Influence of TGF-β1 expression on the development of tubulointerstitial fibrosis in patients with primary chronic glomerulonephritis

Objective: to study the role of transforming growth factor-B1 (TGF-β1) in the development of tubulointerstitial fibrosis (TIF) in patients with primary glomerulonephritis. Material and methods. The study included 75 patients (aged 18 to 80 years) with primary chronic glomerulonephritis in the acute phase, who underwent puncture nephrobiopsy if indicated. As a result of the immunohistochemical analysis of the biopsy, it was established: a weak degree of expression of TGF-β1 - in 15 biopsies, moderate - in 44, significant - in 15. Results. When studying the effect of TGF-β1 on the severity of TIF, a directly proportional correlation relationship was established (r - 0.37; p <0.05). Expressed expression of TGF-B1 was noted in the epithelium of the proximal tubule. This effect is probably due to the fact that in the presence of damage, these cells can have a paracrine effect on the surrounding tissues. Conclusion. TGF-B1 is involved in the development of irreversible changes in various parts of the nephron, which makes it possible to consider the studied marker as one of the potential prognostic criteria for the outcome of chronic kidney disease.

transforming growth factor-β1, tubulointerstitial fibrosis, primary chronic glomerulonephritis