Inclusion Complex of Nitrate γ-Cyclodextrine with Conjugate of Tetrahydrocarbasol and Aminoadamantane

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Abstract

The possibility of obtaining the inclusion complex of γ-cyclodextrin nitrate with tetrahydrocarbazole and aminoadamantane conjugate, a promising drug for the treatment of neurodegenerative diseases, was investigated and proved using XRD, DSC, HPLC and NMR. It was found that the obtained complex, unlike the active substance itself, is soluble in water, and its cellular toxicity does not exceed that of the active substance, which contributes to the increase of its bioavailability and provides the possibility of conducting the necessary biological studies. It was found that the formed inclusion complex preserves the medicinal properties of the active substance, exhibiting mitoprotective and microtubule-stabilizing activities, and also possesses a pronounced antioxidant activity, effectively inhibiting spontaneous lipid peroxidation in rat brain homogenate.

About the authors

Yu. M. Mikhailov

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru

Academician of the RAS

Russian Federation, 142432 Chernogolovka

S. O. Bachurin

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru

Academician of the RAS

Russian Federation, 142432 Chernogolovka

A. V. Darovskikh

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Author for correspondence.
Email: avd@icp.ac.ru
Russian Federation, 142432 Chernogolovka

I. M. Veselov

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Russian Federation, 142432 Chernogolovka

P. N. Shevtsov

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Russian Federation, 142432 Chernogolovka

A. V. Maltsev

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Russian Federation, 142432 Chernogolovka

E. F. Shevtsova

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Russian Federation, 142432 Chernogolovka

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