Metastatic breast cancer to kidney tumor: case report

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Abstract

Aim of the study is to demonstrate a unique case report: synchronous malignant tumors of the breast and kidney with tumor to tumor metastasis.

Materials and methods. The analysis of medical history and the pathology study of surgical material using histological and immunohistochemical methods was carried out.

Results. Clinical observation of metastasis of triple-negative breast cancer in a synchronous renal cell carcinoma of the kidney in a 59-year-old woman has been described. Tumor to tumor metastases are diagnosed by a remote kidney with a neoplasm, hematuria, anemia, and thrombocytopenic syndrome manifested in the clinic.

Conclusions. Lifetime diagnosis of primary multiple tumors and metastatic lesions, including tumor to tumor metastasis, is quite difficult and requires careful clinical and pathology analysis to develop adequate tactics of surgical and conservative treatment.

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About the authors

Elena V. Ponomaryeva

City Clinical Oncology Center

Author for correspondence.
Email: damian85@mail.ru

MD, Chief of Pathology Department

Russian Federation, Saint Petersburg

Oleg G. Polushin

City Clinical Oncology Center

Email: damian85@mail.ru
ORCID iD: 0000-0003-0366-3662

MD, PhD, Pathology Department

Russian Federation, Saint Petersburg

Demyan P. Kovtun

City Clinical Oncology Center

Email: damian85@mail.ru
ORCID iD: 0000-0002-5526-1385

MD, Pathology Department

Russian Federation, Saint Petersburg

Aleksandr P. Karlov

City Clinical Oncology Center

Email: damian85@mail.ru

MD, 5th Oncourology Department

Russian Federation, Saint Petersburg

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Supplementary files

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2. Fig. 1. Metastasis of breast cancer (arrows) in renal clear cell carcinoma (H&E staining, original magnification: ×200)

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3. Fig. 2. Positive membrane reaction to CD10 in a kidney tumor: asterisks indicate uncolored chromogen clusters of metastatic elements (Immunohistochemistry, original magnification: ×400)

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4. Fig. 3. Positive reaction to cytokeratin 7 in a cancer embolus (Э) in a kidney tumor (Immunohistochemistry, original magnification: ×400)

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5. Fig. 4. Breast tumor: High-grade carcinoma of non-specific type (H&E staining, original magnification: ×200)

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Copyright (c) 2019 Ponomaryeva E.V., Polushin O.G., Kovtun D.P., Karlov A.P.

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