Sex hormones in pain management


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The problem of the role of sex hormones (SG) in pain perception and their possible place in pain syndromes of different genesis treatment is discussed. The majority of research works describe the correlation between SG blood level and pain severity in male and female patients. The overwhelming majority of chronic pain syndromes in females (migrainous headache, pain in maxillotemporal joint dysfunction, сhronic pelvic pain, etc.) have similar clinical course during menstrual cycle period: the lowest pain threshold and maximal pain sensibility under low levels of estrogen. Also it is becoming obvious the influence of blood testosterone deficiency at antiinflammatory status intensity in males, taking into account coexisting insufficient supression of the expression and inflammatory mediators' release - cytokines and chemokines. In such a way, SG balance disorder in male and female organisms helps pronocyceptive effects' generation. Early correction of SG level in neurologist's practice increases the efficaххcy of pain syndromes' therapy.

Full Text

Restricted Access

About the authors

Alexey B. Danilov

FGAOU VO «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of Russia

Email: danilov@intermeda.ru
MD, professor of the Department of Neurology in Institute of professional education, Director of the Institute for Interdisciplinary medicine.

Roman R. Iljasov

I.M. Sechenov First Moscow state medical university of the Ministry of Health of Russia

Email: romamma@mail.ru
Ph.D. candidate of the Department of neuropathology

References

  1. Palmeira C.C., Ashmawi H.A., Posso Ide P. Sex and pain perception and analgesia. Rev. Bras. Anestesiol. 2011;61(6):814-28.
  2. Ильясов Р.Р., Калинченко С.Ю., Данилов А.Б. Роль половых гормонов в восприятии боли. Manage Pain. 2015;2:4-9. [Iljasov R.R., Kalinichenko S.Ju., Danilov A.B. The role of sex hormones in pain perception. Manage Pain. 2015;2:4-9.]
  3. Данилов А.Б., Ильясов Р.Р. Половые гормоны и боль. Журнал неврологии и психиатрии им. C.C. Корсакова. 2017;117(2):149-54. [Danilov A.B., Iljasov R.R. Sex hormones and pain. S.S. Korsakov journal of neurology and psychiatrics. 2017;117(2):149-54.]
  4. LeResche L., Mancl L., Sherman J.J., Gandara B., Dworkin S.F. Changes in temporomandibular pain and other symptoms across the menstrual cycle. Pain. 2003;106:253-61.
  5. Fillingim R.B., Ness T.J. Sex-related hormonal influences on pain and analgesic responses. Neurosci. Biobehav. Rev. 2000;24:485-501.
  6. Данилов А.Б. Роль пола и гендера при мигрени и головной боли напряжения (клинико-психонейрофизиологическое исследование). Дис. Д-ра мед. наук. Москва, 2007. 320 с. [Danilov A.B. The role of sex and gender in case of migraine and tension-type headache (clinical psychoneurophysiological research). Diss. of holder of post-doctoral degree in medicine. Moscow, 2007. P. 320.]
  7. Martin V.T., Wernke S., Mandell K., Ramadan N., Kao L., Bean J., Liu J., Zoma W., Rebar R. Defining the relationship between ovarian hormones and migraine headache. Headache. 2005;45:1190-201.
  8. Glaser R., Dimitrakakis C., Trimble N., Martin V. Testosterone pellet implants and migraine headaches: a pilot study. Maturitas. 2012;71(4):385-8.
  9. Isselee H., De Laat A., De Mot B., Lysens R. Pressure-pain threshold variation in temporomandibular disorder myalgia over the course of the menstrual cycle. J. Orofac. Pain. 2002;16:105-17.
  10. Lora V.R., Canales Gde L., Gonçalves L.M., Meloto C.B, Barbosa C.M. Prevalence of temporomandibular disorders in postmenopausal women and relationship with pain and HRT. Braz. Oral. Res. 2016;30(1):e100.
  11. Данилов А.Б., Данилов Ал.Б. Управляй болью. Биопсихосоциальный подход. М.: АММ ПРЕСС, 2012. 137 с. [Danilov A.B., Danilov Al.B. Manage the pain. Biopsychosocial approach. М.: АММ PRESS, 2012. P.137.]
  12. Anderson J.K., Tuetken R., Hoffman V. A potential relationship between diffuse musculoskeletal pain and hypogonadism. BMJ Case Rep. 2010; 2010. pii: bcr08.2009.2152.
  13. Pamuk O.N., Cakir N. The variation in chronic widespread pain and other symptoms in fibromyalgia patients. The effects of menses and menopause. Clin. Exp. Rheumatol. 2005;23:778-82.
  14. White H.D., Brown L.A., Gyurik R.J., Manganiello P.D., Robinson T.D., Hallock L.S., Lewis L.D., Yeo K.T. Treatment of pain in fibromyalgia patientswith testosterone gel: Pharmacokinetics and clinical response. Int. Immunopharmacol. 2015;27(2):249-56.
  15. Li R.H., Gebbie A.E., Wong R.W., Ng E.H., Glasier A.F., Ho P.C. The use of sex hormones in women with rheumatological diseases. Hong Kong Med. J. 2011;17(6):487-91.
  16. Pikwer M., Giwercman A., Bergström U., Nilsson JA., Jacobsson L.T., Turesson C. Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case-control study. Ann. Rheum. Dis. 2014;73(3):573-9.
  17. Matheis A., Martens U., Kruse J., Enck P. Irritable bowel syndrome and chronic pelvic pain: a singular or two different clinical syndrome? World J. Gastroenterol. 2007;13:3446-55.
  18. Vercellini P., Somigliana E., Vigano P., Abbiati A., Barbara G., Fedele L. Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach. Gynecol. Endocrinol. 2009;25:149-58.
  19. Houghton L.A., Jackson N.A., Whorwell P.J., Morris J. Do Male Sex Hormones Protect From Irritable Bowel Syndrome? Am. J. Gastroenterol. 2000; 95(9):2296-3000.
  20. Tishova Y.A., Mskhalaya G.Z., Saad F., Kalinchenko S.Y. Effect of testosterone treatment on inflammatory markers in men with late-onsethypogonadism (LOH) and metabolic syndrome (MS). J. Men Health Gender. 2013;4(3):366.
  21. Курбатов Д.Г., Кузнецкий Ю.Я., Роживанов Р.В., Дубский С.А. Применение тестостерона в комбинированной терапии больных синдромом хронической тазовой боли и андрогенодефицитом. Вестник репродуктивного здоровья. 2008;3-4:39-44. [Kurbatov D.G., Kuznetzky Ju.Ya., Rozhivanov R.V., Dubsky S.A. Use of testosterone in combined therapy for chronic pelvic pain and androgen deficiency patients. Reproductive health bulletin. 2008;3-4:39-44.]
  22. Vodo S., Bechi N., Petroni A., Muscoli C., Aloisi A.M. Testosterone-Induced Effects on Lipids and Inflammation. Hindawi Publishing Corporation. Mediators of Inflammation. Volume 2013.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies