Cytomegalovirus infection during pregnancy period

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Cytomegalovirus infection (CMV) during pregnancy can lead to fetus intrauterine infection arising with a high risk of congenital CMV developing, which is a leading cause of irreversible neurological deficit, hearing and vision loss. Methods of preventing antenatal infection, including the use of immunological and antiviral drugs, are remaining to be actual for discussion. The article presents cases of CMV infection during pregnancy and its implementation in newborn children (both according to literature data and based on our own clinical observations). Approaches to timely diagnostics and the possibilities of CMV infection therapy, which help minimize the social consequences of the disease, are introduced.

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作者简介

Valery Vasiliev

Children’s Scientific and Clinical Center of FMBA of Russia; I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: vcubed@ya.ru
ORCID iD: 0000-0002-7336-8805

MD, Dr. Sci. (Medicine), head of the Scientific and Research Department of congenital infectious diseases, professor of the Department of infectious diseases

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Ivan Markin

Children’s Scientific and Clinical Center of FMBA of Russia

Email: i.v.markin@mail.ru
ORCID iD: 0000-0001-9922-401X

MD, postgraduate student of the Scientific and Research Department of congenital infectious diseases

俄罗斯联邦, Saint Petersburg

Natalia Rogozina

Children’s Scientific and Clinical Center of FMBA of Russia

Email: lelekin96@mail.ru
ORCID iD: 0000-0003-0968-6291

MD, PhD (Medicine), senior researcher at the Scientific and Research Department of congenital infectious diseases

俄罗斯联邦, Saint Petersburg

Natalya Skripchenko

Children’s Scientific and Clinical Center of FMBA of Russia; Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of Russia

Email: snv@niidi.ru
ORCID iD: 0000-0001-8927-3176

MD, Dr. Sci. (Medicine), professor, deputy director for research, head of the Department of infectious diseases in pediatrics of the Faculty of postgraduate and continuing professional education

俄罗斯联邦, Saint Petersburg; Saint Petersburg

参考

  1. Pesch M.H., Saunders N.A., Abdelnabi S. Cytomegalovirus infection in pregnancy: Prevention, presentation, management and neonatal outcomes. J Midwifery Womens Health. 2021; 66(3): 397–402. https://doi.org/10.1111/jmwh.13228. PMID: 34031974.
  2. Choodinatha H.K., Jeon M.R., Choi B.Y. et al. Cytomegalovirus infection during pregnancy. Obstet Gynecol Sci. 2023. 66(6): 463–76. https://doi.org/10.5468/ogs.23117. PMID: 37537975. PMCID: PMC10663402.
  3. Передельский Е.В., Юркаев И.М., Мальцев О.В. с соавт. Клинический случай тяжелого течения острой сочетанной генерализованной герпетической инфекции (EBV и CMV). Лечение и профилактика. 2021; 11(2): 84–90. [Peredelskiy E.V., Yurkaev I.M., Maltsev O.V. et al. A clinical case of a severe course of acute combined generalized herpes infection (EBV and CMV). Lechenie i profilaktika = Treatment and Prevention. 2021; 11(2): 84–90 (In Russ.)]. EDN: VHKBYQ.
  4. Sartori P., Egloff C., Hcini N. et al. Primary, secondary, and tertiary prevention of congenital cytomegalovirus infection. Viruses. 2023; 15(4): 819. https://doi.org/10.3390/v15040819. PMID: 37112800. PMCID: PMC10146889.
  5. Нормальная беременность (клинические рекомендации). Акушерство и гинекология: новости, мнения, обучения. 2020; (4): 48–78. [Normal pregnancy (clinical recommendations). Akusherstvo i ginekologiya: novosti, mneniya, obucheniya = Obstetrics and Gynecology: News, Opinions, Training. 2020; (4): 48–78 (In Russ.)].
  6. Prince H.E., Lapé-Nixon M. Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clin Vaccine Immunol. 2014; 21(10): 1377–84. https://doi.org/10.1128/CVI.00487-14. PMID: 25165026. PMCID: PMC4266349.
  7. Kagan K.O., Enders M., Schampera M.S. et al. Prevention of maternal-fetal transmission of cytomegalovirus after primary maternal infection in the first trimester by biweekly hyperimmunoglobulin administration. Ultrasound Obstet Gynecol. 2019; 53(3): 383–89. https://doi.org/10.1002/uog.19164. PMID: 29947159.
  8. Seidel V., Hackelöer M., Rancourt R.C. et al. Fetal and maternal outcome after hyperimmunoglobulin administration for prevention of maternal-fetal transmission of cytomegalovirus during pregnancy: retrospective cohort analysis. Arch Gynecol Obstet. 2020; 302(6): 1353–59. https://doi.org/10.1007/s00404-020-05728-7. PMID: 32754858. PMCID: PMC7584525.
  9. Revello M.G., Lazzarotto T., Guerra B. et al. A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. N Engl J Med. 2014; 370(14): 1316–26. https://doi.org/10.1056/NEJMoa1310214. PMID: 24693891.
  10. Negishi H., Yamada H., Hirayama E. et al. Intraperitoneal administration of cytomegalovirus hyperimmunoglobulin to the cytomegalovirus-infected fetus. J Perinatol. 1998; 18(6 Pt 1): 466–69. PMID: 9848763.
  11. Sato A., Hirano H., Miura H. et al. Intrauterine therapy with cytomegalovirus hyperimmunoglobulin for a fetus congenitally infected with cytomegalovirus. J Obstet Gynaecol Res. 2007; 33(5): 718–21. https://doi.org/10.1111/j.1447-0756.2007.00637.x. PMID: 17845336.
  12. Horst B., Stackelberg Otto M.v., Schlößer R.L. et al. Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: A retrospective analysis. J Perinat Med. 2012; 40(4): 439–46. https://doi.org/10.1515/jpm-2011-0257. PMID: 22752777.
  13. D’Antonio F., Marinceu D., Prasad S., Khalil A. Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: Systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2023; 61(4): 436–44. https://doi.org/10.1002/uog.26136. PMID: 36484439.
  14. Shahar-Nissan K., Pardo J., Peled O. et al. Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: A randomised, double-blind, placebo-controlled trial. Lancet. 2020; 396(10253): 779–85. https://doi.org/10.1016/S0140-6736(20)31868-7. PMID: 32919517.
  15. Seidel V., Feiterna-Sperling C., Siedentopf J.P. et al. Intrauterine therapy of cytomegalovirus infection with valganciclovir: Review of the literature. Med Microbiol Immunol. 2017; 206(5): 347–54. https://doi.org/10.1007/s00430-017-0512-3. PMID: 28733760.
  16. Brady R.C., Schleiss M.R., Witte D.P. et al. Placental transfer of ganciclovir in a woman with acquired immunodeficiency syndrome and cytomegalovirus disease. Pediatr Infect Dis J. 2002; 21(8): 796–97. https://doi.org/10.1097/00006454-200208000-00023. PMID: 12233717.
  17. Bergin S., Ferguson W., Corcoran S. et al. Symptomatic primary Cytomegalovirus infection in a HIV-positive pregnant woman. Int J STD AIDS. 2014; 25(14): 1041–43. https://doi.org/10.1177/0956462414528314. PMID: 24648317.

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2. Fig. 1. Ultrasound examination of the brain of the child of the observed patient O. (2nd day of life)

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3. Fig. 2. Magnetic resonance imaging of the brain of the child of the observed patient O.

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