THE LEGACY OF FUNDAMENTAL SCIENCE IN THE NATIONAL MEDICAL RESEARCH CENTER FOR ONCOLOGY OF THE MINISTRY OF HEALTH OF RUSSIA

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Abstract

This article is devoted to the formation of a scientific approach to managing the state of the body during the development of the tumor process. This approach is based on the discovery of the pattern of development of different general non-specific adaptational reactions depending on the acting factor intensity, which determined the prospects for increasing antitumor resistance of the organism. Changes in the state of the central nervous system, endocrine and immune systems, which distinguish antistressor adaptational reactions from each other and from the G. Selye’ stress were revealed. Signal hematological criteria of four main archetypes of reactions – training, calm and elevated activation, as well as stress – have been established. When testing factors of different nature in a wide range of intensity, a new previously unknown system of periodic repetition of the tetrad of reactions at different levels of the body’s reactivity was revealed. These ideas significantly expanded the possibilities of managing the adaptive state of the body in oncopathology, as well as in other serious diseases and aging. A new therapeutic direction was founded – the activation therapy – which uses effective regimes of treating influence on the body of factors of various nature. The possibilities of activation electromagnetic therapy as an accompanying treatment in adjuvant chemotherapy and radiation therapy of tumors of various localization were shown. The influence of neurogenic pain on the malignant process and electrophysiological processes in neurons has been studied. A new paradigm of psychosomatic medicine based on the relation of the physical and psychological state with the archetype of the integral adaptive response of the organism with multilevel mechanisms of formation (from subcellular to systemic) was presented.

About the authors

O. I Kit

National Medical Research Center for Oncology of the Ministry of Health of Russia

Rostov-on-Don, Russian Federation

A. I Shikhlyarova

National Medical Research Center for Oncology of the Ministry of Health of Russia

Email: shikhliarova.a@mail.ru
Rostov-on-Don, Russian Federation

E. M Franzyants

National Medical Research Center for Oncology of the Ministry of Health of Russia

Rostov-on-Don, Russian Federation

I. V Kaplieva

National Medical Research Center for Oncology of the Ministry of Health of Russia

Rostov-on-Don, Russian Federation

G. V Zhukova

National Medical Research Center for Oncology of the Ministry of Health of Russia

Rostov-on-Don, Russian Federation

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