperglycemia. Moreover, it is zhown, that vitamin B1 independently by itself or in combinations with B6 and B12 vitamins is able to reduce neuropathic pain.

Texto integral

Acesso é fechado

Sobre autores

Anna Pilipovich

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov

Email: aapilipovich@mail.ru
PhD, docent

Alexey Danilov

FGAOU VO «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of Russia

Email: danilov@intermeda.ru
MD, professor of the Department of Neurology in Institute of professional education, Director of the Institute for Interdisciplinary medicine.

Bibliografia

  1. Mursleen M.T., Riaz S. Implication of homocysteine in diabetes and impact of folate and vitamin B12 in diabetic population. Diabetes Metab. Syndr. 2016 Dec 13;12 pii: S1871-4021(16):30272-7.
  2. Zeng L., Alongkronrusmee D., van Rijn R.M. An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US. J. Pain Res. 2017;10:219-28.
  3. Xu Z., Zhang P., Long L., He H., Zhang J., Sun S. Diabetes mellitus in classical trigeminal neuralgia: a predisposing factor for its development. Clin. Neurol. Neurosurg. 2016;151:70-2.
  4. Tesfaye S., Boulton A.J., Dickenson A.H. Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care. 2013;36:2456-2460.
  5. Воробьева А.А. Диабетическая нейропатия: некоторые вопросы распространенности, патогенеза и лечения. РМЖ. Неврология. Психиатрия. 2009;11:748-51. [Vorobyova A.A. Diabetic neuropathy: some aspects of prevalence, pathogenesis and treatment. RMJ. Neurology. Psychiatrics. 2009;11:748-51.]
  6. Bettendorff L., Kolb H.A., Schoffeniels E. Thiamine triphosphate activates anion channels of large unit conductance in neuroblastoma cells. J. Membr. Biol. 1993;136:281-8.
  7. Bа A. Metabolic and structural role of thiamine in nervous tissues. Cell. Mol. Neurobiol. 2008;7:923-31.
  8. Дамулин И.В. Терапевтические возможности применения препарата Тригамма® в неврологической практике. Справочник врача общей практики. 2011;7:28-35. [Damulin I.V. Therapeutic possibilities of use of Trigamma® medicine in neurological practice. Manual of general practice doctor. 2011;7:28-35.]
  9. Луцкий И.С., Лютикова Л.В., Луцкий Е.И. Витамины группы В в неврологической практике. Международный неврологический журнал. 2008;5. [Luzkiy I.S., Lutikova L.V., Luzkiy E.I. B group vitamins in neurological practice. International neurological journal. 2008;5.]
  10. Строков И.А., Ахмеджанова Л.Т., Солоха О.А. Витамины группы В в лечении неврологических заболеваний. РМЖ. Неврология. Психиатрия. 2009;1 1:776-84. [Strokov I.A., Akhmedzhanova L.T., Solokha O.A. B group vitamins in treatment of neurologic diseases. RMJ.Neurology. Psychiatrics. 2009;1 1:776-84.]
  11. Nardin R.A., Amic A.N., Raynor E.M. Vitamin B(12) and methylmalonic acid levels in patients presenting with polyneuropathy. Muscle Nerve. 2007;36:4:532-5.
  12. Данилов А.Б., Данилов Ал.Б. Управляй болью. Биопсихосоциальный подход. М.: АММ ПРЕСС, 2012. 582 с. [Danilov A.B., Danilov Al.B. Manage your pain. Biopsychosocial approach. M.: AMMPRESS, 2012, P.582.]
  13. Ang C.D., Alviar M.J., Dans A.L., Bautista-Velez G.G., Villaruz-Sulit M.V., Tan J.J., Co H.U., Bautista M.R., Roxas A.A. Vitamin B for treating peripheral neuropathy. Cochrane Database Syst. Rev. 2008;3:CD004573.
  14. Haupt E., Ledermann H., Köpcke W. Benfotiamine in the treatment of diabetic polyneuropathy - a three-week randomized, controlled pilot study (BEDIP study). Int. J. Clin. Pharmacol. Ther. 2005;2:71-7.
  15. Stracke H., Gaus W., Achenbach U., Federlin K., Bretzel R.G. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical trial. Exp. Clin. Endocrinоl. Diabetes. 2008;1 16(10):600-605.
  16. MacKenzie K.E., Wiltshire E.J., Gent R., Hirte C., Piotto L., Couper J.J. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics. 2006;1:242-53.
  17. Анисимова Е.И., Данилов А.Б. Эффективность бенфотиамина в лечении алкогольной полиневропатии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2001;4:216-21. [Anisimova E.I., Danilov A.B. Efficacy of benfotiamine in alcohol polyneuropathy treatment. Journal of neurology and psychiatrics named after S.S. Korsakov. 2001;4:216-21.]
  18. Sanchez-Ramirez G.M., Caram-Salas N.L., Rocha-Gonzales H.I., Vidal-Cantu G.C., Medina-Santillan R., Reyes-Garcia G., Granados-Soto V. Benfotiamine relieves inflamatory and neuropathic pain in rats. Eur. J. Pharmacol. 2006;150(1-2):48-53.
  19. Moallem S.A., Hosseeinzaden H., Farahi S. A study of acute and chronic anti-nociceptive and anti-inflammatory effects of thiamine in mice. Iran Biomed. J. 2008;12(3):173-8.
  20. Данилов А.Б. Применение витаминов группы В при болях в спине: новые анальгетики? РМЖ. 2008;16:35-3. [Danilov A.B. Use of B group vitamins in case of back pains: new analgesics? RMJ. 2008;16:35-3.]
  21. Kasdan M., Janes C. Carpal tunnel syndrome and vitamin B6. Plast. Reconstr. Surg. 1987;79:456-8.
  22. Aufiero E., Stitik T., Foye M., Chen B. Piridoxine hydrochloride treatment of carpal tunnel syndrome: a review. Nutr. Rev. 2004;3:96-104.
  23. Katan M.B. How much vitamin B6 is toxic? Ned. Tijdschr. Geneeskd. 2005;46:2545-6.
  24. Mauro G.L., Martorana U., Cataldo P., Brancato G., Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebocontrolled study. Eur. Rev. Med. Pharmacol. Sci. 2000;4(3):53-8.
  25. Talaei A., Siavash M., Majidi H., Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int. J. Food Sci. Nutr. 2009;60(Suppl 5):71-6.
  26. Chiu C.K., Low T.H., Tey Y.S., Singh V.A., Shong H.K. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial. Singapore Med. J. 2011;52(12):868-73.
  27. Садырин А.В., Карпова М.И., Долганов М.В. Диабетическая полинейропатия: вопросы патогенеза и возможности лечения. РМЖ. 2016;1:47-50. [Sadyrin A.V., Karpova M.I., Dolganov M.V. Diabetic polyneuropathy: aspects of pathogenesis and possibilities of treatment. RMJ. 2016;1:47-50.]
  28. Старчина Ю.А. Витамины группы В в лечении заболеваний нервной системы. Неврология, нейропсихиатрия, психосоматика. 2009;2:84-7. [Starchina Ju.A. B group vitamins in treatment of nervous system diseases. Neurology, neuropsychiatrics, psychosomatics. 2009;2:84-7.]
  29. Bruggemann G., Koehler C.O., Koch E.M. Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebre. A multicenter study. Klein Wochenschr. 1990;2:116-20.
  30. Kulwein A., Meyer H.J., Koehler C.O. Reduced diclofenac administration by B vitamins: results of a randomized double-blined study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitsmins) in acute lumbar vertebral syndromes. Klein Wochenschr. 1990;2:107-15.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar

Declaração de direitos autorais © Bionika Media, 2017

Este site utiliza cookies

Ao continuar usando nosso site, você concorda com o procedimento de cookies que mantêm o site funcionando normalmente.

Informação sobre cookies