HIV infection, secondary conditions and comorbidities. Part 2. Concomitant diseases

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  • Authors: Rassokhin V.V.1,2,3, Leonova O.N.1,4, Boeva E.V.1,2, Stepanova E.V.1,4, Belyakov N.A.1,2,3, DiClemente R.5
  • Affiliations:
    1. Pavlov First Saint Petersburg State Medical University
    2. Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology
    3. Institute of Experimental Medicine
    4. Saint Petersburg Centre for Prevention and Control of AIDS and Infectious Diseases
    5. Department of Epidemiology College of Global Public Health New York University
  • Issue: Vol 19, No 1 (2019)
  • Pages: 5-16
  • Section: Review
  • URL: https://journals.eco-vector.com/MAJ/article/view/15184
  • DOI: https://doi.org/10.17816/MAJ1915-16
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Abstract


Comorbid conditions are typical for many chronic pathological processes, especially at a mature and old age. For several reasons, a special place in the formation of these conditions takes HIV infection in combination with non-communicable diseases. The general characteristics of the secondary athologies, which remain one of the leading causes of severe complications and mortality, are presented. Particular attention is focused on possible concomitant somatic pathology, which may affect the quality of life and the prognosis. Among pathological precosses are lesions of the gastrointestinal and urinary tracts, cardiovascular diseases and malignant neoplasms. A method for the integrated assessment of the severity of a patient’s condition with a combination of comorbidity and HIV infection is presented. This method allows to improve the prediction of the course and outcome of the main and associated diseases, as well as to influence the nature of the diagnostic and therapeutic processes.


Vadim V. Rassokhin

Pavlov First Saint Petersburg State Medical University; Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology; Institute of Experimental Medicine

Email: ras-doc@mail.ru

Russian Federation, Saint Petersburg

MD, PhD, Professor of the Department of Socially Significant Infections; Leading Research Associate; Head of the Laboratory of Chronic Viral Infections, Department of Ecological Physiology

Olga N. Leonova

Pavlov First Saint Petersburg State Medical University; Saint Petersburg Centre for Prevention and Control of AIDS and Infectious Diseases

Email: ras-doc@mail.ru

Russian Federation, Saint Petersburg

MD, PhD, Associate Professor of the Department of Socially Significant Infections; Head of the Saint Petersburg Center for Prevention and Control of AIDS and Infectious Diseases

Ekaterina V. Boeva

Pavlov First Saint Petersburg State Medical University; Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology

Author for correspondence.
Email: kathrine.boeva@gmail.com

Russian Federation, Saint Petersburg

Assistant of the Department of Socially Significant Infections; Head of the Department of Chronic Viral Infection 

Elena V. Stepanova

Pavlov First Saint Petersburg State Medical University; Saint Petersburg Centre for Prevention and Control of AIDS and Infectious Diseases

Email: kathrine.boeva@gmail.com

Russian Federation, Saint Petersburg

Professor, Department of Socially Significant Infections; MD, PhD, Deputy Chief Medical Officer

Nikolay A. Belyakov

Pavlov First Saint Petersburg State Medical University; Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology; Institute of Experimental Medicine

Email: kathrine.boeva@gmail.com

Russian Federation, Saint Petersburg

MD, PhD, Professor, Academician of the Russian Academy of Sciences, Head of the Department of Socially Significant Infections; Head of the North-Western District AIDS Prevention and Control Center; Chief Research Worker

Ralph J. DiClemente

Department of Epidemiology College of Global Public Health New York University

Email: kathrine.boeva@gmail.com

United States, New York

MD, PhD, Professor, Chair of the Department of Social and Behavioral Sciences; Professor, Department of Epidemiology

  1. Belyakov NA, Trofimova TN, Rassokhin VV. Diagnostics and mechanisms of the damage of the central nervous system in HIV-infection. Med Acad J. 2012;12(2):56-67. (In Russ.). https://doi.org/10.17816/MAJ12256-67.
  2. Trofimova TN, Belyakov NA, Rassokhin VV. Radiology and HIV infection. Saint Petersburg: Baltic Medical Educational Center; 2017. 352 p. (In Russ.)
  3. Gajsina AF, Magonov EP, Gromova EA, et al. Pathological Mechanisms of Hiv-Associated Neurocognitive Frustration. Diagnostic radiology and radiotherapy. 2016;(2):6-21. https://doi.org/10.22328/2079-5343-2016-2-6-21.
  4. Belyakov NA. Golovnoy mozg kak mishen’ dlya VICh. Saint Petersburg: Baltic Medical Educational Center; 2011. 48 p. (In Russ.)
  5. Khalezova NB, Neznanov NG, Belyakov NA. HIV infection and mental disorders: modern view of the problem. Med Acad J. 2014;14(3):14-32. (In Russ.). https://doi.org/10.17816/MAJ14314-32.
  6. Belyakov NA. HIV infection – Medicine. Saint Petersburg; 2011. 656 p. (In Russ.)
  7. HIV 2015/16. Ed. by C. Hoffman, J.K. Rockstroh. Hamburg: Medizin Fokus Verlag; 2015.
  8. Taylor LE, Swan T, Mayer KH. HIV coinfection with hepatitis C virus: evolving epidemiology and treatment paradigms. Clin Infect Dis. 2012;55 Suppl 1:S33-42. https://doi.org/10.1093/cid/cis367.
  9. Belyakov NA, Rassokhin VV. Comorbid conditions in HIV infection. Part 3. Diseases of organs and systems. Saint Petersburg: Baltic Medical Educational Center; 2019. 220 p. (In Russ.)
  10. Belyakov NA, Rassokhin VV, Trofimova TN, et al. Advanced and comorbid HIV cases in Russia. HIV Infection and Immunosuppressive Disorder. 2016;8(3):9-25. (In Russ.). https://doi.org/10.22328/2077-9828-2016-8-3-9-25.
  11. Rassokhin VV, Belyakov NA, Rozental VV, et al. Secondary and somatic diseases in HIV patients. HIV Infection and Immunosuppressive Disorder. 2014;6(1):7-18. (In Russ.). https://doi.org/10.22328/2077-9828-2014-6-1-7-18.
  12. Dandachi D, Hassan M, Kaseb A, et al. Hepatitis C virus-associated hepatocellular carcinoma as a second primary malignancy: exposing an overlooked presentation of liver cancer. J Hepatocell Carcinoma. 2018;5:81-86. https://doi.org/10.2147/JHC.S164568.
  13. Belyakov NA, Rassokhin VV. Comorbid conditions in HIV infection. Part 1 Basis of the problem. Saint Petersburg: Baltic Medical Educational Center; 2018. 184 p. (In Russ.)
  14. Rihana N, Nanjappa S, Sullivan C, et al. Malignancy trends in HIV-infected patients over the past 10 years in a single-center retrospective observational study in the United States. Cancer Control. 2018;25(1):1073274818797955. https://doi.org/10.1177/1073274818797955.
  15. Nekrasova AV, Leonova ON, Stepanova YV, Rassokhin VV. Characteristics of tumor development in HIV patients in Saint Petersburg. HIV Infection and Immunosuppressive Disorders. 2016;8(1):31-41. (In Russ.). https://doi.org/10.22328/2077-9828-2016-8-1-31-41.
  16. Goehringer F, Bonnet F, Salmon D, et al. Causes of death in HIV-infected individuals with immunovirologic success in a national prospective survey. AIDS Res Hum Retroviruses. 2017;33(2):187-193. https://doi.org/10.1089/AID.2016.0222.
  17. Duffau P, Ozanne A, Bonnet F, et al. Multimorbidity, age-related comorbidities and mortality: association of activation, senescence and inflammation markers in HIV adults. AIDS. 2018;32(12):1651-1660. https://doi.org/10.1097/QAD.0000000000001875.
  18. Belyakov NA, Rassokhin VV. Comorbid conditions in HIV infection. Part 2. Secondary and concomitant infections. Saint Petersburg: Baltic Medical Educational Center; 2019. 252 p. (In Russ.)
  19. Borodulina EA, Tsygankov IL, Borodulin BE, et al. Drug addiction, HIV infection, tuberculosis. Features of multicomirbidity in modern conditions. Bulletin of contemporary clinical medicine. 2014;7(4):18-22.
  20. Onischenko GG. HIV infection: a challenge to humanity. HIV Infection and Immunosuppressive Disorders. 2009;1(1):5-9. (In Russ.)
  21. Rassokhin VV, Buzunova SA, Vrackikh TV, et al. The problem of senescence and debilitation of HIV patients. HIV Infection and Immunosuppressive Disorders. 2015;7(1):7-15. (In Russ.). https://doi.org/10.22328/2077-9828-2015-7-1-7-15.
  22. Bobkova MR. Lekarstvennaya ustoychivost’ VICh. Moscow: Chelovek; 2014. 288 p. (In Russ.)
  23. Bulekov IS, Samarina AV. Specificities of care provision to HIV infected pregnant drug-abusing women. HIV Infection and Immunosuppressive Disorders. 2012;4(1):31-41. (In Russ.)
  24. VICh-infektsiya i tsentral’naya nervnaya sistema. Meditsinskiy tematicheskiy arkhiv. Ed. by N.A. Belyakov, T.N. Trofimova, V.V. Rassokhin. Saint Petersburg: Baltic Medical Educational Center; 2013. 122 p. (In Russ.)
  25. Tursunov RA. Coinfection with HIV and parenteral viral hepatitis in drug addicts. Vestnik Avitsenny. 2012;(2):182-189. (In Russ.)
  26. Patent RUS No. 2454941/10.07.2012. Simovanyan EM, Denisenko VB. Sposob prognozirovaniya varianta techeniya VICh-infektsii u detey. (In Russ.)
  27. Needham DM, Scales DC, Laupacis A, Pronovost PJ. A systematic review of the Charlson comorbidity index using Canadian administrative databases: a perspective on risk adjustment in critical care research. J Crit Care. 2005;20(1):12-19.
  28. Belyakov NA, Rassokhin VV, Leonova ON, et al. An Integral Estimate of the Severity of Hiv Infection in Patients with Comorbidities. HIV Infection and Immunosuppressive Disorders. 2017;9(3):47-53. https://doi.org/10.22328/2077-9828-2017-9-3-47-53.

Supplementary files

Supplementary Files Action
1. Fig. 1. Causes of disabilities among HIV-infected patients in St. Petersburg (2008–2015) View (106KB) Indexing metadata

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Copyright (c) 2019 Rassokhin V.V., Leonova O.N., Boeva E.V., Stepanova E.V., Belyakov N.A., DiClemente R.

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