Role of В group vitamins in the therapy of diabetes melitus complications
- 作者: Pilipovich A.A.1, Danilov A.B.2
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隶属关系:
- Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov
- FGAOU VO «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of Russia
- 期: 编号 7 (2017)
- 页面: 50-54
- 栏目: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/279147
- ID: 279147
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详细
Diabetic neuropathy (DNP) is the most often complication of diabetes melitus which could be conventionally devided into peripheral DNP touching peripheral nerves, autonomous - with vegetative innervation of organs disorders, and central - with cerebrocranial nerves damage. Often DNP goes with chronic pain syndrome, sharply decreasing life quality of patients and demanding a special therapy. Pathogenetic DNP therapy is performing by means of neurometabolic medicaments, among which vitamin B-based medicaments (thiamine (В1) first of all) occupy the important place. Mechanism of therapeutic effect of thiamine in case of DNP is connected with its ability of slowing glycolysis, lactate generating and final product of glycation, thereby decreasing the toxic effect of hyperglycemia. Moreover, it is zhown, that vitamin B1 independently by itself or in combinations with B6 and B12 vitamins is able to reduce neuropathic pain.
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作者简介
Anna Pilipovich
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov
Email: aapilipovich@mail.ru
PhD, docent
Alexey Danilov
FGAOU VO «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of Russia
Email: danilov@intermeda.ru
MD, professor of the Department of Neurology in Institute of professional education, Director of the Institute for Interdisciplinary medicine.
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