Sex hormones in pain management


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Resumo

The problem of the role of sex hormones (SG) in pain perception and their possible place in pain syndromes of different genesis treatment is discussed. The majority of research works describe the correlation between SG blood level and pain severity in male and female patients. The overwhelming majority of chronic pain syndromes in females (migrainous headache, pain in maxillotemporal joint dysfunction, сhronic pelvic pain, etc.) have similar clinical course during menstrual cycle period: the lowest pain threshold and maximal pain sensibility under low levels of estrogen. Also it is becoming obvious the influence of blood testosterone deficiency at antiinflammatory status intensity in males, taking into account coexisting insufficient supression of the expression and inflammatory mediators' release - cytokines and chemokines. In such a way, SG balance disorder in male and female organisms helps pronocyceptive effects' generation. Early correction of SG level in neurologist's practice increases the efficaххcy of pain syndromes' therapy.

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Sobre autores

Alexey Danilov

FGAOU VO «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of Russia

Email: danilov@intermeda.ru
MD, professor of the Department of Neurology in Institute of professional education, Director of the Institute for Interdisciplinary medicine.

Roman Iljasov

I.M. Sechenov First Moscow state medical university of the Ministry of Health of Russia

Email: romamma@mail.ru
Ph.D. candidate of the Department of neuropathology

Bibliografia

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