STUDYING ANTITUMOR ACTIVITY  IN VITRO  IODO-δ-LACTONES 5 Z ,9 Z -DIENOIC ACID

E. Kh. Makarova; Макарова Э. Х.; I. V. Ishbulatov; Ишбулатов И. В.; А. А. Makarov; Макаров А. А.; L. U. Dzhemileva; Джемилева Л. У.; U. M. Dzhemilev; Джемилев У. М.; V. A. D’yakonov; Дьяконов В. А.

doi:10.31857/S2686953523600277

STUDYING ANTITUMOR ACTIVITY IN VITRO IODO-δ-LACTONES 5Z,9Z-DIENOIC ACID

Autores: Makarova E.K.¹, Ishbulatov I.V.¹, Makarov А.А.¹, Dzhemileva L.U.², Dzhemilev U.M.², D’yakonov V.A.²
Afiliações:
1. Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences
2. N.D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences
Edição: Volume 513, Nº 1 (2023)
Páginas: 54-61
Seção: CHEMISTRY
URL: https://journals.eco-vector.com/2686-9535/article/view/651931
DOI: https://doi.org/10.31857/S2686953523600277
EDN: https://elibrary.ru/UWUBSS
ID: 651931

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Resumo

A previously undescribed phenyl-substituted iodo-δ-lactone of 11‑phenylundeca-5Z,9Z-dienoic acid was synthesized using the Ti-catalyzed intermolecular cross-cyclomagnesiation of an aromatic 1,2-diene with an O‑containing allene at the key stage in a 94% yield. The in vitro cytotoxic activity of the obtained alkyl- and phenyl-substituted iodo-δ-lactones 5Z,9Z-dienoic acids was studied in relation to the cell lines Jurkat, K562, U937, HL60, Hek293, and the effect on the cell cycle and the ability to induce apoptosis with using flow cytometry.

Palavras-chave

cross-cyclomagnesiation, 1,2-dienes, iodo-δ-lactones, Cp₂TiCl₂, cytotoxic activity, apoptosis, Jurkat, K562, U937, HL60, Hek293

Bibliografia

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