Influence of TGF-β1 expression on the development of tubulointerstitial fibrosis in patients with primary chronic glomerulonephritis


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Abstract

Objective: to study the role of transforming growth factor-B1 (TGF-β1) in the development of tubulointerstitial fibrosis (TIF) in patients with primary glomerulonephritis. Material and methods. The study included 75 patients (aged 18 to 80 years) with primary chronic glomerulonephritis in the acute phase, who underwent puncture nephrobiopsy if indicated. As a result of the immunohistochemical analysis of the biopsy, it was established: a weak degree of expression of TGF-β1 - in 15 biopsies, moderate - in 44, significant - in 15. Results. When studying the effect of TGF-β1 on the severity of TIF, a directly proportional correlation relationship was established (r - 0.37; p <0.05). Expressed expression of TGF-B1 was noted in the epithelium of the proximal tubule. This effect is probably due to the fact that in the presence of damage, these cells can have a paracrine effect on the surrounding tissues. Conclusion. TGF-B1 is involved in the development of irreversible changes in various parts of the nephron, which makes it possible to consider the studied marker as one of the potential prognostic criteria for the outcome of chronic kidney disease.

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About the authors

Aytan V. Mukhtarova

Rostov State Medical University of the Ministry of Healthcare of Russia

Email: ayka.mukhtarova@gmail.com
the Head of the dialysis unit No. 2 ”LLC DC NEFROS-DON", post-graduate student of the Internal Medicine Department No. 2

Mikhail M. Batyushin

Rostov State Medical University of the Ministry of Healthcare of Russia

MD, PhD, DMedSci professor, professor of the internal medicine Department of No. 2, the Head of the nephrology Department

Elena A. Sinelnik

Regional Clinical Hospital No. 2, Rostov-on-Don

Email: ob2p@mail.ru
Candidate of Medical Sciences, the Head of the pathology Department

Natalia V. Antipova

Regional Clinical Hospital No. 2, Rostov-on-Don

Email: ob2p@mail.ru
the Head of the nephrology Department

Hani Z. Gadaborsheva

Rostov State Medical University of the Ministry of Healthcare of Russia

Candidate of Medical Sciences, Nephrologist

References

  1. Семешина О.В., Лучанинова В.Н., Маркелова Е.В. с соавт. Особенности экскреции цитокинов с мочой при хронической болезни почек у детей. Клиническая нефрология. 2017; 3: 46-53.
  2. Isaka Y. Targeting TGF-β signaling in kidney fibrosis. Int J. Mol Sci. 2018; 19(9): 2532. doi: 10.3390/ijms19092532.
  3. Finnson K.W., Almadani Y., Philip А. Non-canonical (non-SMAD2/3) TGF-B signaling in fibrosis: Mechanisms and targets. Semin Cell Dev Biol. 2020; 101: 115-22. doi: 10.1016/j.semcdb.2019.11.013.
  4. David C.J., Massague J. Contextual determinants of TGFβ action in development, immunity and cancer. Nat Rev Mol Cell Biol. 2018; 19(7): 419-35. doi: 10.1038/s41 580-018-0007-0.
  5. Москалев А.В., Рудой А.С., Апчел А.В. с соавт. Особенности биологии трансформирующего ростового фактора В. и иммунопатология. Вестник Российской военно-медицинской академии. 2016; 2: 206-216.
  6. Соколова А.В., Драгунов Д.О., Арутюнов Г.П. с соавт. Влияние избыточного потребления соли на изменение тубулоин-терстициальной ткани почек пациентов с гипертонической болезнью. Морфологическое исследование. Клиническая нефрология. 2017; 4: 42-50.
  7. Gewin L.S. Renal fibrosis: Primacy of the proximal tubule. Matrix Biol. 2018; 68-69: 248-62. doi: 10.1016/j.matbio.2018.02.006.
  8. Gu Y.Y., Dou J.Y., Huang X.R. et al. Transforming growth factor-B and long non-coding RNA in renal inflammation and fibrosis. Front Physiol. 2021; 12: 684236. doi: 10.3389/fphys.2021.684236.
  9. Gu Y.Y., Liu X.S., Huang X.R. et al. Diverse role of TGF-β in kidney disease. Front Cell Dev Biol. 2020; 8: 123. doi: 10.3389/ fcell.2020.00123.
  10. Kim K., Sheppard D., Chapman H. TGF-β1 signaling and tissue fibrosis. Cold Spring Harb Perspect Biol. 2018; 10(4): 1-34. doi: 10.1101/cshperspect.a022293.
  11. Harskamp L.R., Gansevoort R.T., Van Goor H., Meijer E. The epidermal growth factor receptor pathway in chronic kidney diseases. Nat Rev Nephrol. 2016; 12(8): 496-506. doi: 10.1038/nrneph.2016.91.
  12. Батюшин М.М., Броновицкая Н.А., Гасанов М.З., Сарвилина И.В. Протеомный спектр мочи при нефропатиях различного генеза. Клиническая нефрология. 2014; 1:50-54

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