EXPERIMENTAL MODEL OF CFS: COGNITIVE, PHYSICAL AND METABOLIC CHARACTERISTICS OF PATHOLOGY DEVELOPMENT

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

In the present study, an analysis of cognitive, behavioral, and metabolic changes during the dynamics of the development of pathology was conducted under an experimental model of chronic fatigue syndrome (CFS). A decrease in physical and research activity of experimental animals indicated the development of fatigue and a depressed emotional state. An increase in the concentration of lactate was also showed, that may indicate a violation of the energy metabolism.

Full Text

Restricted Access

About the authors

T A Filatenkova

Institute of Experimental Medicine, Saint Petersburg

S N Shanin

Institute of Experimental Medicine, Saint Petersburg

E E Fomicheva

Institute of Experimental Medicine, Saint Petersburg

E A Korneva

Institute of Experimental Medicine, Saint Petersburg; Saint Petersburg State University, Saint Petersburg

N B Serebryanaya

Institute of Experimental Medicine, Saint Petersburg; Saint Petersburg State University, Saint Petersburg; North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg

References

  1. Artsimovich NG, Galushina TS. Chronic fatigue syndrome. Moscow: New World; 2002. 350 p.
  2. James N. A Cronic Fatique Syndrome severity score based on case design criteria. Am J Transl Res. 2013;5(1):53-68.
  3. Amoak S. Investigating unexplained CFS. BMC Family Practice. 2016;17:81.
  4. Katafuchi T, Kondo T, Yasaka T, et al. Prolonged effects of polyriboinosinic: Induced by fatigue. Neuroscience. 2003;120(3):837-45.
  5. Fomicheva EE, Rybakina EG, Filatenkova TA. Activity of the hypothalamic-pituitary-adrenocortical system in the induction of chronic fatigue syndrome in the experiment. Russian Fiziol. Journal im. I.M. Se¬chenov. 2009;95(1):11-18.
  6. George A. Brooks What is glycolysis? Journal of Applied Physiology. 2010;108(6):1450-1451.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Filatenkova T.A., Shanin S.N., Fomicheva E.E., Korneva E.A., Serebryanaya N.B.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.