Chronic obstructive pulmonary disease in combination with type 2 diabetes mellitus: features of the clinical picture


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Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (DM2) are known to be comorbid diseases united by common pathogenetic pathways, among which systemic inflammation plays an important role. The aim is to establish the features of the course of COPD in combination with type 2 diabetes according to the data of clinical and laboratory-instrumental examinations. Material and methods. We examined 42 patients with COPD, 25 patients with a combination of COPD and DM2, 17 patients with DM2. All patients underwent a clinical and laboratory examination (Complete blood count and biochemical analysis), echocardiography, spirometry with a bronchodilator test. Results. The group of patients with a combination of COPD and DM2 was characterized by high values of the body mass index, which is due to the contribution of the metabolic syndrome in this group. Such characteristics as the stage, clinical group, and phase of COPD in the groups with and without co-existing DM2 did not differ statistically significantly. The degree of respiratory failure was significantly higher in the group with a combination of COPD and DM2. In addition, the presence and severity of comorbidity of the cardiovascular system and the presence of cerebrovascular disease were significantly higher in the COPD group with co-existing DM2. The prevalence and degree of pulmonary hypertension in the groups with COPD did not differ. The results of laboratory tests, in general, are typical for these diseases. Conclusion. Thus, it is confirmed that the course of COPD is worsened in the presence of comorbid conditions, in particular DM2, which should be taken into account in the management of patients with comorbid pathology, as well as in the development of approaches to the early diagnosis and treatment of these conditions.

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作者简介

L. Sorokina

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia

Email: lada_sorokina@mail.ru
197022, St. Petersburg, Saint Petersburg, 6-8 L. Tolstogo Str

A. Pavlova

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia

Email: pavast02@gmail.com
197022, St. Petersburg, Saint Petersburg, 6-8 L. Tolstogo Str

V. Mineev

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia

Email: vnmineev@mail.ru
197022, St. Petersburg, Saint Petersburg, 6-8 L. Tolstogo Str

V. Trofimov

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia

Email: trofvi@mail.ru
197022, St. Petersburg, Saint Petersburg, 6-8 L. Tolstogo Str

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