Email this article CYTOKINES AND BRAIN-DERIVED NEUROTROPHIC FACTOR IN CONTEXT OF COGNITIVE IMPAIRMENT IN THE ELDERLY
- Authors: Filippova Y.Y.1, Kholodilina ME1, Burmistrova AL1
-
Affiliations:
- Chelyabinsk State University
- Issue: Vol 19, No 1S (2019)
- Pages: 18-19
- Section: Articles
- Published: 15.12.2019
- URL: https://journals.eco-vector.com/MAJ/article/view/19301
- ID: 19301
Cite item
Open Access
Access granted
Abstract
The aim is to assess the levels of certain cytokines IL-6, TNF-α, IL-1β и IL-10, and BDNF in the blood plasma of the elderly, depending on degree of cognitive impairment. 65 elderly with (vascular dementia) or without cognitive impairment were enrolled in the study. The level of cytokines and BDNF were measured in plasma by ELISA. It was found that, regardless of the degree of cognitive impairment, the condition of systemic chronic low-grade inflammation is characteristic of the elderly. Against this background, plasma levels of BDNF were increased in elderly with vascular dementia, reaching statistical significance compared with healthy individuals. Such changes in the level of BDNF may reflect a compensatory repair mechanism in neurodegeneration or be associated with a defective axonal transport or utilization of BDNF in the central nervous system paralleled by increased serum concentrations.
Keywords
Full Text
About the authors
Yu Yu Filippova
Chelyabinsk State University
M E Kholodilina
Chelyabinsk State University
A L Burmistrova
Chelyabinsk State University
References
- Archer T. BDNF integrity in ageing and stress. MOJ Gerontol. Ger. 2017;1(6):155-158.
- Calabrese F, Rossetti AC, Racagni G, et al. Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity. Front. Cell Neurosci. 2014;22:430.
- Weinstein G, Beiser AS, Choi SH, et al. Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol. 2014;71(1):55-61.
- Angelucci F, Spalletta G, di Iulio F. Alzheimer’s diseases and mild cognitive impairment patient are characterized by increased BDNF serum levels. Curr. Alzheimer Res. 2010;7(1):15-20.
- Galic MA, Riazi K, Pittman QJ. Cytokines and brain excitability. Front. Neuroendocrinol. 2012;33:116-125.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).